Indications, technique, and outcome of therapeutic apheresis in European pediatric nephrology units

Paglialonga, Fabio; Schmitt, Claus Peter; Shroff, Rukshana; Vondrák, Karel; Aufricht, Christoph; Watson, Alan R.; Ariceta, Gema; Fischbach, Michael; Klaus, Günter; Hölttä, Tuula; Bakkaloğlu, Sevcan A.; Zurowska, Aleksandra; Jankauskienė, Augustina; Walle, Johan Vande; Betti, Silvia; Wright, Elizabeth C.; Connell, Roy; Edefonti, Alberto

doi:10.1007/s00467-014-2907-3

Cited by 42 publications

(58 citation statements)

References 22 publications

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“…In our study, adverse event rate of 7.7% was comparable to that observed by Paglialonga et al using similar apheresis technique, but less than what they observed with membrane filtration . The adverse event rate in pediatric patients undergoing TPE in the literature ranges from 13.8% to 55% , which is much higher than in our study.…”

Section: Discussionsupporting

confidence: 82%

Efficacy and safety of therapeutic plasma exchange by using apheresis devices in pediatric atypical hemolytic uremic syndrome patients

Hans

Sharma

Marwaha

et al. 2015

J of Clinical Apheresis

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Section: Discussionsupporting

confidence: 82%

Efficacy and safety of therapeutic plasma exchange by using apheresis devices in pediatric atypical hemolytic uremic syndrome patients

Hans

Sharma

Marwaha

et al. 2015

J of Clinical Apheresis

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“…Therefore indications and possible complications are based on adult studies. However, it is a highly specialized procedure and should be performed by experienced staff in a specialized center to minimize risk of complications …”

Section: Discussionmentioning

confidence: 99%

Therapeutic plasma exchange in pediatric intensive care: Indications, results and complications

et al. 2020

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Therapeutic plasma exchange (TPE) is an effective treatment method in selective indications. Secondary to access and technical features, it is more difficult to apply in pediatric population than adults. The aim of this study is investigate safety, clinical indications, and results of this method in critically ill pediatric patients who need TPE treatment. All of the TPE procedures performed in a pediatric intensive care unit providing tertiary care during 4 years (2015–2019) were evaluated retrospectively. TPE procedures (635) were performed for 135 patients. Median age was 34 months (10‐108). Ninety‐seven patients had mechanical ventilation support. Sepsis with multiple organ failure was the most frequent indication and accounted for 44.4% (n = 60) of the indications followed by hematological and neurological diseases (19.2% and 9.6% respectively). TPE was performed alone in 469 cases (73.9%), in combination with continuous renal replacement therapy in 154 cases (24.2%), and additional to extracorporeal membrane oxygenation in 12 cases (1.9%). Hematological disease and sepsis subgroups had the highest intubation rate, mechanical ventilation period, PRISM score, organ failure count, and mortality. Fresh frozen plasma (FFP) was the most frequently used replacement fluid in 90.4% of the procedures. The most frequent anticoagulant used in TPE was acid citrate dextrose solution (79.3%). Procedural complications were detected in 104 cases (16.3%) and occurred during TPE sessions. Overall survival rate was 78.5%. We found that the non‐survivor group had significantly higher rates of organ failures (P = 0.0001), higher PRISM scores on admission (P = 0.0001), and higher rates of invasive ventilation support needed (P = 0.012). TPE is a treatment method which can be safely provided in healthcare facilities with necessary medical and technical requirements. Although it is riskier to provide such treatment to critically ill children, complications can be minimized in experienced healthcare facilities. Overall results are good and can vary depending on indication.

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“…8 Avrupa pediatrik nefroloji ünitelerinde renal nedenler dışında en sık terapötik plazmaferez endikasyonu nörolojik hastalıklardan GBS olarak bildirilmiştir. 9 Bizim hastalarımıza terapötik plazmaferez en sık GBS(%46,3) nedeniyle yapılmış olup literatür ile uyumludur. Hastaların %63,15'i(12/19 hasta) hızlı ilerleyen, mekanik ventilasyon gerektiren GBS olup bu 12 hasta plazmaferez tedavisi sonrası ekstübe edilerek servise devir edilmiştir.…”

Section: Discussionunclassified

Assessment of neurologic patients who treated therapeutic plasmapheresis at pediatric intensive care unit: 10 years experience

Tolunay¹,

Yildizdaş²,

İncecik³

et al. 2015

Turk J Ped Em Int Care Med

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Indications, technique, and outcome of therapeutic apheresis in European pediatric nephrology units

Abstract: PE, IA, and DFPP are safe apheresis methods in children. Efficacy is high in pediatric patients with recurrent focal segmental glomerulosclerosis (FSGS), atypical hemolytic uremic syndrome (HUS), human leukocyte antigen (HLA) sensitization, and neurological autoimmune diseases.

Cited by 42 publications

References 22 publications

Efficacy and safety of therapeutic plasma exchange by using apheresis devices in pediatric atypical hemolytic uremic syndrome patients

Efficacy and safety of therapeutic plasma exchange by using apheresis devices in pediatric atypical hemolytic uremic syndrome patients

Therapeutic plasma exchange in pediatric intensive care: Indications, results and complications

Assessment of neurologic patients who treated therapeutic plasmapheresis at pediatric intensive care unit: 10 years experience

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