Indications for the presence of antibodies cross-reactive with HTLV-I/II, but not HIV, in patients with myelodysplastic syndrome

Möstl, Michaela; Mucke, Hermann Am; Schinkinger, Manfred; Haushofer, Alexander; Krieger, O.; Lutz, D.

doi:10.1016/0090-1229(92)90251-i

Cited by 1 publication

(1 citation statement)

References 31 publications

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“…Venables and Brookes (191) and Talal et al (181) pointed out that care must be taken to distinguish antibodies to autoantigens from those that are specific for endogenous retroviruses. For example, Möstl et al (127) reported that sera from patients with a myelodysplastic syndrome cross-reacted with HTLV-1 and HTLV-2, although there was no evidence to suggest that such patients had ever been infected by either of these viruses. One approach used to resolve these problems was to directly isolate and characterize putative antiviral antibodies or their corresponding antigens, as shown, for example, by Derks et al (42) and Hehlmann and his associates (68).…”

Section: Vol 9 1996 Human Endogenous Retroviruses 93mentioning

confidence: 99%

Human endogenous retroviruses: nature, occurrence, and clinical implications in human disease

Urnovitz¹,

Murphy²

1996

Clin Microbiol Rev

175

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Retroviral diagnostics have become standard in human laboratory medicine. While current emphasis is placed on the human exogenous viruses (human immunodeficiency virus and human T-cell leukemia virus), evidence implicating human endogenous retroviruses (HERVs) in various human disease entities continues to mount. Literature on the occurrence of HERVs in human tissues and cells was analyzed. Substantial evidence documents that retrovirus particles were clearly demonstrable in various tissues and cells in both health and disease and were abundant in the placenta and that their occurrence could be implicated in some of the reproductive diseases. The characteristics of HERVs are summarized, mechanisms of replication and regulation are outlined, and the consistent hormonal responsiveness of HERVs is noted. Clear evidence implicating HERV gene products as participants in glomerulonephritis in some cases of systemic lupus erythematosus is adduced. Data implicating HERVs as etiologic factors in reproductive diseases, in some of the autoimmune diseases, in some forms of rheumatoid arthritis and connective tissue disease, in psoriasis, and in some of the inflammatory neurologic diseases are reviewed. The current major needs are to improve methods for HERV detection, to identify the most appropriate HERV prototypes, and to develop diagnostic reagents so that the putative biologic and pathologic roles of HERVs can be better evaluated.

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Section: Vol 9 1996 Human Endogenous Retroviruses 93mentioning

confidence: 99%