Indications for keratoplasty in management of corneal ectasia

Choi, Jamie H; Jeng, Bennie H.

doi:10.1097/icu.0000000000000862

Cited by 3 publications

(2 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Keratoconus (16) can be effectively treated with keratoplasty. Keratoconus at the edema stage is not a contraindication for keratoplasty, given the development and maturation of the process.…”

Section: Discussionmentioning

confidence: 99%

Comparison of keratoplasty outcomes at the scar versus edema stages of keratoconus

Chen,

You,

Wang

et al. 2024

ABO

View full text Add to dashboard Cite

To assess the outcomes of deep anterior lamellar keratoplasty or penetrating keratoplasty at the scar and the edema stages. Methods: Forty-five patients (45 eyes) with keratoconus scar stage (scar group, n=26; penetrating keratoplasty a subgroup, n=7; deep anterior lamellar keratoplasty b subgroup, n=19) and keratoconus edema stage (edema group, n=19; penetrating keratoplasty c subgroup, n=12; deep anterior lamellar keratoplasty d group, n=7) who received penetrating keratoplasty or deep anterior lamellar keratoplasty from 2000 to 2022 were retrospectively studied. At 1, 6, and 12 months after surgery, the best-corrected visual acuity, astigmatism, spherical equivalent, corneal endothelial cell density, and complications were analyzed. Results: The best-corrected visual acuity and average corneal endothelial cell loss rate were not significantly different between the scar and edema groups (p>0.05). At 6 and 12 months after surgery, the astigmatism and spherical equivalent in the scar group were significantly lower than those in the edema group (p<0.05). The spherical equivalent of the deep anterior lamellar keratoplasty b subgroup was lower than that of the penetrating keratoplasty a subgroup in the scar group 6 months after surgery (p<0.05). In the edema group, there was no significant difference in spherical equivalent between subgroups (p>0.05). There were no significant differences in best-corrected visual acuity and astigmatism between subgroups within the two groups (p>0.05). In comparison to the scar group, the edema group experienced more complications. According to a survival analysis, there was no statistically significant difference between the scar group and the edema group regarding the progression of vision. Conclusions: In terms of the outcomes and prognosis for vision after keratoplasty with edema stage and scar stage, deep anterior lamellar keratoplasty may be as effective as penetrating keratoplasty.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of keratoplasty outcomes at the scar versus edema stages of keratoconus

Chen,

You,

Wang

et al. 2024

ABO

View full text Add to dashboard Cite

show abstract

“…Individuals with a higher LOX expression in the ectatic area, an endogenous collagen crosslinking agent, have shown good CXL outcomes. A decrease in ocular surface inflammation post-CXL has been observed [40 ▪▪ ,51–53].…”

Section: Treatmentmentioning

confidence: 92%

Ocular surface inflammation and ectatic corneal disorders

Erdinest

Wajnsztajn

London

et al. 2023

Current Opinion in Allergy &Amp; Clinical Immunology

View full text Add to dashboard Cite

Purpose of review Inflammatory mediators are a focus of recent corneal ectasia (CE) research and are a profound, modifiable contributor to CE in general and keratoconus (KC) in particular, opening a path to explore new methods of control. As advanced imaging technology and expanded population screening allow for earlier detection, the possibility of early intervention can profoundly change the prognosis of CE. Recent findings Significant increases in the inflammatory mediators and immune components have been observed in the cornea, tear fluid, and blood of ectasia patients, while inflammation dampeners such as vitamin D and their receptors are reduced. Atopy and allergy have a strong association with KC, known to increase itch factors and stimulate eye rubbing, a risk factor in ectasia pathogenesis. Management of atopy or allergic conditions and topical anti-inflammatories has helped stabilize CE disease. Summary Strategies such as monitoring inflammatory factors and using immune or inflammatory modulators, including managing subclinical inflammation, may be clinically beneficial in stabilizing the disease and improving outcomes. The detected factors are biomarkers, but as yet unproven to be sensitive or specific enough to be considered biomarkers for early detection of CE. The establishment of such biomarkers could improve the therapeutic outcome.

show abstract

Bioprinted Membranes for Corneal Tissue Engineering: A Review

et al. 2022

View full text Add to dashboard Cite

Corneal transplantation is considered a convenient strategy for various types of corneal disease needs. Even though it has been applied as a suitable solution for most corneal disorders, patients still face several issues due to a lack of healthy donor corneas, and rejection is another unknown risk of corneal transplant tissue. Corneal tissue engineering (CTE) has gained significant consideration as an efficient approach to developing tissue-engineered scaffolds for corneal healing and regeneration. Several approaches are tested to develop a substrate with equal transmittance and mechanical properties to improve the regeneration of cornea tissue. In this regard, bioprinted scaffolds have recently received sufficient attention in simulating corneal structure, owing to their spectacular spatial control which produces a three-cell-loaded-dimensional corneal structure. In this review, the anatomy and function of different layers of corneal tissue are highlighted, and then the potential of the 3D bioprinting technique for promoting corneal regeneration is also discussed.

show abstract

Indications for keratoplasty in management of corneal ectasia

Cited by 3 publications

References 39 publications

Comparison of keratoplasty outcomes at the scar versus edema stages of keratoconus

Comparison of keratoplasty outcomes at the scar versus edema stages of keratoconus

Ocular surface inflammation and ectatic corneal disorders

Bioprinted Membranes for Corneal Tissue Engineering: A Review

Contact Info

Product

Resources

About