Indications for Blood Transfusion in Pregnancy With Sickle Cell Disease

El-Shafei, Affaf M.; Dhaliwal, Jagjeevan Kaur; Sandhu, Amarjeet Kaur; Al-Sharqi, Mona Rashid

doi:10.1111/j.1479-828x.1995.tb02153.x

Cited by 49 publications

(18 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 As this systematic review demonstrates, maternal mortality in a majority of women with SCD occurred in the setting of vaso-occlusive pain episodes, 14,18,28 with pulmonary embolism and acute chest syndrome accounting for 2 additional cases each. 14,28 The positive impact of prophylactic transfusion on maternal morbidity may thus be the consequence of reducing the frequency of vaso-occlusive pain episodes.…”

Section: Discussionmentioning

confidence: 99%

“…19,28 Seven studies specified outcomes based on b-globin genotype. 10,15,18,19,26,28,30 Confounding variables were generally not addressed in the study design or analysis.…”

Section: Description Of Study Characteristicsmentioning

confidence: 99%

“…13 Furthermore, reports assessing the effect of prophylactic RBC transfusions on pregnancy outcomes in SCD have been inconsistent. [14][15][16][17][18][19] Thus, the objective of this study was to systematically review the impact of prophylactic transfusion compared with on-demand transfusion (defined as transfusion instituted to treat complications) on maternal and neonatal adverse pregnancy outcomes in pregnant women with SCD.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prophylactic transfusion for pregnant women with sickle cell disease: a systematic review and meta-analysis

Malinowski

Shehata

D’Souza

et al. 2015

Blood

View full text Add to dashboard Cite

Key Points• Prophylactic transfusion in pregnant women with SCD may reduce maternal mortality, vaso-occlusive pain events, and pulmonary complications.• Prophylactic transfusion in pregnant women with SCD may similarly reduce perinatal mortality, neonatal death, and preterm birth.Pregnancy in women with sickle cell disease is associated with adverse maternal and neonatal outcomes. Studies assessing the effects of prophylactic red blood cell transfusions on these outcomes have drawn inconsistent conclusions. The objective of this systematic review was to assess the effect of prophylactic compared with on-demand red blood cell transfusions on maternal and neonatal outcomes in women with sickle cell disease. A systematic search of several medical literature databases was conducted. Twelve studies involving 1291 participants met inclusion criteria. , and preterm birth (9 studies, 1123 participants; OR, 0.59; 95% CI, 0.37-0.96). Event rates for most of the results were low. Prophylactic transfusions may positively impact several adverse maternal and neonatal outcomes in women with sickle cell disease; however, the evidence stems from a relatively small number of studies with methodologic limitations. A prospective, multicenter, randomized trial is needed to determine whether the potential benefits balance the risks of prophylactic transfusions. (Blood. 2015;126(21):2424-2435

show abstract

Section: Discussionmentioning

confidence: 99%

“…19,28 Seven studies specified outcomes based on b-globin genotype. 10,15,18,19,26,28,30 Confounding variables were generally not addressed in the study design or analysis.…”

Section: Description Of Study Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prophylactic transfusion for pregnant women with sickle cell disease: a systematic review and meta-analysis

Malinowski

Shehata

D’Souza

et al. 2015

Blood

View full text Add to dashboard Cite

show abstract

“…For Koshy et al [23], systematic transfusion would be appreciated prior to 28 weeks of amenorrhea for patients with a history of perinatal mortality, preeclampsia, acute chest syndrome, stroke or severe anemia; to reduce the risk of infection and alloimmunization, which complicate subsequent transfusions. But for El Shafei et al [25], systematic transfusion cannot improve the obstetric prognosis.…”

Section: Discussionmentioning

confidence: 99%

Delivery Outcome in Women with Major Sickle Cell Syndrome: A Comparative Study of the Homozygous Forms “SS” versus the Heterozygous “SC”

Adama-Hondegla¹,

Aboubakari²,

Logbo-Akey³

et al. 2015

OJOG

View full text Add to dashboard Cite

Objectives: To determine the prevalence of women who delivered in the two major sickle cell syndromes, "SS" and "SC", and to identify maternal and early neonatal prognosis inherent to each form. Material and Methods: This is a comparative, descriptive and retrospective cross-sectional study of 226 files of women carrying major sickle cell syndrome (66 cases of "SS" form versus 160 cases of "SC" form), collected from May 2008 to May 2013 at the Gynecology and Obstetrics Clinic of the Sylvanus Olympio's University Hospital of Lomé. Data were processed by Epi Info 6 software. For comparison of variables, the Chi-2 test of Fisher with significance as p < 0.05 has been used, so is the calculation of Odds Ratio with its confidence interval at 95%. Results: Carriers of the two major sickle cell syndromes represent 0.8% of all the deliveries during the study period. Caesarean section, especially prophylactic one, was the dominant mode of delivery. The SS forms have been exposed to have more vaso-occlusive crises (22.7% vs. 13.1%; p = 0.04, OR = 0.31), more blood transfusion (57.6% vs. 29.4%; p = 7 × 10 −5 , OR = 3.2) and more puerperal infections (p < 0.05). Acute chest syndrome was not related to any of the two forms of sickle cell disease (13.6% vs. 8.1%; p = 0.15). The maternal mortality rate and the perinatal mortality among SS form against SC form were not significant (respectively 15.1% vs. 8.7%; 20.9% vs. 17.1%). Conclusion: Maternal and fetal complications were present in both forms of major sickle cell syndrome but the "SS" form gave exposure to greater maternal morbidity. Resuscitative measures in adults and newborns should be reinforced at the delivery time of these "at-risk-pregnancies".

show abstract

“…The literature is rather contradictory regarding the effectiveness of exchange transfusion on maternal and fetal morbidity. Some authors found that routine transfusion does not improve obstetric outcomes [9] [10]. They do advocate this practice if there are particular medical history or in certain clinical settings.…”

Section: Discussionmentioning

confidence: 99%

Preventive Exchange Blood Transfusion in Pregnant Women with Sickle Cell Disease: Maternal and Perinatal Prognosis in a Country with Limited Resources, Burkina Faso

Zamané¹,

Kaïn²,

Kiemtoré³

et al. 2016

OJOG

View full text Add to dashboard Cite

Context: In pregnant women with sickle cell disease, the management with exchange transfusion could be useful in improving the prognosis of mother and child by reducing the level of hemoglobin S less than 40%. Objective: To analyze the maternal and perinatal outcome during the program of the exchange transfusion in pregnant women with sickle cell disease. Patients and Methods: We conducted a prospective study over a period of 18 months. Pregnant women with a major form of sickle cell disease were included. A manual blood exchange transfusion was performed monthly. We monitored the occurrence of maternal and perinatal morbidity during the follow-up. Results: A total of 42 pregnant women with sickle cell disease were monitored. The frequency of infectious episodes and vaso-occlusive crisis was significantly reduced, respectively from 47.6% and 83.3% before the beginning of the blood exchanges transfusion to 11.9% and 16.7% during blood exchanges transfusion program. All newborns were alive at birth with an Apgar score higher or equal to 7 at the 5 th minute. The rate of admission of the newborns at neonatal intensive care

show abstract

Indications for Blood Transfusion in Pregnancy With Sickle Cell Disease

Cited by 49 publications

References 13 publications

Prophylactic transfusion for pregnant women with sickle cell disease: a systematic review and meta-analysis

Prophylactic transfusion for pregnant women with sickle cell disease: a systematic review and meta-analysis

Delivery Outcome in Women with Major Sickle Cell Syndrome: A Comparative Study of the Homozygous Forms “SS” versus the Heterozygous “SC”

Preventive Exchange Blood Transfusion in Pregnant Women with Sickle Cell Disease: Maternal and Perinatal Prognosis in a Country with Limited Resources, Burkina Faso

Contact Info

Product

Resources

About