Indications for and results of single, bilateral, and heart-lung transplantation for pulmonary hypertension

Bando, Ko; Armitage, John; Paradis, Irvin L.; Hardesty, Robert L.; Konishi, Hiroaki; Komatsu, Katsuya; Stein, Keith L.; Shah, Ajit N.; Bahnson, Henry T.; Griffith, Bartley P.

doi:10.1016/s0022-5223(94)70148-2

Cited by 144 publications

(65 citation statements)

References 16 publications

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“…Inwieweit eine genauere immunologische Differenzierung Erfolg verspricht, ist aus der aktuellen Daten-und Studienlage nicht abzuleiten. Inwieweit Organkonservierung, Häufigkeit von Infekten und akuten Abstoßungsreaktionen Einfluss haben, ist ebenfalls nicht in allen Punkten eindeutig [9,23,51,97]. Eine mögliche Therapieoption besteht im Wechsel der Immunsuppression [61,87].…”

Section: Letalität Und Langzeitprognoseunclassified

Spezielle Therapieformen

Bölcskei¹,

Dreher²,

Ellis³

et al. 2008

Klinische Pneumologie

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Section: Letalität Und Langzeitprognoseunclassified

Spezielle Therapieformen

Bölcskei¹,

Dreher²,

Ellis³

et al. 2008

Klinische Pneumologie

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“…Combined heart-lung transplantation (20), single lung transplantation (21)(22)(23) and double lung transplantation (7,21) have each been performed successfully for PAH. While combined heart-lung transplant may provide some advantages during the immediate postoperative period by minimising the concerns of haemodynamic instability associated with the failing right heart, this operation is not necessary for long-term functional and survival improvement.…”

Section: Type Of Transplantmentioning

confidence: 99%

Lung transplantation for pulmonary hypertension

Orens

2007

International Journal of Clinical Practice

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Lung transplantation is an accepted therapeutic intervention for patients with pulmonary arterial hypertension (PAH) who fail medical therapy. Highly selected candidates with PAH may enjoy improved survival by combining medical therapy with transplantation. Despite the known benefits of lung transplantation that include improvement in haemodynamics, exercise tolerance, shortness of breath and long-term survival, this intervention is associated with significant shortcomings. These include, the need for lifelong immunosuppression, and the morbidity associated with the increased risk for infection and allograft rejection. To maximise the potential outcomes of lung transplantation, candidates should be selected based on the international guidelines developed by a consensus panel of experts in the field (J Heart Lung Transplant, 25, 2006, 745). Early referral to a centre with expertise in the management of PAH and transplantation increases the chances of achieving the best possible long-term outcome for patients with this devastating disease.

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“…After single lung transplantation almost the entire cardiac output passes through the allograft while ventilation remains evenly distributed. [14][15][16][17] This is well tolerated provided that minimal allograft dysfunction is present. In the face of reperfusion injury, infection, or rejection, significant hypoxemia results from increased ventilation perfusion mismatch.…”

Section: Timing Of Referral For Transplantation and Of Proceduresmentioning

confidence: 99%