Indications and efficacy of canakinumab in Familial Mediterranean Fever: report of three cases

Tsinti, Maria; Tsitsami, Elena

doi:10.1186/1546-0096-12-s1-p253

Cited by 2 publications

(1 citation statement)

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“…For this reason, further studies evaluating IgG subgroups would be helpful in FMF patients. Tsinti et al reported that a patient with FMF who had frequent URTI had lymphopenia and low serum IgG, IgA, and IgM levels [ 22 ]; the laboratory values improved after switching colchicine to canakinumab.…”

Section: Discussionmentioning

confidence: 99%

High Respiratory Tract Infection Rate in Patients With Familial Mediterranean Fever

Hangül¹,

Akman²,

Koyun³

et al. 2022

Cureus

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BackgroundFamilial Mediterranean fever (FMF) is a systemic autoinflammatory disease genetically transmitted with the autosomal recessive trait. Although the pathogenesis is not certain, it is known that there is a deficiency in the regulation of the natural immune system. In this study, we aimed to search whether patients with FMF are predisposed to respiratory tract infections and whether mannose-binding lectin (MBL), as a natural immune system member, contributes to it. MethodsFifty FMF patients and 20 control groups were enrolled in the study. First, the frequencies of upper respiratory tract infection (URTI) within the previous year of both patient and control groups were evaluated retrospectively. Then, both groups were followed up for URTI for one year after starting the study. The patient's immunoglobulin A (IgA), IgM, IgG, C-reactive protein (CRP), hemogram parameters, and mannosebinding lectin were evaluated. ResultsThe median frequency of annual URTI with a retrospective evaluation of patients was higher than that of the control group. Also, the median frequency of URTI with the prospective evaluation of patients with FMF was higher than the control group. The rate of patients with low serum IgG levels was higher in the patient group than in the control group. However, serum IgG levels of FMF patients with frequent URTI were not different from those without. The median MBL levels of both groups were similar (1312 vs. 1534 ng/ml for the patient and control group, respectively). The rate of patients having low serum MBL levels was also similar between the groups. ConclusionsIn the present study, we found that patients with FMF had more URTI than healthy controls. However, the underlying cause is not fully explained. There is a need for further studies with a higher number of patients evaluating URTI in patients with FMF.

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Section: Discussionmentioning

confidence: 99%