Indications and characteristics of penile traction and vacuum erection devices

Sultana, Abida; Grice, Peter; Vukina, Josip; Pearce, Ian; Modgil, Vaibhav

doi:10.1038/s41585-021-00532-7

Cited by 14 publications

(8 citation statements)

References 70 publications

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“…In addition to the five treatments listed above, VEDs are recommended for patients who have infrequent sexual intercourse and have co-morbidities that require non-invasive, drug-free treatment [ 63 ]. Published data show that regardless of the cause of ED, VED has a 90% efficacy rate in erectile satisfaction with intercourse, with satisfaction rates ranging from 27% to 94% [ 64 ].…”

Section: Hydrogels Could Be the New Expectation For The Repairment Of...mentioning

confidence: 99%

Advanced hydrogels: New expectation for the repair of organic erectile dysfunction

Ren

Yuan

Xue

et al. 2023

Materials Today Bio

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Section: Hydrogels Could Be the New Expectation For The Repairment Of...mentioning

confidence: 99%

Advanced hydrogels: New expectation for the repair of organic erectile dysfunction

Ren

Yuan

Xue

et al. 2023

Materials Today Bio

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“…This method can bypass the limitations of oral drugs and directly achieve an artificial erection, but it requires a normal and intact cavernous nerve to produce an erection ( Lin and Wang, 2013 ; Beaudreau et al, 2021 ). Compared to other penile rehabilitation therapies, VED therapy has the advantages of being non-invasive and having fewer systemic side effects ( Brison et al, 2013 ; Sultana et al, 2022 ) ( Figure 2 ).…”

Section: Physical Therapy Of Edmentioning

confidence: 99%

“…About 25% of the patients in a study reported some physical discomfort during and after use of the device ( Beaudreau et al, 2021 ). According to some studies, the negative pressure suction device also brings some psychological discomfort to patients, such as frustration and lack of autonomy ( Brison et al, 2013 ; Lin and Wang, 2013 ; Beaudreau et al, 2021 ; Ma et al, 2021 ; Sultana et al, 2022 ).…”

Section: Physical Therapy Of Edmentioning

confidence: 99%

Advances in physical diagnosis and treatment of male erectile dysfunction

Pang

Pan

et al. 2023

Front. Physiol.

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Erectile dysfunction (ED) is the most common male sexual dysfunction by far and the prevalence is increasing year after year. As technology advances, a wide range of physical diagnosis tools and therapeutic approaches have been developed for ED. At present, typical diagnostic devices include erection basic parameter measuring instrument, erection hardness quantitative analysis system, hemodynamic testing equipment, nocturnal erection measuring instrument, nerve conduction testing equipment, etc. At present, the most commonly used treatment for ED is pharmacological therapy represented by phosphodiesterase five inhibitors (PDE5i). As a first-line drug in clinical, PDE5i has outstanding clinical effects, but there are still some problems that deserve the attention of researchers, such as cost issues and some side effects, like visual disturbances, indigestion, myalgia, and back pain, as well as some non-response rates. Some patients have to consider alternative treatments. Moreover, the efficacy in some angiogenic EDs (diabetes and cardiovascular disease) has not met expectations, so there is still a need to continuously develop new methods that can improve hemodynamics. While drug have now been shown to be effective in treating ED, they only control symptoms and do not restore function in most cases. The increasing prevalence of ED also makes us more motivated to find safer, more effective, and simpler treatments. The exploration of relevant mechanisms can also serve as a springboard for the development of more clinically meaningful physiotherapy approaches. Therefore, people are currently devoted to studying the effects of physical therapy and physical therapy combined with drug therapy on ED. We reviewed the diagnosis of ED and related physical therapy methods, and explored the pathogenesis of ED. In our opinion, these treatment methods could help many ED patients recover fully or partially from ED within the next few decades.

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“…During clinical practice, physiotherapies, such as vacuum erection devices (VEDs) and shock wave therapy (SWT), have been widely used to treat ED patients. VED relies on negative pressure to draw blood into the penis, and repeated application has been shown to improve ED 1 , 3 , 6 , 7 . SWT consists of noninvasive low-intensity sound waves that pass through erectile tissue, restoring natural erectile function 3 , 8 .…”

Section: Introductionmentioning

confidence: 99%

The role of mechano-regulated YAP/TAZ in erectile dysfunction

Chen

Shu

et al. 2023

Nat Commun

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Phosphodiesterase type 5 inhibitors (PDE5is) constitute the primary therapeutic option for treating erectile dysfunction (ED). Nevertheless, a substantial proportion of patients, approximately 30%, do not respond to PDE5i treatment. Therefore, new treatment methods are needed. In this study, we identified a pathway that contributes to male erectile function. We show that mechano-regulated YAP/TAZ signaling in smooth muscle cells (SMCs) upregulates adrenomedullin transcription, which relaxed the SMCs to maintain erection. Using single-nucleus RNA sequencing, we investigated how penile erection stretches the SMCs, inducing YAP/TAZ activity. Subsequently, we demonstrate that YAP/TAZ plays a role in erectile function and penile rehabilitation, using genetic lesions and various animal models. This mechanism relies on direct transcriptional regulation of adrenomedullin by YAP/TAZ, which in turn modulates penile smooth muscle contraction. Importantly, conventional PDE5i, which targets NO-cGMP signaling, does not promote erectile function in YAP/TAZ-deficient ED model mice. In contrast, by activating the YAP/TAZ-adrenomedullin cascade, mechanostimulation improves erectile function in PDE5i nonrespondent ED model rats and mice. Furthermore, using clinical retrospective observational data, we found that mechanostimulation significantly promotes erectile function in patients irrespective of PDE5i use. Our studies lay the groundwork for exploring the mechano-YAP/TAZ-adrenomedullin axis as a potential target in the treatment of ED.

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Indications and characteristics of penile traction and vacuum erection devices

Cited by 14 publications

References 70 publications

Advanced hydrogels: New expectation for the repair of organic erectile dysfunction

Advanced hydrogels: New expectation for the repair of organic erectile dysfunction

Advances in physical diagnosis and treatment of male erectile dysfunction

The role of mechano-regulated YAP/TAZ in erectile dysfunction

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