Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus)

Dawirs, Ralph R.; Teuchert-Noodt, Gertraud; Molthagen, Martin

doi:10.1016/0014-2999(93)90937-d

Cited by 16 publications

(8 citation statements)

References 47 publications

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“…This lesion is permanent and initiates a whole sequence of responses in the PFC, i.e. dynamic structural and physiological changes in postsynaptic prefrontal pyramidal cells, and significant alterations in the afferent input spectrum of these cells in which GABAergic neurons play an important part (Dawirs et al, , 1993a(Dawirs et al, , 1995. Thus, a single dose of methamphetamine is a non-invasive experimental tool to acutely stimulate prefrontal DA-functions which may lead to reorganization of neuronal networks in the PFC.…”

Section: Discussionmentioning

confidence: 98%

“…Therefore, it is necessary to investigate further effects of DAergic deafferentiation on prefrontal neurogenesis (cf. Lewis et al, 1992;Dawirs et al, 1993aDawirs et al, , 1995. Since mesoprefrontal DA-systems modulate the spontaneous activity of postsynaptic prefrontal pyramidal cells (Mora et al, 1976;Ferron et al, 1984), any change in ontogenesis of these prefrontal target cells, including further afferent systems, might also affect the maturation of prefrontal control over various subcortical systems (cf.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, a single dose of methamphetamine is a non-invasive experimental tool to acutely stimulate prefrontal DA-functions which may lead to reorganization of neuronal networks in the PFC. Besides this, a single methamphetamine impact has been proposed as a reliable pharmacological model to simulate stress-induced selective stimulation of the mesoprefrontal DA-system in mammals (for recent discussion see Dawirs et al, 1993a).…”

Section: Discussionmentioning

confidence: 99%

“…is sufficient to acutely induce selective autotoxic destruction of specific subpopulations of prefrontal DAergic fibres . Further, this single pharmacological challenge was found to be a stimulus strong enough to initiate synaptic and neuronal reorganization in the PFC of adult animals (Dawirs et al, , 1993a. In order to investigate in which way and to what extent neonatal disturbance of prefrontal DA-functions might influence subsequent neurogenesis of the PFC, we have quantitatively evaluated the postnatal maturation of the prefrontal DA innervation both during undisturbed development and following an early single dose of methamphetamine (Dawirs et al, 1993b(Dawirs et al, , 1994.…”

Section: Introductionmentioning

confidence: 98%

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Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus)

Dawirs

Teuchert-Noodt

Czaniera

1996

J. Neural Transmission

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A single dose of methamphetamine (50 mg/kg; i.p.) was administered to neonatal male gerbils (Meriones unguiculatus) aged 14 days, and adult prefrontal cortex (PFC)-related behaviours were analysed and compared with saline-treated controls at the age of postnatal day 90. For that purpose, animals were tested for open-field activities and y-maze delayed alternation. This solitary and non-invasive drug challenge, which has recently been found to initiate serious restraint in maturation of the mesoprefrontal dopamine (DA)-system (Dawirs et al., 1994), induces a significant delayed alternation impairment as well as significant increases in open-field motor activity and emotionality. Since an undisturbed development of the prefrontal DA-innervation seems to be a precondition for the maturation of normal PFC-related behaviours, a single early methamphetamine impact may be a suitable animal model for further investigation of structural and functional aspects of non-invasively induced behavioural deficits in rodents. The present results are discussed with regard to the assumption that hypofunctional mesoprefrontal DA-systems might be basic to schizophrenic behaviours in man.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus)

Dawirs

Teuchert-Noodt

Czaniera

1996

J. Neural Transmission

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“…The drug challenge caused an acute increase of spine densities at the dendrites of postsynaptic pyramidal cells (Dawirs et al, 1991). In long-terms, the initally degraded pyramids recovered and were exposed to prominent spine dynamics at all dendrites which, in the course of 30 days, resulted in a slight but significant drop of spine densities as compared to controls (Dawirs et al, 1993b). Additionally, the pyramidal cells were faced with an increase of GABAergic synaptic profiles .…”

Section: Manipulations Of Developmental Plasticity In the Prefrontal mentioning

confidence: 99%

Advances in Research on Neurodegeneration

2000

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This work is subject to copyright. AII rights are reserved, whether the whole Of part of the material is concemed, specificalIy those of tran slation, reprinting, re-use of ilIustrations, broadcasting, reproduction by photocopying machines or similar means, and storage in data banks. Product Liability: The publisher can give no guarantee for alI the information contained in this book. This does also refer to information about drug dosage and application thereof. In every individual case the respective user must check its accuracy by con sulting other pharmaceuticalliterature. The use of registered names, trademarks, etc . in thi s publication doe s not imply, even in the absence of specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.

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Social environment alters both ontogeny of dopamine innervation of the medial prefrontal cortex and maturation of working memory in gerbils (Meriones unguiculatus)

1998

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Male gerbils (Meriones unguiculatus) were bred and reared either grouped under enriched environmental conditions or isolated under impoverished environmental conditions. The objective of the present study was to examine the influence of social environment on structural and functional ontogeny of the medial prefrontal cortex (mPFC). In this respect, we investigated the maturation of both prefrontal dopamine (DA) innervation and working memory. For that purpose, at the age of postnatal day 90, prefrontal DA fibers were stained immunocytochemically using an antibody against glutaraldehyde-conjugated DA and innervation density was determined by means of a computer controlled program for image analysis. In order to evaluate environmental effects on working memory, 90-day-old gerbils were tested for y-maze delayed alternation. It was found that, isolation produced a significant and severe restraint of the maturation of prefrontal DA innervation, leading to fiber densities which were 56% below those in group-reared gerbils. Isolation also induced a significant impairment of delayed alternation performance on the y-maze indicating that obvious deficits in working memory had developed under restricted rearing conditions. The present results are discussed with regard to activity-dependent postnatal maturation of the cortex and adaptive neuroplasticity.

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Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus)

Cited by 16 publications

References 47 publications

Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus)

Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus)

Advances in Research on Neurodegeneration

Social environment alters both ontogeny of dopamine innervation of the medial prefrontal cortex and maturation of working memory in gerbils (Meriones unguiculatus)

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