Indication of liver transplantation in severe alcoholic liver cirrhosis: quantitative evaluation and optimal timing

Perceptions of post-transplant recidivism in liver transplantation for alcoholic liver disease

“…This is presumably because the criteria allow observations needed to determine the recovery odds from potential liver failure [7,14,15] and prevent posttransplant alcoholic recidivism [16][17][18][19][20] . In addition, there is a preponderance of evidence supporting that a pretransplant abstinence period of six months has become a mandatory selection criterion [8,[11][12][13][19][20][21] , as its benefit was reported by Bird et al [6] in 1990.…”

“…In addition, there is a preponderance of evidence supporting that a pretransplant abstinence period of six months has become a mandatory selection criterion [8,[11][12][13][19][20][21] , as its benefit was reported by Bird et al [6] in 1990. However, there are also reports indicating that an abstinence period of more than six months is not a significant predictive factor for alcoholic recidivism [22][23][24] , along with those demonstrating that LT candidates with ALD barely survive for six months even with no alcohol intake [15,23] . A solid validation for requiring pre-transplant abstinence, as well as optimal duration of abstinence, if necessary, has yet to be established.…”

Palliative long-term abdominal drains in refractory ascites due to end-stage liver disease: A case series

“…Unresponsiveness to, or intolerance of, diuretics [refractory ascites, (RA)] is a poor prognostic sign in ESLD; without liver transplantation (LT) median life expectancy is six months (2, 3). We and others have shown less than ten percent of patients with advanced cirrhosis are eligible for LT due to comorbidity, alcohol recidivism, substance misuse and psychosocial issues (1,4). Thus in many with RA and ESLD the management remains palliative.…”

The Role of Liver Transplantation in theTreatment of Alcoholic Liver Disease

“…First, the period of pretransplantation abstinence may allow liver recovery, even to the extent of a LT becoming unnecessary, with one study showing significant improvement within 3 months (Veldt et al, 2002). Second, it can help identify those patients unable to abstain, and thus more likely to relapse after the LT.…”