Indication for treatment and long-term outcome of focal nodular hyperplasia

Abstract

The cohort was divided into two groups of patients: those who were managed surgically (n=15) and those managed conservatively (n=37). There was no correlation between tumour size and number of lesions with oral contraceptive use (p=0.07 and 0.90, respectively) and pregnancy (p=0.45 and 0.60, respectively). However, tumour size (p=0.006) and number of lesions (p=0.02) were associated with the occurrence of pain in these patients. Pain was the commonest symptom of patients (13/15) who were managed surgically. All patients underwent radiological imaging before diagnosis. The sensitivities of ultrasound, CT scanning and MRI scanning in characterizing these lesions were 30%, 70% and 87%, respectively. There were no postoperative deaths and three postoperative complications that were successfully managed non-operatively. With a median follow-up of 24 months in the surgically treated group, one patient has developed recurrent symptoms of pain. CONCLUSION. In this series, there was no mortality directly due to the surgical procedure and a modest morbidity, justifying surgical resections in selected patients.

Focal Nodular Hyperplasia—A Review of Myths and Truths

“…Unfortunately, there was no follow-up information about persistent pain postoperatively in the 13 patients who underwent resection when the preoperative indication for surgery was pain. 60 In a retrospective series analysing eight patients with symptomatic FNH who underwent resection, symptoms were relieved in all of these patients at a median of 24 months follow-up. 61 Laparoscopic liver resection may provide additional benefits over open resection in terms of postoperative hospital stay and early return to normal activities (Fig.…”

Focal nodular hyperplasia in pediatric allogeneic hematopoietic cell transplant: case series

“…2,[5][6][7][8][9][10] It can occur at all ages but it is typically found in women during their reproductive years. 8 The incidence of FNH as a complication of allogeneic HSCT is unknown.…”

Should Focal Nodular Hyperplasia Still be Operated Upon? Analysis of a Case Series

“…Classically, the incidence of surgery in patients with presumed FNH remains approximately 21.6-51.4% [6,[11][12][13][14][15]. There are 2 main reasons for this high incidence.…”