Indicadores antropométricos de adiposidade abdominal na doença hepática gordurosa não alcoólica

Abstract

Objective: To analyze the influence of intra-abdominal fat (IAF) and subcutaneous fat (SF) on nonalcoholic fatty liver disease (NAFLD). Methods: Clinical, prospective and survey study, with data collected at an ultrasound reference center in Aracaju-SE. The following variables were evaluated: age, IAF and SF in relation to the non-alcoholic hepatic steatosis variable diagnosed by abdominal ultrasound. The collection process was divided into three stages. The quantitative variables IAF and SF did not show adherence to Normal and Kruskal-Wallis test was used for multiple comparisons and the Dunn test with a significance level considered p <0.05. The data obtained were analyzed using software R, version 3.6.1. Results: 250 patients were evaluated, of both sexes, with a mean age of 44.83 (± 15.05) years, of these, 12 were excluded, totaling a final sample of 238 patients. Regarding the degrees of hepatic fatty infiltration, 54.3% of patients were classified as grade 0, 20.6% as grade 1, 21% grade 2 and 3.8% grade 3. It was shown that there was a statistically significant association between the degrees of non-alcoholic hepatic steatosis and the increase in stratified abdominal fat at intra-abdominal and subcutaneous sites. Conclusion: There was a significant association between degrees of non-alcoholic liver steatosis and subcutaneous and intra-abdominal fats. IAF and SF proved to be relevant factors in the severity of non-alcoholic fatty liver steatosis.

Diabete Mellitus e ascite na esteatose hepática não alcoólica

“…Neste contexto, a relação entre a DHGNA e o diabetes tipo 2 é bidirecional e mutuamente prejudicial, considerando que ambas possuem fatores de risco e patogênese comuns, como obesidade, resistência à insulina e dislipidemia. 2 Além disso, existem outros fatores que contribuem para o desenvolvimento da doença, como quadro de inflamação crônica, de estresse oxidativo, de disfunção mitocondrial e de alterações no microbioma intestinal. 3 Nessa perspectiva, apesar dos mecanismos de coexistência entre as duas patologias não serem totalmente elucidadas, pacientes com diabetes tipo 2 possuem, de forma geral, a resistência à insulina como principal fator.…”