Indicaciones de la dexmedetomidina en las tendencias actuales de sedoanalgesia en el paciente crítico

Ortega, Marcos; Jambrina, C. Chamorro; Vallhonrat, Inés Lipperheide; Simón, I. Fernández

doi:10.1016/j.medin.2013.03.008

Cited by 22 publications

(4 citation statements)

References 47 publications

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“…Premedicación La intervención inicia con ketamina (12 mg/kg/dosis) vía intramuscular (I.M), diazepam (0,05 mg/kg/dosis) vía I.M. Se puede adicionar de manera optativa dexmedetomidina 0,2 mcg/kg vía I.M, dependiendo del estado de agitación del animal (22) . El objetivo es llegar a una «inmovilización farmacológica» y optimizar el manejo del sujeto.…”

Section: Fase Previa a La Ventilación Mecánicaunclassified

Protocolo de prueba de ventilador mecánico para atención de pacientes con COVID-19 en modelo porcino

García-Castro

Latorre-Galeano

Giraldo-Montoya

et al. 2021

Rev Peru Med Exp Salud Publica

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A raíz de la pandemia generada por el SARS-CoV-2, los sistemas de salud de los distintos países han experimentado un dramático aumento en la ocupación de las unidades de cuidado intensivo y, por ende, una alta demanda de ventiladores mecánicos. En este artículo se propone un protocolo de pruebas de ventiladores mecánicos de bajo costo en modelos porcinos, como parte del desarrollo de equipos biomédicos que pueden apoyar la crisis sanitaria suscitada por la pandemia. El protocolo aborda aspectos que incluyen la fase previa a la prueba, el manejo anestésico, de vía aérea, seguimiento de laboratorio, recuperación y seguimiento del animal. Como resultado, se presenta a la comunidad académica un protocolo de validación de prototipo de ventilador mecánico en espécimen porcino como un referente para su aplicación y revalidación por parte de grupos interesados en el desarrollo de tecnologías locales de bajo costo.

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Section: Fase Previa a La Ventilación Mecánicaunclassified

Protocolo de prueba de ventilador mecánico para atención de pacientes con COVID-19 en modelo porcino

García-Castro

Latorre-Galeano

Giraldo-Montoya

et al. 2021

Rev Peru Med Exp Salud Publica

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“…Actually, this drug is only indicated in patients with mechanical ventilation, but its mechanism of action (‘conscious sedation’), is promising. [3]…”

Section: Consequencesmentioning

confidence: 99%

Sleep quality in intensive care unit: Are we doing our best for our patients?

Romero-Bermejo¹

2014

Indian Journal of Critical Care Medicine

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“…Dexmedetomidine is a highly selective α2-adrenergic receptor agonist, its sedation and analgesic effects are similar to opioids, and are suitable for short-term or long-term sedation in the intensive care environment [7][8][9]. Dexmedetomidine induces a dose-dependent effect, but this sedation is reversible, patient is easily awakened to a waking state [10][11][12], it is reported that Dexmedetomidine application may result in postoperative comorbidities including uncontrollable hypotension, severe bradycardia and hypocardia etc. [13 , 14], especially when Dexmedetomidine is used via continuous epidural anesthesia, the risk of its complications increased [15].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Evaluation Between Dexmedetomidine and Midazolam for Intraoperative Sedation in the Elderly: Protocol for a Systematic Review and Meta-analysis of Randomized Controlled Trials

Huang¹,

Li²,

Long³

et al. 2021

Preprint

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Background: The sedative effect of intraoperative sedation in elderly surgery exerts critical influence on the prognosis. Comparison on the safety and efficacy between Dexmedetomidine and Midazolam in many clinical randomized controlled trials (RCTs) were inconsistent and suspicious. We aimed to comprehensively evaluate the safety and efficacy between Dexmedetomidine and Midazolam for intraoperative sedation in the elderly via meta-analysis and systematic reviews.Methods: RCTs regarding to the comparison of sedative effects and safety between Dexmedetomidine and Midazolam in elderly patients (aged ≥ 60 years) will be comprehensively searched from 2000.10 to 2021.05 through 4 English databases and 4 Chinese databases. After extraction in duplicate, the systematic review and meta-analysis will be performed on the primary outcomes (hemodynamic changes, sedative effect, cognitive function) and secondary outcomes (analgesic effect, surgical characteristics, complications or adverse reactions) for assessing the two therapy methods using Review manage software (Version 5.3). Sensitivity analysis will be conducted to evaluate the heterogeneity of the results, funnel plot and Egger’s test will be performed to analyze publication bias of the included studies, and test sequential analysis will be applied to assess the robustness and reliability of preliminary meta-analysis results. Finally, rating quality of evidence and strength of recommendations on the meta results will be summarized by rating quality of evidence and strength of recommendations (GRADE) approach. Discussion: This systematic review and meta-analysis will evaluate the safety and efficacy between Dexmedetomidine and Midazolam for intraoperative sedation in the elderly, it will give an insight on the application of Dexmedetomidine and Midazolam, and will provide evidences-based reference for clinical decision makings.Systematic review registration: PROSPERO (CRD42021221897).

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Indicaciones de la dexmedetomidina en las tendencias actuales de sedoanalgesia en el paciente crítico

Cited by 22 publications

References 47 publications

Protocolo de prueba de ventilador mecánico para atención de pacientes con COVID-19 en modelo porcino

Protocolo de prueba de ventilador mecánico para atención de pacientes con COVID-19 en modelo porcino

Sleep quality in intensive care unit: Are we doing our best for our patients?

A Comprehensive Evaluation Between Dexmedetomidine and Midazolam for Intraoperative Sedation in the Elderly: Protocol for a Systematic Review and Meta-analysis of Randomized Controlled Trials

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