2011
DOI: 10.1111/j.1472-8206.2011.01011.x
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Indian herbal medicines in the treatment of liver diseases: problems and promises

Abstract: Plant drugs are known to play a major role in the management of liver diseases. There are many plants and their extracts that have been shown to possess hepatoprotective activities. There are more than 300 preparations in Indian system of medicine for the treatment of jaundice and chronic liver diseases. About 600 commercial herbal formulations with claimed hepatoprotective activity are being sold all over the globe. The active phytochemical fraction that imparts hepatoprotective activity has been identified i… Show more

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Cited by 54 publications
(30 citation statements)
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“…However, most of these compounds were not sufficiently evaluated in humans. A wide variety of plant constituents, including silymarin, resveratrol, curcumin, quercetin, and glycyrrhizin, have been reported to have multiple biological activities, mainly due to their antioxidant and antiinflammatory properties (Alvari et al, 2012;Dhiman et al, 2012;Ding et al, 2012;Girish & Pradhan, 2012;Muriel & Rivera-Espinoza, 2008;Zhang et al, 2013a). The present article focuses on only few well-studied naturally occurring hepatoprotective (cytoprotective) compounds.…”
Section: In Vitro and In Vivo Experimental Hepatotoxic Models In Livementioning
confidence: 99%
See 2 more Smart Citations
“…However, most of these compounds were not sufficiently evaluated in humans. A wide variety of plant constituents, including silymarin, resveratrol, curcumin, quercetin, and glycyrrhizin, have been reported to have multiple biological activities, mainly due to their antioxidant and antiinflammatory properties (Alvari et al, 2012;Dhiman et al, 2012;Ding et al, 2012;Girish & Pradhan, 2012;Muriel & Rivera-Espinoza, 2008;Zhang et al, 2013a). The present article focuses on only few well-studied naturally occurring hepatoprotective (cytoprotective) compounds.…”
Section: In Vitro and In Vivo Experimental Hepatotoxic Models In Livementioning
confidence: 99%
“…In addition to our personal experience, we have performed a literature search using mainly Web of Science (WOS), PubMed, and Google search. An extensive number of articles which address many plant constituents with reported experimental (in vitro or in vivo) effects are summarized in various reviews (Alvari et al, 2012;Dhiman et al, 2012;Ding et al, 2012;Girish & Pradhan, 2012;Muriel & Rivera-Espinoza, 2008;Zhang et al, 2013a). In this article, we only consider literature related to the most widely studied active plant constituents of chemically defined molecules with potential hepatoprotective activity and the models most commonly used for their validation.…”
Section: Aim Of the Articlementioning
confidence: 99%
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“…These herbs generally have strong antioxidative potential and cause induction of antioxidant enzymes like superoxide dismutase, reduced glutathione and catalase. The mechanisms of hepato-protection include stimulation of heme oxygenase-1 activity, inhibition of nitric oxide production, hepatocyte apoptosis and nuclear factor-κB activation [20]. Saman grita like Panchagabya grita, Rohitaka grita, Panchakola grita, Amalaki grita are described in Ayurveda for treatment of liver diseases.…”
Section: Ayurveda Literature In Hepato Biliary Disordersmentioning
confidence: 99%
“…There are several herbal formulations used for their hepatoprotective activity in the traditional system of medicine in India and China. 1 However, only a small proportion of these herbal preparations have been evaluated scientifically in animal and clinical studies. Eclipta alba grows commonly in moist places as a weed all over the world.…”
Section: Introductionmentioning
confidence: 99%