2006
DOI: 10.1038/ng1874
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Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus

Abstract: The hedgehog family of morphogens are regulators of cell proliferation, differentiation and cell-cell communication. These morphogens have been shown to have important roles in organogenesis, spermatogenesis, stem cell maintenance and oncogenesis. Indian hedgehog (encoded by Ihh) has been shown to be expressed in the uterine epithelium under the control of the steroid hormone, progesterone. Although in vivo and in vitro studies have shown that progesterone achieves its effects on uterine function through epith… Show more

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Cited by 252 publications
(309 citation statements)
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“…However, implantation sites were observed in 6 of 9 WT but only 0 of 6 in UtEpiαERKO after natural mating or embryo transfer into pseudopregnant females, indicating that UtEpiαERKO mice have a compromised uterine embryo receptivity. Accordingly, the estrogen-regulated transcripts Lif (leukemia inhibitory factor) and Ihh (Indian hedgehog), which are essential for embryo attachment (23,24), remained unchanged in UtEpiαERKO but were up-regulated in WT after E 2 treatment (Fig. S2).…”
Section: Resultsmentioning
confidence: 99%
“…However, implantation sites were observed in 6 of 9 WT but only 0 of 6 in UtEpiαERKO after natural mating or embryo transfer into pseudopregnant females, indicating that UtEpiαERKO mice have a compromised uterine embryo receptivity. Accordingly, the estrogen-regulated transcripts Lif (leukemia inhibitory factor) and Ihh (Indian hedgehog), which are essential for embryo attachment (23,24), remained unchanged in UtEpiαERKO but were up-regulated in WT after E 2 treatment (Fig. S2).…”
Section: Resultsmentioning
confidence: 99%
“…3 A and B). The expressions of Pgr-regulated genes Indian hedgehog (Ihh) (18), amphiregulin (Areg) (19), homobox A10 (Hoxa10) (20), nuclear receptor subfamily 2, group F, member 2 (Nr2f2) (18), and heart and neural crest derivatives expressed transcript 2 (Hand2) (21) were significantly decreased, and E2 target genes mucin 1 (Muc1), Muc4, lactotransferrin (Ltf), and complement component 3 (C3) (21,22) were significantly increased in OEx mice compared with control mice (Fig. 3 C and D).…”
Section: N1icd Overexpression Mice Are Completely Infertile Because Omentioning
confidence: 99%
“…P 4 signaling inhibits the estrogen signaling pathways in the uterus (Hsueh et al 1975) and this inhibitory relationship involving both hormone pathways orchestrate the regulatory mechanisms required for endometrial receptivity and embryo implantation. Amongst the regulated transcripts in the mid-secretory endometrium from women with mifepristone administration we found several genes involved in the P 4 signaling axis including modulators and effectors with down regulation of NCOA2 (SRC-2, (Mukherjee et al 2006, Jeong et al 2007), IHH (Matsumoto et al 2002, Takamoto et al 2002, ERRFI1 (MIG6, (Kim et al 2010)) PTCH1 (Lee et al 2006) and DKK1 ; and up-regulation of ESR1 (Curtis et al 1999), PRA (Conneely & Lydon 2000), FKBP5 (Tranguch et al 2005), FOXO1A (Kim et al 2005), KLF9 (Simmen et al 2004) and PTGS1 (Wang et al 2004).…”
Section: Discussionmentioning
confidence: 99%