Indian culinary plants enhance glucose-induced insulin secretion and glucose consumption in INS-1 β-cells and 3T3-L1 adipocytes

Kaur, Lovedeep; Han, Kyoung-Sik; Bains, Kiran; Singh, Harjinder

doi:10.1016/j.foodchem.2011.05.089

Cited by 10 publications

(6 citation statements)

References 27 publications

(28 reference statements)

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“…Compound 5 was obtained as a white, amorphous solid. The HRESIMS showed an [M + H] + ion at m/z 768.3076, which together with the 13 C NMR data indicated a molecular formula of C 36 H 49 NO 17 . The 1 H NMR data (Table 2) of 5 were similar to those of 1, with the main differences being the resonances of the two olefinic protons at δ H 6.66 (d, J = 12.5 Hz) and δ H 5.86 (d, J = 12.5 Hz) relative to the signals of an E-double bond in 1, which suggested the presence of a (Z)-N-4-coumaroyltyramine moiety in 5.…”

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confidence: 85%

“…16 The fully differentiated 3T3-L1 adipocytes were preincubated with serum-free high-glucose DMEM for 12 h in 48-well plates as previously reported. 17 The adipocytes were incubated with or without the test compounds, as well as with insulin (0.1 μM), for an additional 24 h. The levels of glucose consumption were determined as previously described.…”

Section: Journal Of Natural Productsmentioning

confidence: 99%

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Antihyperglycemic Glucosylated Coumaroyltyramine Derivatives from Teucrium viscidum

Zhu

Luo

et al. 2014

J. Nat. Prod.

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Eight new glucosylated coumaroyltyramine derivatives, teuvissides A-H (1-8), were isolated from whole plants of Teucrium viscidum. Their structures were elucidated using spectroscopic data and chemical methods. The antihyperglycemic activities of these compounds were evaluated in HepG2 cells and 3T3-L1 adipocytes, and all of the isolates elicited different levels of glucose consumption at a concentration of 2.0 μM. Teuvissides A (1), B (2), and F (6) induced 2.2-, 2.1-, and 2.2-fold changes, respectively, in the levels of glucose consumption in HepG2 cells and 2.5-, 2.1-, and 2.3-fold changes, respectively, in 3T3-L1 adipocytes relative to the basal levels.

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mentioning

confidence: 85%

Section: Journal Of Natural Productsmentioning

confidence: 99%

Antihyperglycemic Glucosylated Coumaroyltyramine Derivatives from Teucrium viscidum

Zhu

Luo

et al. 2014

J. Nat. Prod.

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“…The content of total soluble sugars is negligible -0.1-1.4 g/100 g [Gajera et al, 2018;Ghosh et al, 2017]. Moreover, jamun seeds were recognized as the rich source of dietary fiber [Kaur et al, 2011], which together with lignin constituted non-digestible carbohydrates and represented nutritionally important, health-promoting food ingredient. The content of total dietary fiber of jamun seeds was evaluated at 27.7 g/100 g and the fraction of insoluble dietary fiber was significantly greater than that of the soluble dietary fiber (24.9 g/100 g and 2.8 g/100 g, respectively) [Kaur et al, 2011].…”

Section: Carbohydratesmentioning

confidence: 99%

“…Moreover, the jamun seeds have been found to contain nutrients. They are rich in carbohydrates, dietary fiber, ascorbic acid, and some minerals [Benherlal & Arumughan, 2007;Ghosh et al, 2017;Kaur et al, 2011]. The nutritional and phytochemical profiles of jamun seeds revealed that they could be a novel source for pharmaceutical and food industries.…”

Section: Introductionmentioning

confidence: 99%

Jamun Seed: A Review on Bioactive Constituents, Nutritional Value and Health Benefits

Tak¹,

Kaur²,

Jain³

et al. 2022

Pol. J. Food Nutr. Sci.

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Jamun fruit, a member of the Myrtaceae family, is commercially grown in tropical and subtropical areas of the world for its fruits with sweet, sour, and astringent luscious flesh. Seeds of jamun fruits are discarded as trash during the industrial processing of fruit pulp into beverages, jellies, jam, vinegar, wine, and squash. These seeds are a potential source of bioactive compounds including hydrolysable tannins, phenolic acids, flavonoids, other phenolics, terpenoids, phloroglucinol derivatives and saponins, which have been endorsed several biological activities, such as antidiabetic, anticancer, anti-inflammatory, antioxidant, antimicrobial, antihyperlipidemic and antihypercholesterolemic, as well as cardioprotective, hepatoprotective and neuroprotective properties. High contents of carbohydrates, dietary fiber, minerals, and ascorbic acid have also been found in jamun seeds. However, potential utilization of these seeds as innovative implements for health benefits has not yet been fully understood. We aim to compile scientific research and recent advances on jamun seed nutritional profile, bioactive compounds composition, bioactive properties, and their potential as an ingredient in functional food formulation.

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“…[140] Ficus religiosa L. (Moraceae) contains phytosterols, amino acids, furanocoumarins, phenolic components, hydrocarbons, aliphatic alcohols, volatile components, and few other classes of secondary metabolites, which are strong antidiabetic in nature. [141] ISO is a plant C-glycosyl flavonoid which shows strong antidiabetic effects but its mechanisms of action is unknown [ Table 1]. [128] Similarly, ethanol extract of Melothria heterophylla (EEMH) contains rutin (RU) and gallic acid (GA) EEMH, GA which demonstrated remarkable antidiabetic activity in STZ-induced diabetic rats.…”

Section: Bio-organic Compounds Thymoquinone (Tq)mentioning

confidence: 99%

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2016

IJGP

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The present review explains the use of natural plant products for therapeutics of diabetes. It is a serious metabolic disorder that imposes multiple effects on human health. Although diabetes is curable, an erratic lifestyle always make panic and causes disease severity if proper medication is not being made available. Several ethnomedicines have been used by local people in form of crude extracts prepared from flowers, fruits, and roots of endemic plant species for cure of diabetes. There is a common usage of herbal parts for preparation of concoctions, syrups, vegetables, juices, green tea, from leaves, and roots for therapeutic purposes. This article explains antidiabetic effects of various plant secondary metabolites such as anthraquinones, flavonoids, secoiridoids, iridoids, flavanones, biophenols, triterpenes, benzoic acid derivatives, isochromans, and phytosterols. Daily meals containing good nutraceuticals such as protein and fiber can replace carbohydrate food that is a main source of glucose. Mainly, herbal foods rich in flavanols and polyphenols show hypoglycemic effects and can be used in the prevention of diabetes-induced vascular dysfunctions. Antidiabetic plant natural products restore insulin level and increase utilization of external glucose. Herbal dietary supplementation having diverse antioxidants, fibers, minerals, and antiglycants show inhibitory activity against α-amylase and α-glycosidase can easily control carbohydrate metabolism in humans. No doubt plant origin natural products can be used as alternative medicine for treatment of diabetes, but they must need proper composition and formulation before being used.

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Indian culinary plants enhance glucose-induced insulin secretion and glucose consumption in INS-1 β-cells and 3T3-L1 adipocytes

Cited by 10 publications

References 27 publications

Antihyperglycemic Glucosylated Coumaroyltyramine Derivatives from Teucrium viscidum

Antihyperglycemic Glucosylated Coumaroyltyramine Derivatives from Teucrium viscidum

Jamun Seed: A Review on Bioactive Constituents, Nutritional Value and Health Benefits

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