Index of convexity: A novel method for assessing liver functional reserve using technetium-99m-galactosyl human serum albumin liver scintigraphy

Sato, Takafumi; Arita, Junichi; Inoue, Yosuke; Koga, Rintaro; Takahashi, Yu; Saiura, Akio

doi:10.5582/bst.2017.01014

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…4 Similarly, technetium-99m-diethylenetriaminepentaacetic acid-galactosyl-human serum albumin (Tc-GSA scintigraphy) in nuclear medicine study correlates with liver function. 5 Hence, Gd-EOB-DTPA and Tc-GSA evaluate hepatic disorder by uptake into hepatocytes. [6][7][8] Previously, DWI has been used to evaluate inflammation and fibrosis, 9 where an apparent diffusion coefficient (ADC) value is significantly reduced in advanced fibrosis and inflammation, such as cirrhotic liver.…”

Section: Bjrmentioning

confidence: 99%

Diffusion kurtosis imaging in the assessment of liver function: Its potential as an effective predictor of liver function

Yoshimaru

Takatsu

Suzuki

et al. 2019

BJR

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InTroDucTIon Currently, liver function is evaluated using various blood parameters, such as serum albumin and serum bilirubin levels, or biochemical classifications, such as Child-Pugh and albumin-bilirubin (ALBI) scores. However, it is impossible to evaluate focal liver disorders using such blood parameters because the results indicate the function of the entire liver. In particular, a specific part of the liver that has impaired function cannot be evaluated. Alternatively, hepatic state changes in the whole liver can be evaluated by image assessment using MRI or nuclear medicine study. MRI systems, such as MR elastography, 1,2 dynamic

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Section: Bjrmentioning

confidence: 99%

Diffusion kurtosis imaging in the assessment of liver function: Its potential as an effective predictor of liver function

Yoshimaru

Takatsu

Suzuki

et al. 2019

BJR

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“…Further, given that scintigraphy uses a rapidly decaying isotope, it is extremely difficult to simultaneously standardize the GSA dose and the radioactivity on a patient-by-patient basis. To counter these problems, an attempt was made to use the degree of convexity of TAC as an index [10,11]; however, it is still a fairly intuitive parameter that does not consider the radioactivity derived from receptor nonbinding 99m Tc-GSA in the hepatic blood pool. A graphical approach to calculate the uptake rate constant has also been reported [12][13][14], and although it is theoretically appropriate, this calculation method is unlikely to be adopted in today's digital era.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of Liver Uptake Rate Constant in 99mTc-GSA Scintigraphy for the Risk Stratification of Patients Undergoing Hepatectomy: A New Method for Calculation

et al. 2022

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Introduction: The use of technetium 99m diethylenetriaminepentaacetic acid-galactosyl human serum albumin (99mTc-GSA) scintigraphy parameters, HH15 and LHL15, in assessing the future liver remnant function is not expedient because of their nonlinear behaviour against liver volume. Uptake rate constant for the binding of 99mTc-GSA to asialoglycoprotein receptors is probably more favourable, but the reported calculation methods are complex. We devised a simple method to calculate the uptake rate constant, KrGSA. Methods: Radioactivity counts for the entire liver and heart regions were extracted at 10, 20, and 30 min. Using whole liver and heart volumes measured from single-photon emission computed tomography images, free radioactivity corresponding to the liver blood pool was subtracted. The time activity curve was fitted to the equation L(t) = L(∞) × [1 − Exp (−kt)] using Microsoft Office Excel (add-in free programme Solver)®, where L(∞) is the count at plateau level and k denotes KrGSA. Results: KrGSA values accurately identified liver cirrhosis and were similar to the KICG. The areas under the curve for KrGSA and KICG in the receiver operating characteristic analysis were 0.808 and 0.795, respectively, and a good correlation was seen between KrGSA and KICG. Discussion/Conclusion: KrGSA can be utilized as an alternative to KICG in assessing the future liver remnant function.

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Hepatectomy with Perioperative Chemotherapy for Multiple Colorectal Liver Metastases is the Available Option for Prolonged Survival

et al. 2022

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Index of convexity: A novel method for assessing liver functional reserve using technetium-99m-galactosyl human serum albumin liver scintigraphy

Cited by 5 publications

References 28 publications

Diffusion kurtosis imaging in the assessment of liver function: Its potential as an effective predictor of liver function

Diffusion kurtosis imaging in the assessment of liver function: Its potential as an effective predictor of liver function

Usefulness of Liver Uptake Rate Constant in <sup>99m</sup>Tc-GSA Scintigraphy for the Risk Stratification of Patients Undergoing Hepatectomy: A New Method for Calculation

Hepatectomy with Perioperative Chemotherapy for Multiple Colorectal Liver Metastases is the Available Option for Prolonged Survival

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