Independent risk factors of mortality in patients with sepsis receiving single-dose etomidate as an induction agent during rapid sequence intubation in a large tertiary emergency department in Thailand

Abstract

Background There is limited evidence regarding factors associated with mortality in septic patients receiving etomidate. This study aimed to determine independent pre-intubation factors predicting 28-day mortality in septic patients receiving single-dose etomidate as an induction agent during rapid sequence intubation (RSI). Methods This single-center retrospective cohort study included intubated septic patients receiving etomidate as an induction agent during RSI in the emergency department of Siriraj hospital, Bangkok, Thailand, between January 1st, 2016 and June 30th, 2020. Pre-intubation characteristics were compared between survivors and non-survivors. Independent risk factors associated with 28-day mortality were identified using the Cox proportional hazards regression model. Association between etomidate dosage and mortality was also determined. Results A total of 344 patients, 238 (69%) survivors and 106 (31%) non-survivors, were included in the analyses. The initial Cox hazards model identified a pre-intubation lactate level ≥ 4 mmol/L as an independent factor associated with mortality (adjusted Hazards ratio [aHR] 2.66, 95% confidence interval [CI] 1.55–4.56). After removing lactate level from the model due to limited lactate values in the data, cancer was also predictive of 28-day mortality (aHR 1.83, 95%CI 1.10–3.04), while patients with respiratory infections and underlying chronic lung disease were associated with lower mortality (aHR 0.54, 95%CI 0.37–0.80 and aHR 0.57, 0.33–0.96, respectively). Etomidate dosage was not associated with mortality in our study. Conclusion In septic patients who received a single dose of etomidate, a pre-intubation lactate level ≥ 4 mmol/L and cancer were associated with increased 28-day mortality, while respiratory infection and underlying chronic lung disease were associated with lower mortality. Physicians may take these factors into consideration when selecting induction agents for septic patients.

Factors Associated with Postintubation Hypotension Among Patients with Suspected Sepsis in Emergency Department

“…Moreover, Smischney et al 8 also found that every 10-year increase in age increased the incidence of PIH by 1.33 times. Concordance with previous study, 17 higher lactate levels are not only associated with the severity of sepsis but also an increasing odds for PIH, accounting for a 2.00-times higher odds if the lactate level is >4.4 mmol/L.…”

LASSO-Based Identification of Risk Factors and Development of a Prediction Model for Sepsis Patients

“…While medical scientists and clinical experts agree that certain key factors can serve as prognostic indicators for sepsis, 13 different studies have identified varying high-risk factors. 14 , 15 In our study, we examined data from a cohort of 1733 septic patients and identified ten variables (MV requirement, HF requirement, NE requirement, Septicemia, MDR, thrombocytopenia, RDW-CV, CRP, AT III, and APTT) that exhibited the strongest associations with sepsis-related mortality using Lasso regression. When combined to form a predictive model, these variables yielded an AUC of 0.801.…”