Independent prognostic role of human papillomavirus genotype in cervical cancer

Abstract

BackgroundAlthough the correlation of HPV genotype with cervical precursor lesions and invasive cancer has been confirmed, the role of HPV genotype in cervical cancer prognosis is less conclusive. This study aims to systematically investigate the independent prognostic role of HPV genotype in cervical cancer.MethodsA total of 306 eligible patients provided cervical cell specimens for HPV genotyping before therapy and had a median follow-up time of 54 months after diagnosis. Survival times were measured from the date of diagnosis to the date of cervical cancer-related death (overall survival, OS) and from the date of diagnosis to the date of recurrence or metastasis (disease free survival, DFS). Log-rank tests and Cox proportional hazard models were performed to evaluate the association between HPV genotype and survival times.ResultsA total of 12 types of high-risk HPV were detected and the leading ten types belong to two species: alpha-9 and alpha-7. HPV16 and 18 were the two most common types, with the prevalence of 60.8% and 8.8%, respectively. In the univariate analysis, HPV16-positive cases were associated with better OS (P = 0.037) and HPV16-related species alpha-9 predicted better OS and DFS (both P < 0.01). After adjusting for age, FIGO stage, and therapy, HPV16 showed a hazard ratio (HR) of 0.36 (95% CI: 0.18, 0.74; P = 0.005) for OS, and alpha-9 resulted in a HR of 0.17 (95% CI: 0.08, 0.37; P < 0.001) for OS and 0.32 (95% CI: 0.17, 0.59; P < 0.001) for DFS.ConclusionsHPV genotype poses differential prognoses for cervical cancer patients. The presence of HPV16 and its related species alpha-9 indicates an improved survival.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-017-2465-y) contains supplementary material, which is available to authorized users.

Telomere length in cervical exfoliated cells, interaction with HPV genotype, and cervical cancer occurrence among high‐risk HPV‐positive women

“…HPV16 and 18 are the most frequent types in both cases and controls worldwide, while HPV52 and 58 are the most frequent types in both cases and controls in China. Our previous study also found that HPV 16, 18, 52, and 58 were the most common types causing cervical cancer among Chinese women . Only a minority of HR‐HPV infections become persistent and finally produces cancerous lesions, suggesting other factors (eg, host immunity and genetic susceptibility) might affect the carcinogenesis .…”

“…Our previous study also found that HPV 16,18,52, and 58 were the most common types causing cervical cancer among Chinese women. [3][4][5][6] Only a minority of HR-HPV infections become persistent and finally produces cancerous lesions, suggesting other factors (eg, host immunity and genetic susceptibility) might affect the carcinogenesis. 7 It might take 10-15 years from the initial HR-HPV infection to cancer appearance, 8 thus allowing sufficient time for potential cervical screening.…”

HPV Genotypes of Senegalese Women Attending Radiotherapy

“…For example, HPV16 is associated with a higher level of tumor apoptosis than HPV18, affording one possible explanation for more radiosensitive cervical cancer with HPV16 [33].…”

Low Necroptosis Process Predicts Poor Treatment Outcome of Human Papillomavirus Positive Cervical Cancers by Decreasing Tumor-Associated Macrophages M1 Polarization

“…However, some studies showed that HPV DNA did not have any prognostic implication [8,9]. Furthermore, existing results on the relationship of HPV genotype with survival are also heterogeneous [4,10]. Therefore, identifying new molecular targets was needed to improve the prognosis and quality of life of patients with cervical cancer.…”

“…The major cause of invasive cervical cancer is persistent infection with high-risk human papillomavirus (HR-HPV). More than 170 genotypes have been described, and 2 HPV species, alpha-7 (HPV 18, 39, 45, 59, 68, and 70) and alpha-9 (HPV 16, 31, 33, 35, 52, 58, and 67), are classified as high-risk geno-DOI: 10.1159/000487434 types due to their high oncogenic potential [4]. Although there has been much evidence on the role of HPV in cervical precursor lesions and invasive cancer, it remains controversial how they affect prognosis of cervical cancer.…”