Independent inverse relationship between serum lycopene concentration and arterial stiffness

Kim, Oh Yoen; Yoe, Hyun Yang; Kim, Hyae Jin; Park, Ju Yeon; Kim, Ji Young; Lee, Sang Hak; Lee, Jin Hee; Lee, Kang Pyo; Jang, Yangsoo; Lee, Jong Ho

doi:10.1016/j.atherosclerosis.2009.08.009

Cited by 63 publications

(54 citation statements)

References 31 publications

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“…Recently, brachial-ankle pulse wave velocity (baPWV) has been suggested to be a marker of arterial stiffness, oxidative stress, and inflammation useful to identify the subjects with early atherosclerotic change. In a population study, including 264 healthy women enrolled from the CardiovascularAging Control Study, Kim et al [146], investigated the relationship between serum lycopene concentrations and early atherosclerosis assessed by baPWV measurements. The results of the study support the presence of an independent inverse relationship between serum lycopene concentrations and baPWV, a marker for early atherosclerotic change.…”

Section: Epidemiological Studiesmentioning

confidence: 99%

Lycopene and Cardiovascular Diseases: An Update

Mordente

Guantario²,

Meucci³

et al. 2011

CMC

145

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Cardiovascular disease (CVD) is the leading cause of death in Western societies and accounts for up to a third of all deaths worldwide. In comparison to the Northern European or other Western countries, the Mediterranean area has lower rates of mortality from cardiovascular diseases and cancer, and this is attributed, at least in part, to the so-called Mediterranean diet, which is rich in plantderived bioactive phytochemicals. Identification of the active constituents of the Mediterranean diet is therefore crucial to the formulation of appropriate dietary guidelines. Lycopene is a natural carotenoid found in tomato, an essential component of the Mediterranean diet, which, although belonging to the carotenoid family, does not have pro-vitamin A activity but many other biochemical functions as an antioxidant scavenger, hypolipaemic agent, inhibitor of pro-inflammatory and pro-thrombotic factors, thus potentially of benefit in CVD. In particular, the review intends to conduct a systematic analysis of the literature (epidemiological studies and interventional trials) in order to critically evaluate the association between lycopene (or tomato products) supplementation and cardiovascular diseases and/or cardiovascular disease risk factors progression, and to prepare provision of evidence-based guidelines for patients and clinicians. Several reports have appeared in support of the role of lycopene in the prevention of CVD, mostly based on epidemiological studies showing a dose-response relationship between lycopene and CVD. A less clear and more complex picture emerges from the interventional trials, where several works have reported conflicting results. Although many aspects of lycopene in vivo metabolism, functions and clinical indications remain to be clarified, supplementation of low doses of lycopene has been already suggested as a preventive measure for contrasting and ameliorating many aspects of CVD.

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Section: Epidemiological Studiesmentioning

confidence: 99%

Lycopene and Cardiovascular Diseases: An Update

Mordente

Guantario²,

Meucci³

et al. 2011

CMC

145

View full text Add to dashboard Cite

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“…[129][130][131] Many of these blood markers and others (such as lycopene, uric acid, adiponectin) have been related to increased arterial stiffness and may also have value in monitoring arterial stiffness in smokers and former smokers. 39,94,95,[132][133][134][135][136][137] However, it has been suggested that the use of multiple blood markers is of little prognostic value, 96,138 and that even the use of single markers such as C-reactive protein or homocysteine did not improve prediction of outcome using the Framingham risk score. 138 Perhaps simply measuring cfPWV and AIx may prove the simplest and most effective method to assess and monitor vascular health in smokers.…”

Section: Mechanismsmentioning

confidence: 99%

The effect of smoking on arterial stiffness

et al. 2010

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A systematic literature review was conducted using PubMed, Embase and the Cochrane Library to determine the effect of acute, chronic and passive smoking on arterial stiffness and to determine whether these effects are reversible after smoking cessation. A total of 39 relevant studies were identified and included. Acute smoking was found to cause an acute increase in arterial stiffness. Similarly, passive smoking increased arterial stiffness acutely and chronically. The majority of studies identified chronic smoking as a risk factor for increasing arterial stiffness. However, some studies found no statistical difference in arterial stiffness between nonsmokers and long-term smokers, although chronic smoking seems to sensitize the arterial response to acute smoking. In addition, whether arterial stiffness is reversed after smoking cessation and the timeline in which this may occur could not be determined from the identified literature. The effect of smoking discontinuation on arterial stiffness remains to be established by prospective smoking cessation trials.

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“…16 The average baPWV from both left and right sides was used for analysis. The ABI was measured using VP-1000 vascular profiler (Nippon Colin Ltd.) in subjects before at least 15-minute supine rest (the time of measurement was not specialized).…”

Section: Measurement Of Bapwv and Abimentioning

confidence: 99%