Independent Impact of Gynoid Fat Distribution and Free Testosterone on Circulating Levels of N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) in Humans

Chlabicz, Małgorzata; Jamiołkowski, Jacek; Paniczko, Marlena; Sowa, Paweł; Łapińska, Magda; Szpakowicz, Małgorzata; Jurczuk, Natalia; Kondraciuk, Marcin; Raczkowski, Andrzej; Sawicka, Emilia; Kamiński, Karol

doi:10.3390/jcm9010074

Cited by 16 publications

(13 citation statements)

References 54 publications

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“…The male gender was dominant in PC-AKI patients (70.06% (N = 110) vs. 53.74 (N = 4229), p < 0.001). They more often had atrial fibrillation (37.58% (N = 59) vs. 19.85 (N = 1562), p < 0.001), chronic kidney disease (42.68% (N = 67) vs. 19.85 (N = 1562), p < 0.001), lower mean ejection fraction (41.53 (SD = 16.97) vs. 50.43 (SD = 13.29), p < 0.001), and were also more likely to have significant stenosis (58.6% (N = 92) vs. 39.94 (N = 3144), p < 0.001). In addition, patients with PC-AKI were more often treated with NOAC (p = 0.03) and VKA (p = 0.008) anticoagulants (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…The incidence of atrial fibrillation has increased over the last years and will continue to increase in the coming ones, giving us an estimated 17.9 million cases in Europe by 2060 [ 4 , 18 ]. There are a number of factors that determine the origin of AF from hypertension, valvular defects, diabetes, hyperthyroidism to heart failure and coronary artery disease [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

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Atrial Fibrillation and Chronic Kidney Disease—A Risky Combination for Post-Contrast Acute Kidney Injury

Kuźma

Tomaszuk‐Kazberuk

Kurasz

et al. 2021

JCM

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Atrial fibrillation (AF) symptoms may mimic coronary artery disease (CAD) which reflects the difficulties in qualifying AF patients for invasive diagnostics. A substantial number of coronary angiographies may be unnecessary or even put patients at risk of post-contrast acute kidney injury (PC-AKI), especially patients with chronic kidney disease (CKD). We aimed to investigate the hypothesis indicating higher prevalence of PC-AKI in patients with AF scheduled for coronary angiography. The study population comprised of 8026 patients referred for elective coronarography including 1621 with AF. In the comparison of prevalence of PC-AKI in distinguished groups we can see that kidney impairment was twice more frequent in patients with AF in both groups with CKD (CKD (+)/AF (+) 6.24% vs. CKD (+)/AF (−) 3.04%) and without CKD (CKD (−)/AF (+) 2.32% vs. CKD (−)/AF (−) 1.22%). In our study, post-contrast acute kidney disease is twice more frequent in patients with AF, especially in subgroup with chronic kidney disease scheduled for coronary angiography. Additionally, having in mind results of previous studies stating that AF is associated with non-obstructive coronary lesions on angiography, patients with AF and CKD may be unnecessarily exposed to contrast agent and possible complications.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Atrial Fibrillation and Chronic Kidney Disease—A Risky Combination for Post-Contrast Acute Kidney Injury

Kuźma

Tomaszuk‐Kazberuk

Kurasz

et al. 2021

JCM

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“…The body composition was measured by dual energy x-ray absorptiometry (DEXA) (GE Healthcare, Chicago, IL, USA) as described previously [ 16 ]. The A/G ratio was calculated between the fat of the android (central) and fat of the gynoid (hip and thigh) regions.…”

Section: Methodsmentioning

confidence: 99%

A Similar Lifetime CV Risk and a Similar Cardiometabolic Profile in the Moderate and High Cardiovascular Risk Populations: A Population-Based Study

Chlabicz

Jamiołkowski

Łaguna

et al. 2021

JCM

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Background: Cardiovascular disease (CVD) is a major, worldwide problem that remains the dominant cause of premature mortality in the world, and increasing rates of dysglycaemia are a major contributor to its development. The aim of this study was to investigate the cardiometabolic profile among patients in particular cardiovascular risk classes, and to estimate their long term CV risk. Methods: A total of 931 individuals aged 20–79 were included. The study population was divided into CV risk classes according to the latest European Society of Cardiology recommendations. Results: Most of the analyzed anthropometric, body composition and laboratory parameters did not differ between the moderate and high CV risk participants. Interestingly, estimating the lifetime risk of myocardial infarction, stroke or CV death, using the LIFEtime-perspective model for individualizing CardioVascular Disease prevention strategies in apparently healthy people, yielded similar results in moderate and high CV risk classes. Conclusion: The participants who belonged to moderate and high CV risk classes had very similar unfavorable cardiometabolic profiles, which may result in similar lifetime CV risk. This may imply the need for more aggressive pharmacological and non-pharmacological management of CV risk factors in the moderate CV risk population, who are often unaware of their situation. New prospective population studies are necessary to establish the true cardiovascular risk profiles in a changing society.

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“…The body composition was measured by dual energy x-ray absorptiometry (DEXA) (GE Healthcare, Chicago, Illinois, USA). The gynoid (G) fat (GF) and lean (GL), android (A) fat (AF) and lean (AL), legs (L) fat (LF) and lean (LL) were measured automatically as described previously 13 . Fat mass index (FMI), lean mass index (LMI) and visceral mass index (VMI) were calculated as fat, lean and visceral mass in kilograms divided by height in meters squared.…”

Section: Data Collection and Assaysmentioning

confidence: 99%

Subjective Well-being in Non-obese Individuals Depends Strongly on Body Composition

Chlabicz

Paniczko

Jamiołkowski

et al. 2021

Preprint

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While obesity has been correlated with welfare in the general population, there is not much data on the influence of body composition on welfare among the non-obese adult individuals. A total of 726 non-obese individuals from general population were analyzed. The mean age was 46.8±15.4 years and 42.1% of participants were male. The mean value for Satisfaction with Life Scale (SWLS) was 23.09±5.43, for Euro Quality of Life Visual Analogue Scale (EQ-VAS) was 78.0±14.5, and for Beck Depression Inventory (BDI) was 6.7±6.6. On SWLS the waist-hip ratio had a negative impact even after adjustment for age, gender and concomitant diseases. EQ-VAS was inversely associated with android fat distribution and directly associated with muscle mass. BDI value was inversely associated with lower muscle mass, especially of the lower limbs. The well-being of women was mainly associated with the distribution of adipose tissue and less with the distribution of muscle tissue - abdominal fat distribution has a particularly negative impact on well-being among women. In contrast, men's well-being depends more on muscle mass and to a lesser extent on the distribution of fat tissue - a positive significant effect has lean mass and a circumference of thigh below gluteal fold.

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Independent Impact of Gynoid Fat Distribution and Free Testosterone on Circulating Levels of N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) in Humans

Cited by 16 publications

References 54 publications

Atrial Fibrillation and Chronic Kidney Disease—A Risky Combination for Post-Contrast Acute Kidney Injury

Atrial Fibrillation and Chronic Kidney Disease—A Risky Combination for Post-Contrast Acute Kidney Injury

A Similar Lifetime CV Risk and a Similar Cardiometabolic Profile in the Moderate and High Cardiovascular Risk Populations: A Population-Based Study

Subjective Well-being in Non-obese Individuals Depends Strongly on Body Composition

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