Independent association of severity of obstructive sleep apnea with lipid metabolism of atherogenic index of plasma (AIP) and apoB/apoAI ratio

Cao, Bing; Fan, Zeqin; Zhang, Yanhong; Li, Taoping

doi:10.1007/s11325-020-02016-1

Cited by 13 publications

(17 citation statements)

References 26 publications

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“…Cao et al reported that AIP was higher in OSA and was related to disease severity. 12 These findings were in line with the study by Wysocki et al who reported a direct relationship between AIP and AHI. 13 Shimizu et al found that AIP was related to OSA, but only in normal-weight subjects.…”

Section: Discussionsupporting

confidence: 91%

“…11 To address this, the logarithmic ratio of high-density lipoprotein cholesterol (HDL-C) and triglycerides, the so called Atherogenic Index of Plasma (AIP) has been investigated in OSA before in several studies. [12][13][14][15] In addition, visceral fat distribution was demonstrated to be a better predictor for cardiovascular disease than the body mass index (BMI). 16 In line with this, composite indices which take into account both, lipid parameters and waist circumference, were better predictors for cardiovascular disease than single lipid components.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Composite Lipid Indices in Patients with Obstructive Sleep Apnoea

Bikov¹,

Frent²,

Reisz³

et al. 2022

NSS

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Obstructive sleep apnoea (OSA) is a recognised risk factor for cardiovascular disease. However, it is difficult to evaluate the risk of cardiovascular disease in patients with OSA due to multiple shared risk factors. Composite lipid indices, such as atherogenic index of plasma (AIP), visceral adiposity index (VAI) and lipid accumulation product (LAP) have been shown to predict cardiovascular disease better than their individual lipid components. This study aimed to evaluate these indices in patients with OSA. Patients and Methods: Six hundred sixty-seven (667) patients with OSA and 139 non-OSA control volunteers participated in the study. Fasting serum triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C) levels were measured, and AIP, LAP and VAI were calculated following cardiorespiratory polygraphy. The relationship between lipid parameters, OSA and its comorbidities was evaluated using receiver operating curve (ROC) analysis. Results: We found a significant difference in all lipid parameters between OSA patients and controls. Comparing ROCs, LAP was significantly more strongly associated with OSA compared to all the other parameters. The optimal cut-off value for LAP to detect OSA was 76.4, with a sensitivity of 63% and a specificity of 76%. In addition, LAP was the best parameter to predict hypertension and diabetes in patients with OSA, and it was predictive for ischaemic heart disease together with HDL-C. Conclusion: Our results support the use of LAP in clinical practice when evaluating cardiovascular risk in patients with OSA. However, the optimal cut-off value should be determined in large-scale follow-up studies.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Comparison of Composite Lipid Indices in Patients with Obstructive Sleep Apnoea

Bikov¹,

Frent²,

Reisz³

et al. 2022

NSS

View full text Add to dashboard Cite

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“…The atherogenic index of plasma (AIP) is a biomarker of atherosclerosis and coronary heart disease which is calculated as log(TG/HDL-C) [ 204 ] and reflects the dysregulation between anti- and pro-atherogenic lipoproteins. Previous studies found significantly higher AIP values among participants with OSA compared to the controls [ 205 , 206 , 207 , 208 , 209 ]. AIP was higher in patients with OSA and associated with disease severity [ 206 , 207 , 209 ] and daytime sleepiness in some [ 209 ] but not all studies [ 208 ].…”

Section: Current Knowledge Of the Pathophysiological Lipid Metabolism...mentioning

confidence: 89%

Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia

Mészáros

Bikov

2022

Biomedicines

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Obstructive sleep apnoea (OSA) is associated with cardiovascular and metabolic comorbidities, including hypertension, dyslipidaemia, insulin resistance and atherosclerosis. Strong evidence suggests that OSA is associated with an altered lipid profile including elevated levels of triglyceride-rich lipoproteins and decreased levels of high-density lipoprotein (HDL). Intermittent hypoxia; sleep fragmentation; and consequential surges in the sympathetic activity, enhanced oxidative stress and systemic inflammation are the postulated mechanisms leading to metabolic alterations in OSA. Although the exact mechanisms of OSA-associated dyslipidaemia have not been fully elucidated, three main points have been found to be impaired: activated lipolysis in the adipose tissue, decreased lipid clearance from the circulation and accelerated de novo lipid synthesis. This is further complicated by the oxidisation of atherogenic lipoproteins, adipose tissue dysfunction, hormonal changes, and the reduced function of HDL particles in OSA. In this comprehensive review, we summarise and critically evaluate the current evidence about the possible mechanisms involved in OSA-associated dyslipidaemia.

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“…Since inflammation has the ability to alter RCT, HDL function, and apo A-I, the current study’s findings propose that inflammation might be the main underlying mechanism for the CEC reduction in patients with OSA [ 54 ]. In addition, all CECs presented inverse correlations with AIP which was reported to be higher in patients with OSA [ 55 , 56 ]. These findings suggest that TG/cholesterol ester exchange between HDL and other lipoproteins might be another factor that affected HDL function.…”

Section: Discussionmentioning

confidence: 99%

High-density lipoprotein cholesterol efflux capacity in patients with obstructive sleep apnea and its relation with disease severity

et al. 2022

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Background Obstructive sleep apnea (OSA) is linked to an accelerated risk of cardiovascular disease (CVD). Some key CVD risk factors are present in patients suffering from OSA such as hypertension, inflammation, oxidative stress, and dyslipidemia. High-density lipoprotein (HDL) cholesterol efflux capacity (CEC) is proposed as a reliable biomarker of HDL function and the present study aimed to quantify this biomarker in patients with OSA. Methods ATP binding cassette subfamily A member 1 (ABCA1), non-ABCA1, and total CEC were determined in 69 polysomnographic-confirmed OSA patients and 23 controls. Moreover, paraoxonase (PON) activities, high-sensitivity C-reactive protein (hsCRP), apolipoprotein B (apo B), and apolipoprotein A-I (apo A-I) circulating levels were quantified in the studied population. Results: All CEC measures were reduced in the OSA group compared to the control group. Strikingly, ABCA1 CEC was diminished in severe OSA in comparison with mild OSA. Furthermore, PON activities and apo A-I showed lower levels, while hsCRP and apo B were elevated in OSA patients compared to controls. Moreover, ABCA1 CEC showed an inverse association with hsCRP and a positive association with apo A-I, while non-ABCA1 CEC presented an association with HDL-C. Conclusion These results suggest the presence of an impaired HDL function in OSA. In particular, ABCA1 CEC was associated with disease severity and inflammation which could be a factor increasing the risk of CVD.

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Independent association of severity of obstructive sleep apnea with lipid metabolism of atherogenic index of plasma (AIP) and apoB/apoAI ratio

Cited by 13 publications

References 26 publications

Comparison of Composite Lipid Indices in Patients with Obstructive Sleep Apnoea

Comparison of Composite Lipid Indices in Patients with Obstructive Sleep Apnoea

Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia

High-density lipoprotein cholesterol efflux capacity in patients with obstructive sleep apnea and its relation with disease severity

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