Independent association between insulin‐like growth factor‐I and dehydroepiandrosterone sulphate in women in middle adulthood

Kasayama, Soji; Morita, Shinya; Otsuki, Michio; Asanuma, Nobuyuki; Saitō, Hiroshi; Mukai, Mikio; Koga, Masafumi

doi:10.1111/j.1365-2265.2007.02815.x

Cited by 10 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10,11 Moreover, the dehydroepiandrosterone (DHEA) and IGF-1 levels showed a good correlation. 12 The American College of Sports Medicine (ACSM) Position Stands indicate that usual walking for older adults corresponds approximately to high-intensity exercise for younger people. 13 Additionally, older adults exhibited greater activation of leg muscles for usual walking than young adults.…”

mentioning

confidence: 99%

Mail-Based Intervention for Sarcopenia Prevention Increased Anabolic Hormone and Skeletal Muscle Mass in Community-Dwelling Japanese Older Adults: The INE (Intervention by Nutrition and Exercise) Study

Yamada

Nishiguchi

Fukutani

et al. 2015

Journal of the American Medical Directors Association

View full text Add to dashboard Cite

mentioning

confidence: 99%

Mail-Based Intervention for Sarcopenia Prevention Increased Anabolic Hormone and Skeletal Muscle Mass in Community-Dwelling Japanese Older Adults: The INE (Intervention by Nutrition and Exercise) Study

Yamada

Nishiguchi

Fukutani

et al. 2015

Journal of the American Medical Directors Association

View full text Add to dashboard Cite

“…The GH/IGF‐1 axis plays a key role in ACTH‐dependent synthesis of DHEAS in the adrenal gland [16–18]. IGF‐1 and IGF1R occur in the zona reticularis of the adrenal gland [16].…”

Section: Igf‐1 Stimulates Adrenal and Gonadal Androgen Synthesismentioning

confidence: 99%

“…IGF‐1 and IGF1R occur in the zona reticularis of the adrenal gland [16]. In adults, a positive association has been found between IGF‐1 and serum DHEAS [17]. IGF‐1 increases the sensitivity of the adrenal gland to ACTH and promotes the expression of androgen‐synthesizing enzymes [19, 20].…”

Section: Igf‐1 Stimulates Adrenal and Gonadal Androgen Synthesismentioning

confidence: 99%

Milk consumption: aggravating factor of acne and promoter of chronic diseases of Western societies

Melnik

2009

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Summary Consumption of cow's milk and cow's milk protein result in changes of the hormonal axis of insulin, growth hormone and insulin‐like growth factor‐1(IGF‐1) in humans. Milk consumption raises IGF‐1 serum levels in the perinatal period, adolescence and adulthood. During puberty with the physiological onset of increased secretion of growth hormone, IGF‐1 serum levels increase and are further enhanced by milk consumption. IGF‐1 is a potent mitogen; after binding to its receptor in various tissues, it induces cell proliferation and inhibits apoptosis. Keratinocytes and sebocytes, as well as the androgen‐synthesizing adrenals and gonads, are stimulated by IGF‐1. The epidemic incidence of adolescent acne in Western milk‐consuming societies can be explained by the increased insulin‐ and IGF‐1‐stimulation of sebaceous glands mediated by milk consumption. Acne can be regarded as a model for chronic Western diseases with pathologically increased IGF‐1‐stimulation. Many other organs, such as the thymus, bones, all glands, and vascular smooth muscle cells as well as neurons are subject to this abnormally increased hormonal stimulation. The milk‐induced change of the IGF‐1‐axis most likely contributes to the development of fetal macrosomia, induction of atopy, accelerated linear growth, atherosclerosis, carcinogenesis and neurodegenerative diseases. Observations of molecular biology are supported by epidemiologic data and unmask milk consumption as a promoter of chronic diseases of Western societies.

show abstract

“…Serum DHEAS was measured by radioimmunoassay (DPC DHEA-S kit, Mitsubishi Kagaku Iatron, Tokyo, Japan). Inter-and intra-assay coefficients of variation in this assay were 12.0% and 4.1% at the concentrations of 600 and 650 ng/mL (14). The homeostasis model assessment insulin sensitivity index (HOMA-%S) was calculated from fasting plasma glucose and serum insulin concentrations by using the correct HOMA evaluation and a computer program (15).…”

Section: Laboratory Methodsmentioning

confidence: 99%

Serum Dehydroepiandrosterone Sulphate Levels in Patients with Non-Alcoholic Fatty Liver Disease

et al. 2011

Self Cite

View full text Add to dashboard Cite

Backgound Dehydroepiandrosterone (DHEA) is an adrenal hormone reported to prevent body weight gain, diabetes mellitus and atherosclerosis. We hypothesized that DHEA is involved in the pathophysiology of nonalcoholic fatty liver disease (NAFLD) often associated with obesity and insulin resistance. In this study, we aimed to examine the clinical significance of serum DHEA sulfate (DHEAS) in patients with NAFLD. Methods We determined serum DHEAS, serum alanine aminotransferase (ALT), serum lipids, plasma fasting glucose and insulin levels in 158 Japanese men who had neither viral hepatic diseases nor alcohol intake exceeding 20 g/day. NAFLD was diagnosed by the presence of fatty change of the liver by echotomographic examination. Results Among the study subjects, 69 were diagnosed as having NAFLD. Their serum DHEAS levels were significantly higher than in 89 subjects without NAFLD. Serum DHEAS levels in 19 NAFLD patients with elevated ALT levels (>40 U/L) were significantly higher than in the other 50 NAFLD patients with normal ALT levels (!40 U/L). Multivariate regression analysis demonstrated that serum ALT was positively correlated with serum DHEAS, serum triglyceride and body mass index. Conclusion Serum DHEAS levels are increased in patients with NAFLD with elevated ALT levels. Increased serum DHEAS may be a component of the pathophysiology of NAFLD.

show abstract

Independent association between insulin‐like growth factor‐I and dehydroepiandrosterone sulphate in women in middle adulthood

Abstract: The present study demonstrates that DHEAS and IGF-I levels are associated with each other, independent of age, in women in middle adulthood.

Cited by 10 publications

References 40 publications

Mail-Based Intervention for Sarcopenia Prevention Increased Anabolic Hormone and Skeletal Muscle Mass in Community-Dwelling Japanese Older Adults: The INE (Intervention by Nutrition and Exercise) Study

Mail-Based Intervention for Sarcopenia Prevention Increased Anabolic Hormone and Skeletal Muscle Mass in Community-Dwelling Japanese Older Adults: The INE (Intervention by Nutrition and Exercise) Study

Milk consumption: aggravating factor of acne and promoter of chronic diseases of Western societies

Serum Dehydroepiandrosterone Sulphate Levels in Patients with Non-Alcoholic Fatty Liver Disease

Contact Info

Product

Resources

About