Independent and synergistic activity of the flavonoids of Gracilaria corticata as promising antidiabetic agents

Sangeetha, R.

doi:10.1590/s2175-97902019000418766

Cited by 9 publications

(5 citation statements)

References 14 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The combination of rosmarinic acid and vancomycin may also be effective against MRSA [57]. Numerous epidemiological studies have demonstrated that flavonoids and their glycosides have versatile health benefits [58,59]. It is not surprising that flavonoids have broad-spectrum antibacterial activity both in vitro and in vivo because they are synthesised in response to microbial attacks in plants [60,61].…”

Section: Discussionmentioning

confidence: 99%

Chemical Constituents, Antioxidant Potential, and Antimicrobial Efficacy of Pimpinella anisum Extracts against Multidrug-Resistant Bacteria

et al. 2023

View full text Add to dashboard Cite

Aniseeds (Pimpinella anisum) have gained increasing attention for their nutritional and health benefits. Aniseed extracts are known to contain a range of compounds, including flavonoids, terpenes, and essential oils. These compounds have antimicrobial properties, meaning they can help inhibit the growth of nasty bacteria and other microbes. The purpose of this study was to determine if aniseed extracts have potential antioxidant, phytochemical, and antimicrobial properties against multidrug-resistant (MDR) bacteria. A disc diffusion test was conducted in vitro to test the aniseed methanolic extract’s antibacterial activity. The MIC, MBC, and inhibition zone diameters measure the minimum inhibitory concentration, minimum bactericidal concentration, and size of the zone developed when the extract is placed on a bacterial culture, respectively. HPLC and GC/MS are analytical techniques used for identifying the phenolics and chemical constituents in the extract. DPPH, ABTS, and iron-reducing power assays were performed to evaluate the total antioxidant capacity of the extract. Using HPLC, oxygenated monoterpenes represented the majority of the aniseed content, mainly estragole, cis-anethole, and trans-anethole at 4422.39, 3150.11, and 2312.11 (g/g), respectively. All of the examined bacteria are very sensitive to aniseed’s antibacterial effects. It is thought that aniseed’s antibacterial activity could be attributed to the presence of phenolic compounds which include catechins, methyl gallates, caffeic acid, and syringic acids. According to the GC analysis, several flavonoids were detected, including catechin, isochiapin, and trans-ferulic acid, as well as quercitin rhamnose, kaempferol-O-rutinoside, gibberellic acid, and hexadecadienoic acid. Upon quantification of the most abundant estragole, we found that estragole recovery was sufficient for proving its antimicrobial activity against MDR bacteria. Utilizing three methods, the extract demonstrated strong antioxidant activity. Aniseed extract clearly inhibited MDR bacterial isolates, indicating its potential use as an anti-virulence strategy. It is assumed that polyphenolic acids and flavonoids are responsible for this activity. Trans-anethole and estragole were aniseed chemotypes. Aniseed extracts showed higher antioxidant activity than vitamin C. Future investigations into the compatibility and synergism of aniseed phenolic compounds with commercial antibacterial treatments may also show them to be promising options.

show abstract

Section: Discussionmentioning

confidence: 99%

Chemical Constituents, Antioxidant Potential, and Antimicrobial Efficacy of Pimpinella anisum Extracts against Multidrug-Resistant Bacteria

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Flavonoids are the most effective compounds as scavengers of reactive species, for example super dioxide, peroxyl radicals, and peroxynitrite by transferring H+ atoms [24,30]. According to Sangeetha et al the hydroxyl group is believed to play the most role in the process of solving free radicals because it is capable of carrying out the hydrogen donor process [31]. The mechanism that occurs is that flavonoids are oxidized by radicals, producing radicals that are more stable and less reactive.…”

Section: Effect Of Red Ginger Extract On Sgptmentioning

confidence: 99%

Effect of red ginger extract (Zingiber officinale var. Rubrum) of SGOT and SGPT levels in white rats (Rattus norvegicus) induced by Gentamicine

Ayuni Wardah Humairo,

Moh. Sukmanadi,

M. Gandul Atik Yuliani

et al. 2024

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

Introduction: The aim of the research was to prove that red ginger extract (Zingiber officinale var. Rubrum) could inhibit the increase in SGOT and SGPT levels in Gentamicin-induced rats. Objective: Twenty-five male rats aged 8-12 weeks with 150-200 gram BW divided into five groups research with C- was given CMC-Na 1% and aqua pro-injection, C+ was given 1% CMC-Na and induction of Gentamicin 80 mg/kg BW, and groups T1, T2, and T3 given induction of Gentamicin 80 mg/kg BW and red ginger extract at individual doses each of 100, 200, and 400 mg/kg BW. All treatments were carried out for 15 days. On the 16th day, all rats were euthanized and their blood was drawn intracardiacly, then SGOT and SGPT levels were examined. The results of the research used the Analysis of Variance (ANOVA) and Games-Howell statistical analysis. Results: The results showed that the C+ group experienced the highest increase (p<0.05) while the C-group experienced the lowest increase (p<0.05) compared to the other treatment groups. The T1, T2, T3 groups were able to inhibit the increase in SGOT and SGPT levels. Conclusion: The effective dose to inhibit the increase in SGOT levels is 400 mg/kg BW and the effective dose to inhibit the increase in SGPT levels is 200 mg/kg BW.

show abstract

“…Gracilaria sp. mengandung molekul bioaktif seperti flavonoid yang berperan dalam perbaikan kerusakan jaringan pankreas yang diakibatkan oleh alkilasi DNA pascainduksi STZ (Sangeetha, 2020). Perbaikan kerusakan jaringan dapat dilakukan melalui peningkatan aktivitas antioksidan dengan cara meningkatkan enzim antioksidan seluler seperti superoksida dismutase (SOD), katalase, dan glutation peroksidase (Dewi et al, 2011).…”

Section: Pendahuluanunclassified

Rumput Laut Sango-sango (Gracilaria sp.) Berpotensi Memperbaiki Kondisi Hiperglikemik dan Ekspresi Insulin Pankreas Tikus Diabetik

Bakti,

Handharyani,

Purwaningsih

2023

jveteriner

View full text Add to dashboard Cite

Indonesia menempati urutan kelima dengan penderita diabetes melitus terbanyak di dunia. Manajemen makan harus dilakukan terutama pada penderita diabetes melitus yang menggunakan obat penurun glukosa darah atau insulin. Rumput laut sango-sango atau Gracilaria sp., memiliki potensi sebagai agen antidiabetes. Pengujian aktivitas antihiperglikemik pada model hewan diperlukan sebelum implementasi pada manusia. Penelitian dilakukan dengan pemberian pakan dengan penambahan Gracilaria sp. pada tikus dengan periode yang berbeda. Tikus diberi streptozotocin (50 mg/kg bb) untuk menginduksi diabetes. Hewan dibagi dalam enam kelompok perlakuan: kontrol, kontrol diabetes, tikus diabetes diberi pakan standar dan obat metformin, tikus diabetes diberi Gracilaria sp., selama tiga minggu dan dua minggu, dan tikus normal diberi Gracilaria sp., selama empat minggu. Parameter yang digunakan adalah glukosa darah dan luas area positif ekspresi insulin. Hasil yang didapatkan adalah pemberian streptozotocin mengakibatkan keadaan diabetes pada tikus. Pakan dengan penambahan Gracilaria sp., menunjukkan potensi untuk membantu manajemen hiperglikemik. Hasil yang signifikan ditemukan pada area positif ekspresi insulin. Pemberian pakan dengan penambahan Gracilaria sp., dengan hasil terbaik diperoleh pada pakan dengan pemberian selama tiga minggu.

show abstract

Independent and synergistic activity of the flavonoids of Gracilaria corticata as promising antidiabetic agents

Cited by 9 publications

References 14 publications

Chemical Constituents, Antioxidant Potential, and Antimicrobial Efficacy of Pimpinella anisum Extracts against Multidrug-Resistant Bacteria

Chemical Constituents, Antioxidant Potential, and Antimicrobial Efficacy of Pimpinella anisum Extracts against Multidrug-Resistant Bacteria

Effect of red ginger extract (Zingiber officinale var. Rubrum) of SGOT and SGPT levels in white rats (Rattus norvegicus) induced by Gentamicine

Rumput Laut Sango-sango (Gracilaria sp.) Berpotensi Memperbaiki Kondisi Hiperglikemik dan Ekspresi Insulin Pankreas Tikus Diabetik

Contact Info

Product

Resources

About