Independent and combined effects of hypertension and diabetes on clinical outcomes in patients with COVID‐19: A retrospective cohort study of Huoshen Mountain Hospital and Guanggu Fangcang Shelter Hospital

Sun, Yuhui; Guan, Xizhou; Jia, Lijing; Xing, Ning; Cheng, Liuquan; Liu, Bo; Zhang, Sibing; He, Kunlun

doi:10.1111/jch.14146

Cited by 58 publications

(105 citation statements)

References 31 publications

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“…Sun et al examined 3400 patients and reported similar results to ours [45]. Ruan et al also explored 150 patients with COVID-19 and concluded that cardiovascular disease and hypertension were higher in patients who expired due to the disease, compared to the patients who were discharged (43% vs. 19%; P<0.001) [46].…”

Section: Discussionsupporting

confidence: 57%

Relationship Between Comorbidity, Chronic Diseases, ICU Hospitalization, and Death Rate in the Elderly With Coronavirus Infection

Akhavizadegan

Aghaziarati

Balalemi

et al. 2021

Salmand

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Objectives: The association of comorbidity diseases, such as diabetes and hypertension with the severity of Coronavirus Disease 2019 (COVID-19) has been repeatedly assessed. However, less research has specifically addressed the elderly. This study aimed to describe the demographic and clinical characteristics and evaluate the relationship between comorbidities, and the rates of Intensive Care Unit (ICU) hospitalization and death due to COVID-19 in the elderly. Methods & Materials: This retrospective study was conducted in elderly patients with COVID-19 admitted to Baharloo Hospital. Demographic information, types of underlying diseases, and need for hospitalization in the ICU or death in hospital among the hospitalized patients from March 2020 to July 2020 was extracted from the COVID-19 hospital database. The logistic regression model was used to estimate the Odds Ratio (OR), as a separate measure of the association between the research variables’ outcomes (death & hospitalization outcomes in the ICU). Results: A total of 522 elderly patients were included in the study. Approximately 77% (n=422) of the elderly survived and 23% (n=100) died. The study participants’ mean±SD age was 72.55±8.44 years. besides, and about 54%(n=281) were males. Logistic regression model results suggested that the odds of death in the study participants with ≥2 underlying diseases equaled 1.69 (OR=1.69, 95%CI: 0.97-2.91, P=0.04). Moreover, the odds of ICU hospitalization in them was 2.26 (OR=2.26, 95%CI: 1.34-3.81, P=0.002) time higher than their counterparts who did not have underlying diseases, i.e., statistically significant. Conclusion: Our results are expected to impact preventive interventions and take a more targeted approach to prioritize older patients with risk factors, rather than adopting calendar age policies as a general indicator for risk assessment.

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Section: Discussionsupporting

confidence: 57%

Relationship Between Comorbidity, Chronic Diseases, ICU Hospitalization, and Death Rate in the Elderly With Coronavirus Infection

Akhavizadegan

Aghaziarati

Balalemi

et al. 2021

Salmand

View full text Add to dashboard Cite

show abstract

“…Many studies reported that diabetes mellitus, especially T2DM, is one of the most frequent comorbidities in COVID-19 patients [10,11,[13][14][15]. The ndings also indicated that hyperglycemic state in patients is very important in the prognosis of COVID-19 disease.…”

Section: Discussionmentioning

confidence: 92%

Clinical Outcomes of Non-diabetic COVID-19 Patients with Different Blood Glucose Levels: A Nationwide Turkish Study (TurCoGlycemia)

Haymana

Demirci

Taşçı

et al. 2021

Preprint

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Purpose New coronavirus disease 2019 (COVID-19) has a worse prognosis in patients with diabetes. However, there are insufficient data about the effect of hyperglycemia on COVID-19 prognosis in non-diabetic patients. This study aimed to investigate the relationship between random blood glucose levels measured at the time of diagnosis and prognosis of COVID-19 disease in non-diabetic patients. Methods A nationwide retrospective cohort of non-diabetic patients with conﬁrmed COVID-19 infection from 11 March to 30 May 2020 in the Turkish Ministry of Health database was investigated. The patients were stratified into three groups according to blood glucose levels which were <100 mg/dL in group-1, in the range of 100-139 mg/dl in group-2, and the range of 140-199 mg/dl in group-3. Clinical characteristics and outcomes were compared among the groups. The primary outcome was mortality. Results A total of 12,817 non-diabetic patients (median age [IQR]: 44 [25] years, females: 50.9%) were included. Patients in group-2 (5%) and group-3 (14%) had higher mortality rates than patients in group-1 (2.1%). The rates of hospitalization, hospital stays longer than 8 days, intensive care unit (ICU) admission, ICU stay more than 6 days, and mechanical ventilation were also significantly higher in group-3 patients. Likewise, glucose levels in the range of 140-199 mg/dL were an independent associate of mortality and composite of ICU admission and/or mechanical ventilation. ConclusionHyperglycemia at the time of COVID-19 diagnosis is associated with poor prognosis in non-diabetic patients. Clinicians should be more careful in the treatment of non-diabetic COVID-19 patients with hyperglycemia.

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“…Many studies reported that diabetes mellitus, especially T2DM, is one of the most frequent comorbidities in COVID-19 patients [ 10 , 11 , 13 – 15 ]. The findings also indicated that hyperglycemic state in patients is very important in the prognosis of COVID-19 disease.…”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes of non-diabetic COVID-19 patients with different blood glucose levels: a nationwide Turkish study (TurCoGlycemia)

et al. 2021

View full text Add to dashboard Cite

Purpose New coronavirus disease 2019 (COVID-19) has a worse prognosis in patients with diabetes. However, there are insufficient data about the effect of hyperglycemia on COVID-19 prognosis in non-diabetic patients. This study aimed to investigate the relationship between random blood glucose levels measured at the time of diagnosis and prognosis of COVID-19 disease in non-diabetic patients. Methods A nationwide retrospective cohort of non-diabetic patients with confirmed COVID-19 infection from 11 March to 30 May 2020 in the Turkish Ministry of Health database was investigated. The patients were stratified into three groups according to blood glucose levels which were <100 mg/dL in group-1, in the range of 100–139 mg/dl in group-2, and the range of 140–199 mg/dl in group-3. Clinical characteristics and outcomes were compared among the groups. The primary outcome was mortality. Results A total of 12,817 non-diabetic patients (median age [IQR]: 44 [25] years, females: 50.9%) were included. Patients in group-2 (5%) and group-3 (14%) had higher mortality rates than patients in group-1 (2.1%). The rates of hospitalization, hospital stays longer than 8 days, intensive care unit (ICU) admission, ICU stay more than 6 days, and mechanical ventilation were also significantly higher in group-3 patients. Likewise, glucose levels in the range of 140–199 mg/dL were an independent associate of mortality and composite of ICU admission and/or mechanical ventilation. Conclusion Hyperglycemia at the time of COVID-19 diagnosis is associated with poor prognosis in non-diabetic patients. Clinicians should be more careful in the treatment of non-diabetic COVID-19 patients with hyperglycemia.

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Independent and combined effects of hypertension and diabetes on clinical outcomes in patients with COVID‐19: A retrospective cohort study of Huoshen Mountain Hospital and Guanggu Fangcang Shelter Hospital

Cited by 58 publications

References 31 publications

Relationship Between Comorbidity, Chronic Diseases, ICU Hospitalization, and Death Rate in the Elderly With Coronavirus Infection

Relationship Between Comorbidity, Chronic Diseases, ICU Hospitalization, and Death Rate in the Elderly With Coronavirus Infection

Clinical Outcomes of Non-diabetic COVID-19 Patients with Different Blood Glucose Levels: A Nationwide Turkish Study (TurCoGlycemia)

Clinical outcomes of non-diabetic COVID-19 patients with different blood glucose levels: a nationwide Turkish study (TurCoGlycemia)

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