Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus

Yong, Heng Yaw; Shariff, Zalilah Mohd; Yusof, Barakatun Nisak Mohd; Rejali, Zulida; Tee, Yvonne Yee Siang; Bindels, Jacques; Beek, Eline M. van der

doi:10.1038/s41598-020-65251-2

Cited by 70 publications

(76 citation statements)

References 41 publications

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“…A very recent retrospective cohort study of Malaysian women (SECOST) showed that overweight or obesity and age ≥ 35 years were associated with a 2.45-fold higher risk of GDM [3]. Excessive gestational weight gain during the second trimester by these women further increased their risk of developing GDM [4]. Moreover, other factors such as unhealthy nutritional habits (so-called "western diet" composed, to a large extent, of highly processed and calorie-rich foods, with low amounts of vegetables) and low physical activity are also significant risk factors for developing GDM [5,6].…”

Section: Gestational Diabetes Mellitus-a Brief Description Of Gdm Epimentioning

confidence: 99%

Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences?

2020

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Gestational diabetes mellitus (GDM) is the most common pregnancy complication worldwide and may result in short-term and long-term consequences for offspring. The present review highlights evidence of epigenetic programming, mostly from human studies, which occurs in offspring exposed to maternal GDM during different stages of development, paying special attention to the differences in sensitivity of offspring to maternal hyperglycemia as a result of sex-related factors. We also aim to answer the following question: If these epigenetic changes are constant throughout the lifetime of the offspring, how do they present phenotypically?

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Section: Gestational Diabetes Mellitus-a Brief Description Of Gdm Epimentioning

confidence: 99%

Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences?

2020

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“…Finally, the influence of age and month on GDM and PIH would be discussed. The age might be a notable factor on GDM 23 . Fig.…”

Section: Discussionmentioning

confidence: 99%

Causation between Gestational Diabetes Mellitus(GDM) and Pregnancy Induced Hypertension(PIH): A Statistic Case Study in Harbin, China

Diao¹,

Fang²,

Xiao³

et al. 2021

Preprint

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Both gestational diabetes mellitus(GDM) and pregnancy induced hypertension (PIH) would influence the gestation significantly. However, the causation between these two symptoms remains speculative. 16,404 pregnant women were identified in Harbin, China in this study. We investigated the evaluate the causal effect of GMD on PIH based on the statistic inference theory. The statistical results indicated that GDM might cause PIH. Also, this case study demonstrated that the decrease temperature might also cause hypertension during pregnancy, and the prevalence rate of GDM increased with age. However, the prevalence of diabetes did not show a remarkable difference in varied areas and ages. This study could provide some essential information that will help to investigate the mechanism for GDM and PIH.

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“…More severely overweight or obese women with GDM might have benefited even more from the intervention. Since women with an older maternal age and pregestational overweight/obesity are generally more at risk of GDM [ 18 ], including these in further research is of particular interest.…”

Section: Discussionmentioning

confidence: 99%

No Effect of Lifestyle Intervention during Third Trimester on Brain Programming in Fetuses of Mothers with Gestational Diabetes

et al. 2021

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Maternal metabolism and intrauterine conditions influence development of health and disease in offspring, leading to metabolic, physiologic, and/or epigenetic adaptation of the fetus. Maternal gestational diabetes (GDM) leads to higher incidence of obesity and type 2 diabetes in offspring. We have previously shown that fetuses of insulin-resistant mothers with GDM have a delayed reaction to auditory stimuli in the postprandial state, indicating a fetal central insulin resistance. We tested whether this effect could be influenced by a lifestyle intervention in mothers with GDM, including diet counselling and regular blood glucose measurements. We measured fetal brain activity over the course of a maternal glucose challenge, at two measurement time points (baseline at an average of 29 weeks of gestation and follow-up after 4 weeks) in mothers with GDM and mothers with normal glucose tolerance (NGT). Data from eight mothers were able to be included. Fetuses of GDM mothers showed longer latencies than those of NGT mothers postprandially at both measurement time points during the third trimester and did not show a difference in response patterns between baseline and after 4 weeks. Maternal postprandial blood glucose and insulin values did not change from baseline to follow-up either. While the overall intervention seems to have been effective, it does not appear to have influenced the fetal postprandial brain responses. This might have been because interventions for GDM take place relatively late in pregnancy. Future research should focus on maternal lifestyle interventions as early as possible during gestation, or even prenatally.

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Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus

Cited by 70 publications

References 41 publications

Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences?

Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences?

Causation between Gestational Diabetes Mellitus(GDM) and Pregnancy Induced Hypertension(PIH): A Statistic Case Study in Harbin, China

No Effect of Lifestyle Intervention during Third Trimester on Brain Programming in Fetuses of Mothers with Gestational Diabetes

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