Independence of Capillary Filtration and Tissue Clearance

Hyman, Chester; Rapaport, Samuel I.; Saul, Albert; Morton, M. E.

doi:10.1152/ajplegacy.1952.168.3.674

Cited by 21 publications

(2 citation statements)

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“…Kruh$ffer concluded that diffusion is the dominant mechanism concerned and pointed out the interesting example of p-aminohippuric acid and related substances which pass rapidly out of the peritubular capillaries of the kidney, in the direction opposile to a high rate of 'bulk' flow (peritubular capillary absorption). A similar argument in favor of the diffusion hypothesis has recently been advanced by Hyman et al (67) who have shown that the rates of clearance of Na% and IL31 from human skin are not appreciably affected by concurrent edema formation.…”

Section: Relagve Rates Of Transport Of Yolands By Net Dijusion and By supporting

confidence: 62%

Passage of Molecules Through Capillary Walls

Pappenheimer¹

1953

Physiological Reviews

882

265

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Section: Relagve Rates Of Transport Of Yolands By Net Dijusion and By supporting

confidence: 62%

Passage of Molecules Through Capillary Walls

Pappenheimer¹

1953

Physiological Reviews

882

265

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“…Indeed the concept of nutritive and non‐nutritive flow appears to date from the work of Pappenheimer (1941) who noted that oxygen consumption by the constant pressure perfused dog gastrocnemius muscle was differently controlled by infused adrenaline (stimulatory) or stimulation of vasoconstrictor nerves (inhibitory). Several studies by other workers subsequently showed that maximal aerobic force of muscle and clearance of intramuscularly injected radio‐labelled markers could also be differently affected by agents independent of changes in total blood flow ( Hyman et al . 1952 , Hirvonen & Sonnenschein 1961, Sonnenschein & Hirvonen 1961, Renkin & Rosell 1962).…”

Section: Discussionmentioning

confidence: 99%

Microsphere infusion reverses vasoconstrictor‐mediated change in hindlimb oxygen uptake and energy status

Vincent

Rattigan

Clark

1998

Acta Physiologica Scandinavica

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The vasoconstrictors, angiotensin II (AII) and serotonin (5-HT) produce opposing metabolic effects and appear to control different flow routes in the constant-flow perfused rat hindlimb. In the present study the association between vascular flow route recruitment and metabolism was assessed by selective microsphere embolism of either route. Microspheres (MS, 11.9 +/- 0.1 microns, mean +/- SE diameter) were injected during AII, 5-HT or vehicle infusions (basal conditions) and the effects on hindlimb (4.7 +/- 0.1 g muscle) oxygen uptake (VO2) and indices of energy status CrP/Cr, CrP/ATP and energy charge (EC) of the calf muscle group assessed. MS (1.5 x 10(6)) injected during vehicle, or 5-HT infusion increased VO2 (P < 0.05) but did not affect energy status. During AII, MS decreased VO2. Change in VO2 correlated positively with CrP/Cr (r = 0.68, P < 0.0001) and CrP/ATP (r = 0.51, P < 0.001) but not EC (r = 0.08, P = 0.59). MS (1.5 x 10(6)) increased pressure but did not affect the flow rate. The metabolic changes resulting from 1.5 x 10(6) microspheres were intensified by a second injection of 1.5 x 10(6) microspheres but further injection (> 3.0 x 10(6) microspheres) began to inhibit flow. It is concluded that a finite number (< or = 3.0 x 10(6)) of microspheres of 11.9 microns diameter has opposite effects on VO2 depending on the vasoconstrictor present and that these effects result from the occlusion of the different vascular route accessed by each vasoconstrictor. The data support the proposal that hindlimb metabolism can be controlled by vasoconstrictors as a result of selective vascular recruitment.

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