“…Predicting and controlling the regioselectivity of these reactions has been challenging, however, especially with internal alkynes. Previous synthetic reactions have focused on electronically polarized alkynes, such as alkynones and alkynoates (Scheme a), sterically hindered alkynes, including those with silyl substituents (Scheme b) ,, and alkynes with coordinating directing groups, such as pyridine-containing substrates (Scheme c). ,, …”