Indenoindole depresses lipofuscin formation in cultured neonatal rat myocardial cells

Marzabadi, Massoud R.; Jones, Charles B.; Rydström, Jan

doi:10.1016/0047-6374(94)01569-8

Cited by 8 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, antioxidants inhibit lipofuscin formation of which requires the presence of O 2 (326). It appears as if Amadori products themselves are a source formation in cultured cardiomyocytes, whereas lysosomal protease inhibitors increase it (199,201,202).…”

Section: Refinements and Corollaries Of The Free Radical Theory mentioning

confidence: 99%

The Free Radical Theory of Aging Matures

Beckman

Ames

1998

Physiological Reviews

3,367

2,200

View full text Add to dashboard Cite

The free radical theory of aging, conceived in 1956, has turned 40 and is rapidly attracting the interest of the mainstream of biological research. From its origins in radiation biology, through a decade or so of dormancy and two decades of steady phenomenological research, it has attracted an increasing number of scientists from an expanding circle of fields. During the past decade, several lines of evidence have convinced a number of scientists that oxidants play an important role in aging. (For the sake of simplicity, we use the term oxidant to refer to all "reactive oxygen species," including O2-., H2O2, and .OH, even though the former often acts as a reductant and produces oxidants indirectly.) The pace and scope of research in the last few years have been particularly impressive and diverse. The only disadvantage of the current intellectual ferment is the difficulty in digesting the literature. Therefore, we have systematically reviewed the status of the free radical theory, by categorizing the literature in terms of the various types of experiments that have been performed. These include phenomenological measurements of age-associated oxidative stress, interspecies comparisons, dietary restriction, the manipulation of metabolic activity and oxygen tension, treatment with dietary and pharmacological antioxidants, in vitro senescence, classical and population genetics, molecular genetics, transgenic organisms, the study of human diseases of aging, epidemiological studies, and the ongoing elucidation of the role of active oxygen in biology.

show abstract

Section: Refinements and Corollaries Of The Free Radical Theory mentioning

confidence: 99%

The Free Radical Theory of Aging Matures

Beckman

Ames

1998

Physiological Reviews

3,367

2,200

View full text Add to dashboard Cite

show abstract

“…Natural and synthetic indoles proved to be able to protect various tissues against oxidative stress, predominantly by scavenging deleterious reactive oxygen species. − A pulse-radiolysis study showed that the molecular mechanism of radical scavenging of the synthetic hexahydropyridoindole antioxidant stobadine ( 1 ) resided in the deprotonation of the indoline nitrogen of its oxidized form ( 1a ), to give a resonance-stabilized, nitrogen-centered radical ( 1b ) (Scheme ) 1 One-Electron Oxidation of Stobadine ( 1 ) Followed by Deprotonation of the Indole Nitrogen of Its Oxidized Form 1 a To Give a Resonance-Stabilized, Nitrogen-Centered Radical ( 1b ) …”

Section: Introductionmentioning

confidence: 99%

Free Radical Scavenging and Antioxidant Activities of Substituted Hexahydropyridoindoles. Quantitative Structure−Activity Relationships

et al. 2006

View full text Add to dashboard Cite

New synthetic substituted hexahydropyridoindoles were studied for their radical scavenging ability in a system of an ethanolic solution of alpha,alpha'-diphenyl-beta-picrylhydrazyl and for their lipid peroxidation inhibitory properties in a suspension of unilamellar dioleoylphosphatidylcholine liposomes. The activities in both in vitro systems were correlated with several structural parameters. In the homogeneous system of alpha,alpha'-diphenyl-beta-picrylhydrazyl, the sum of aromatic substitution constants (sigma(+)) and the hydration energy were shown to be effective predictors of the radical scavenging activity of the hexahydropyridoindole derivatives. Moreover, in the heterogeneous system comprising a model liposomal membrane, the overall antioxidant activity of the compounds was affected by their lipid-phase availability governed by the lipophilicity and basicity of the molecules.

show abstract

“…1 [I]), proved able to protect various tissues against oxidative stress, predominantly by scavenging deleterious reactive oxygen species. [14][15][16][17][18][19][20][21][22][23][24] Pulse-Stobadine and its two structural analogues, dehydrostobadine and N-acetylated stobadine were used to examine how structural alteration in the close proximity of the indolic nitrogen would influence the antioxidant activity of the substituted pyridoindoles. The compounds were tested for their efficiency to scavenge stable free radicals of a,a¢-diphenyl-b-picrylhydrazyl as well as for their ability to prevent 2,2¢-azobis-(2-amidinopropane)hydrochloride induced peroxidation of dioleoyl phosphatidylcholine liposomes.…”

Section: Introductionmentioning

confidence: 99%

Structural aspects of antioxidant activity of substituted pyridoindoles

Račková

Štefek²,

Májeková³

2002

Redox Report

View full text Add to dashboard Cite

Stobadine and its two structural analogues, dehydrostobadine and N-acetylated stobadine were used to examine how structural alteration in the close proximity of the indolic nitrogen would influence the antioxidant activity of the substituted pyridoindoles. The compounds were tested for their efficiency to scavenge stable free radicals of alpha,alpha'-diphenyl-beta-picrylhydrazyl as well as for their ability to prevent 2,2'-azobis-(2-amidinopropane)hydrochloride induced peroxidation of dioleoyl phosphatidylcholine liposomes. The results proved that the substituted pyridoindoles can act as potent scavengers of peroxyl radicals both in aqueous and lipid phases, the antioxidant activity being comparable with that of Trolox. Structural changes in the proximity of the indolic nitrogen were found crucial for the radical scavenging efficiency: aromatisation of the pyridoindole skeleton in dehydrostobadine lowered the antioxidant activity, while acetylation of the indolic nitrogen completely abolished the ability to scavenge peroxyl radicals. The results are in agreement with the notion that the antioxidant activity of stobadine and of the related pyridoindoles may be mediated via the indolic nitrogen centre. When stobadine and Trolox were present simultaneously in liposomal incubations, Trolox spared stobadine in a dose-dependent manner; a direct interaction of Trolox with stobadinyl radical appears to be a plausible explanation with possible consequences for the antioxidant capacity of stobadine under in vivo conditions, where re-cycling of stobadine by vitamin E might occur.

show abstract

Indenoindole depresses lipofuscin formation in cultured neonatal rat myocardial cells

Cited by 8 publications

References 27 publications

The Free Radical Theory of Aging Matures

The Free Radical Theory of Aging Matures

Free Radical Scavenging and Antioxidant Activities of Substituted Hexahydropyridoindoles. Quantitative Structure−Activity Relationships

Structural aspects of antioxidant activity of substituted pyridoindoles

Contact Info

Product

Resources

About