Indapamide regresses, but transdermal clonidine does not regress, left ventricular hypertrophy in hypertensive diabetic patients

Tan, Stanley A.; Berk, Lee; Tan, Linda G.

doi:10.1016/s0002-9149(97)89235-1

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…Доказа тельства кардиопротективного эффекта индапамида получены в мультицентровом исследовании LIVE (Left ventricular hypertrophy regression, Indapamide Versus Enalapril), показавшем, что терапия индапамидом MB в дозе 1,5 мг/сут эффективно уменьшает выра женность ГЛЖ у больных АГ [30]. Способность индапамида уменьшать ГЛЖ показана и у больных СД [73].…”

Section: прогностическая значимость глжunclassified

Gipertrofiya levogo zheludochka u bol'nykh sakharnym diabetom: faktory riska i podkhody k korrektsii

Бондарь¹,

Klimentov²

2004

Diabetes mellitus

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Section: прогностическая значимость глжunclassified

Gipertrofiya levogo zheludochka u bol'nykh sakharnym diabetom: faktory riska i podkhody k korrektsii

Бондарь¹,

Klimentov²

2004

Diabetes mellitus

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Diuretics

McInnes¹

1997

Side Effects of Drugs Annual

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Clinical trials of single-drug therapy for the cardiac effects of hypertension

Gottdiener

1999

American Journal of Hypertension

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Much has been learned in epidemiologic studies and clinical trials about the relationships between hypertension and cardiac anatomic and functional responses, as well as the effects of antihypertensive treatment on those responses. The results of recent multicenter trials have supported initial concerns that not all drugs effective for blood pressure reduction are effective for reduction of LV mass and regression of LVH. However, recent trials of single-drug therapy suggest that those agents initially believed to be ineffective for LV mass reduction (principally diuretics and beta-blockers), on the basis of pathophysiologic theory and inadequate clinical trials, may in fact be quite effective for LVH regression, as well as for improving cardiac outcomes. Additionally, fears concerning the adverse effects of LV mass reduction on systolic and diastolic LV function have not been justified by the results of clinical trials. In conclusion, the often-assumed lack of efficacy of diuretics and beta-blockers for the reduction of LV mass can no longer be used as a reason to disregard the longstanding recommendations of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of Hypertension supporting the use of diuretics and beta-blockers as the initial drug treatment of hypertension.

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Indapamide regresses, but transdermal clonidine does not regress, left ventricular hypertrophy in hypertensive diabetic patients

Cited by 4 publications

References 24 publications

Gipertrofiya levogo zheludochka u bol'nykh sakharnym diabetom: faktory riska i podkhody k korrektsii

Gipertrofiya levogo zheludochka u bol'nykh sakharnym diabetom: faktory riska i podkhody k korrektsii

Diuretics

Clinical trials of single-drug therapy for the cardiac effects of hypertension

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