Indapamide Reduces Hypertensive Left Ventricular Hypertrophy

Thiazide diuretics are widely used for the management of hypertension. In recent years, it has been actively debated that there is interchangeability of thiazide‐type diuretics hydrochlorothiazide and thiazide‐like diuretics including indapamide and chlorthalidone for the treatment of hypertension. With the purpose of seeking out the best thiazide diuretic for clinicians, we summarized the existing evidence on the two types of drugs and conducted a meta‐analysis on their efficacy in lowering blood pressure and effects on blood electrolyte, glucose and total cholesterol. Twelve trials were identified: five based on the comparison of indapamide versus hydrochlorothiazide and seven based on the chlorthalidone versus hydrochlorothiazide. In the meta‐analysis of blood pressure reduction, thiazide‐like diuretics seemed to further reduce systolic BP ([95% CI]; −5.59 [−5.69, −5.49]; P < 0.001) and diastolic BP ([95% CI]; −1.98 [−3.29, −0.66]; P = 0.003). Meanwhile, in the analysis of side effects, the incidence of hypokalemia ([95% CI]; 1.58 [0.80, 3.12]; P = 0.19), hyponatremia ([95% CI]; −0.14 [−0.57, 0.30], P = 0.54), change of blood glucose ([95% CI];0.13 [−0.16, 0.41], P = 0.39) and total cholesterol ([95% CI]; 0.13 [−0.16, 0.41], P = 0.39) showed that there is no statistical significant differences between the two groups of drugs. In conclusion, using thiazide‐like diuretics is superior to thiazide‐type diuretics in reducing blood pressure without increasing the incidence of hypokalemia, hyponatraemia and any change of blood glucose and serum total cholesterol.

show abstract

“…The characteristics of studies used for the meta‐analysis were shown in Table . These studies were published from 1983 to 2016.…”

Section: Methodsmentioning

confidence: 99%

Comparison of thiazide‐like diuretics versus thiazide‐type diuretics: a meta‐analysis

Liang

Cao

et al. 2017

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Индапамид является тиазидоподобным сульфонамидным диуретиком, специально разработанным для лечения АГ. Его антигипертензивная эффективность была доказана в большом числе РКИ как по сравнению с плацебо, так и другими АГП [51][52][53][54]. Индапамид в отличие от других диуретиков, метаболически нейтрален и не оказывает отрицательного влияния на липидный [55] и углеводный обмен [56].…”

Section: место индапамида у пациентов с агunclassified

Modern antihypertensive therapy: the effectiveness of a unique Russian fixed-dose combination of ramipril and indapamide

Конради

Nedogoda²,

Недошивин³

et al. 2020

Russ J Cardiol

View full text Add to dashboard Cite

show abstract

“…Two “thiazide‐like” drugs deserve mention. The indole derivative indapamide may be used in individuals intolerant of thiazides; mechanistically, it appears to block the L ‐calcium channel in a fashion similar to that of CCBs 11 and has been reported to be more effective than 25 mg of hydrochlorothiazide in regressing left ventricular hypertrophy 18 . Metolazone appears to be effective even in the presence of reduced renal function 19 ; however, outcome data are lacking for this drug.…”

Section: Diuretics: All Are Not the Samementioning

confidence: 99%

Beyond the Usual Strategies for Blood Pressure Reduction: Therapeutic Considerations and Combination Therapies

Giles

Sander

2001

J of Clinical Hypertension

View full text Add to dashboard Cite

Rapidly accumulating clinical data have repeatedly demonstrated not only the critical importance of even small increases in blood pressure as a pathophysiologic factor in the development of cardiovascular disease, particularly in individuals with diabetes mellitus, but also the therapeutic necessity of more aggressive blood pressure reduction and the achievement of progressively lower blood pressure targets in reducing cardiovascular event rates. JNC VI has defined optimal blood pressure as ≤120/80 mm Hg, and Stage 1 hypertension as ≥140/80 mm Hg. Target blood pressures are now ≤130/80 mm Hg in patients with diabetes and <125/75 mm Hg for patients with hypertensive renal disease with proteinuria of>1 gm/24 hours. Achieving such target pressures is increasingly difficult, particularly in diabetic patients with chronic renal disease, who require complex multidrug antihypertensive regimens. This review attempts to provide some suggestions for constructing such antihypertensive regimens, and provides considerations for the appropriate use of diuretics and the most effective drug combinations. Factors potentially contributing to drug resistant hypertension include such problems as failure to maximize drug dosing, suboptimal diuretic use, noncompliance, and possible confounding effects of such concomitant medications as nonsteroidal and anti‐inflammatory drugs or decongestants. The issues underlying drug‐resistant hypertension are listed, together with strategies for overcoming this problem.

show abstract

Indapamide Reduces Hypertensive Left Ventricular Hypertrophy

Cited by 29 publications

References 0 publications

Comparison of thiazide‐like diuretics versus thiazide‐type diuretics: a meta‐analysis

Comparison of thiazide‐like diuretics versus thiazide‐type diuretics: a meta‐analysis

Modern antihypertensive therapy: the effectiveness of a unique Russian fixed-dose combination of ramipril and indapamide

Beyond the Usual Strategies for Blood Pressure Reduction: Therapeutic Considerations and Combination Therapies

Contact Info

Product

Resources

About