Incubation Period of Shiga Toxin–Producing <i>Escherichia coli</i>

Awofisayo-Okuyelu, Adedoyin; Brainard, Julii; Hall, Ian; McCarthy, Noel D.

doi:10.1093/epirev/mxz001

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…The mean incubation period of STEC ranges from 3.5 to 8.1 days [ 22 ]. The typical clinical presentation of STEC-HUS is watery diarrhea, which, 3–5 days later, progresses to bloody diarrhea and severe abdominal pain with nausea and vomiting, followed by thrombocytopenia and AKI 2–14 days after the onset of diarrhea [ 23 ].…”

Section: Stec-hus Diagnosismentioning

confidence: 99%

Diagnosis and Treatment for Shiga Toxin-Producing Escherichia coli Associated Hemolytic Uremic Syndrome

Liu

Thaker

Wang

et al. 2022

Toxins

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Shiga toxin-producing Escherichia coli (STEC)-associated hemolytic uremic syndrome (STEC-HUS) is a clinical syndrome involving hemolytic anemia (with fragmented red blood cells), low levels of platelets in the blood (thrombocytopenia), and acute kidney injury (AKI). It is the major infectious cause of AKI in children. In severe cases, neurological complications and even death may occur. Treating STEC-HUS is challenging, as patients often already have organ injuries when they seek medical treatment. Early diagnosis is of great significance for improving prognosis and reducing mortality and sequelae. In this review, we first briefly summarize the diagnostics for STEC-HUS, including history taking, clinical manifestations, fecal and serological detection methods for STEC, and complement activation monitoring. We also summarize preventive and therapeutic strategies for STEC-HUS, such as vaccines, volume expansion, renal replacement therapy (RRT), antibiotics, plasma exchange, antibodies and inhibitors that interfere with receptor binding, and the intracellular trafficking of the Shiga toxin.

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Section: Stec-hus Diagnosismentioning

confidence: 99%

Diagnosis and Treatment for Shiga Toxin-Producing Escherichia coli Associated Hemolytic Uremic Syndrome

Liu

Thaker

Wang

et al. 2022

Toxins

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“…There are many STEC serogroups that are capable of causing human disease, with the O157 serogroup the most common. Transmission occurs via consumption of contaminated foods, the fecal-oral route, or cross-contamination, with an incubation period ranging from 3.5 to 8.1 days [ 30 ]. STEC causes approximately 3 million cases and 200 deaths annually [ 31 ].…”

Section: Toxins Produced By Frequently Isolated Bacteriamentioning

confidence: 99%

Clinically Important Toxins in Bacterial Infection: Utility of Laboratory Detection

Forbes

2020

Clinical Microbiology Newsletter

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The elaboration of proteins that damage host cells is fundamental to the pathogenesis of many bacterial pathogens. The clinical significance of many bacterial toxins is well recognized, and routine detection is necessary to confirm definitive diagnosis for some types of infectious diseases. Determining the clinical significance of a toxin involves many factors, including the toxin's prevalence, virulence, and role in disease pathogenesis. While essential from a diagnostic perspective, toxin detection has the potential to be important for patient management decision making, as well as infection prevention and control measures. This review focuses on the history, epidemiology, pathogenesis, clinical presentation, and management of infections associated with well-defined, clinically important toxins (such as Shiga toxin-producing Escherichia coli ), as well as those that are less well defined (such as Staphylococcus aureus' Panton-Valentine leukocidin) where detection may yield clinically important information.

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