Incretins, amylin and other gut‐brain axis hormones in children with coeliac disease

Papastamataki, Maria; Papassotiriou, Ioannis; Bartzeliotou, Αnastasia; Vazeou, Andriani; Roma, Elefthería; Chrousos, George P.; Kanaka‐Gantenbein, Christina

doi:10.1111/eci.12193

Cited by 12 publications

(16 citation statements)

References 55 publications

(105 reference statements)

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“…Celiac disease is associated with changes in eec number 171,172 as well as peptide granule storage. 130 Serum levels of GLP-1, GIP 173 and plasma CCK, thought to be responsible for the pancreatic dysfunction seen in celiac patients, 174 are seen to be reduced in celiac blood. However, increases in CgA þ cells are also observed, 174 with increased ghrelin þ cells seen in the duodenum that correlate with inflammation.…”

Section: Non-infectious Enteropathiesmentioning

confidence: 99%

Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity

2018

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The intestinal epithelium must balance efficient absorption of nutrients with partitioning commensals and pathogens from the bodies' largest immune system. If this crucial barrier fails, inappropriate immune responses can result in inflammatory bowel disease or chronic infection. Enteroendocrine cells represent 1% of this epithelium and have classically been studied for their detection of nutrients and release of peptide hormones to mediate digestion. Intriguingly, enteroendocrine cells are the key sensors of microbial metabolites, can release cytokines in response to pathogen associated molecules and peptide hormone receptors are expressed on numerous intestinal immune cells; thus enteroendocrine cells are uniquely equipped to be crucial and novel orchestrators of intestinal inflammation. In this review, we introduce enteroendocrine chemosensory roles, summarize studies correlating enteroendocrine perturbations with intestinal inflammation and describe the mechanistic interactions by which enteroendocrine and mucosal immune cells interact during disease; highlighting this immunoendocrine axis as a key aspect of innate immunity.

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Section: Non-infectious Enteropathiesmentioning

confidence: 99%

Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity

2018

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“…A recent study revealed children with CD have a secretion pattern of gut-brain axis hormones that differs from that of controls. Alterations in this axis were more pronounced in children with both CD and type I diabetes mellitus; nevertheless, the roles of these gut-brain axis hormones in food intake and glycemic control in patients with CD and type I diabetes mellitus must be clarified [75]. …”

Section: Pathogenetic Link Between CD and Overweight/obesitymentioning

confidence: 99%

Celiac Disease and Overweight in Children: An Update

et al. 2014

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The clinical presentation of celiac disease in children is very variable and differs with age. The prevalence of atypical presentations of celiac disease has increased over the past 2 decades. Several studies in adults and children with celiac disease indicate that obesity/overweight at disease onset is not unusual. In addition, there is a trend towards the development of overweight/obesity in celiac patients who strictly comply with a gluten-free diet. However, the pathogenesis and clinical implications of the coexistence of classic malabsorption (e.g., celiac disease) and overweight/obesity remain unclear. This review investigated the causes and main clinical factors associated with overweight/obesity at the diagnosis of celiac disease and clarified whether gluten withdrawal affects the current trends of the nutritional status of celiac disease patients.

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“…10 A differential secretion pattern of brain-gut axis hormones has also been described in patients with both untreated and treated CeD that may underlie weight gain and development of the metabolic syndrome. 10,11 In the background of obesity and metabolic syndrome, many patients develop nonalcoholic fatty liver disease (NAFLD). Fatty liver, if untreated, can lead to cirrhosis in up to 3% patients.…”

Section: Introductionmentioning

confidence: 99%

Patients with celiac disease are at high risk of developing metabolic syndrome and fatty liver

et al. 2021

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studies have made similar observations and up to 44% of the patients were found to be overweight or obese at the time of diagnosis of CeD. 2,3 Furthermore, many studies have uniformly shown that underweight patients at the time of diagnosis tend to gain weight on gluten-free diet (GFD). 4-6 Contradictory to that while 22% to 82% of overweight and obese patients gain weight on a GFD; 4,7 some of the overweight and obese patients with CeD lose weight on GFD. 6,8 As described above, many studies have looked into the effect of a GFD on BMI but the association between CeD and metabolic syndrome has not been explored in much detail. In a recent prospective study, Tortora et al. 9 reported an increase in the prevalence of metabolic syndrome from 2% at the time of diagnosis to 30% after 12 months of GFD. Although there is emerging evidence that a sizeable proportion of patients with CeD gain weight

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Incretins, amylin and other gut‐brain axis hormones in children with coeliac disease

Abstract: Our study revealed a different secretion pattern of gut-brain axis hormones in children with CD compared with HC. The alterations in the axis were more pronounced in children with both CD and T1DM.

Cited by 12 publications

References 55 publications

Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity

Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity

Celiac Disease and Overweight in Children: An Update

Patients with celiac disease are at high risk of developing metabolic syndrome and fatty liver

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