Incremento en las concentraciones de ligando CD40 soluble plaquetario en pacientes con síndrome antifosfolipídico primario

Lopez, A.; Ortega, Lourdes Olguín; Saavedra, Miguel Ángel; Cruz, Raymundo; Flores, Rafael; Peña, Maximiliano García de la

doi:10.1016/j.reuma.2012.10.018

Cited by 2 publications

(1 citation statement)

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“…Platelets are the major source of sCD40L in the circulation [ 65 , 97 , 98 ]. The normal range of sCD40L in the serum of a healthy adult is estimated at 0.79 to 4.7 ng/mL, by means of immunoassay techniques [ 99 , 100 , 101 ].…”

Section: Platelet Cd40lmentioning

confidence: 99%

The Signaling Role of CD40 Ligand in Platelet Biology and in Platelet Component Transfusion

Aloui

Prigent

Sut

et al. 2014

IJMS

141

116

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The CD40 ligand (CD40L) is a transmembrane molecule of crucial interest in cell signaling in innate and adaptive immunity. It is expressed by a variety of cells, but mainly by activated T-lymphocytes and platelets. CD40L may be cleaved into a soluble form (sCD40L) that has a cytokine-like activity. Both forms bind to several receptors, including CD40. This interaction is necessary for the antigen specific immune response. Furthermore, CD40L and sCD40L are involved in inflammation and a panoply of immune related and vascular pathologies. Soluble CD40L is primarily produced by platelets after activation, degranulation and cleavage, which may present a problem for transfusion. Soluble CD40L is involved in adverse transfusion events including transfusion related acute lung injury (TRALI). Although platelet storage designed for transfusion occurs in sterile conditions, platelets are activated and release sCD40L without known agonists. Recently, proteomic studies identified signaling pathways activated in platelet concentrates. Soluble CD40L is a good candidate for platelet activation in an auto-amplification loop. In this review, we describe the immunomodulatory role of CD40L in physiological and pathological conditions. We will focus on the main signaling pathways activated by CD40L after binding to its different receptors.

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