Incremental net monetary benefit of direct oral anticoagulants for the prevention of venous thromboembolism after total knee or hip replacement: A systematic review and meta-analysis

Veettil, Sajesh K.; Harris, Jordi; Syeed, M Sakil; Thakkinstian, Ammarin; Chaikledkaew, Usa; Witt, Daniel M.; Chaiyakunapruk, Nathorn

doi:10.1016/j.thromres.2022.06.004

Cited by 3 publications

(3 citation statements)

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“…Each INB and its variance were calculated per the approaches described previously [41,45,46,51,52] (a detailed description is provided in Appendix S3). If a study presented results of more than one comparison (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Each item was graded as yes, partly, unclear, no or not applicable. Three important items that are relevant to the overall validity assessment and the study context included limited sensitivity analysis bias, wrong model bias and bias related to treatment effects [45][46][47]. If the answers to all three items were yes, the studies were classified as having a low risk of bias.…”

Section: Data Extraction and Risk Of Bias Assessmentmentioning

confidence: 99%

“…Data were prepared according to five scenarios (described in Appendices S3 and S4) [46][47][48]. All data reported in cost were converted to United States dollars (USD) in 2021 using the consumer price index (CPI) [49] and purchasing power parity (PPP) conversion [50].…”

Section: Data Preparationmentioning

confidence: 99%

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Incremental net monetary benefit of using varenicline for smoking cessation: A systematic review and meta‐analysis of economic evaluation studies

Chaisai,

Patikorn,

Thavorn

et al. 2024

Addiction

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AimsTo conduct a systematic review and meta‐analysis and pool the incremental net benefits (INBs) of varenicline compared with behaviour support with bupropion or nicotine replacement therapy (NRT), behaviour support alone and unaided cessation in adult smokers making a first‐time attempt to quit.MethodsA search for economic evaluation studies was conducted from inception to 30 September 2022, on PubMed, Embase, Cost‐Effectiveness Analysis (CEA) Registry by Tufts Medical Centre, EconLit and the NHS Economic Evaluation Database (NHS EED). Eligible studies were included if they were (1) conducted among adults ages 18 years old and older who were smokers attempting to quit for the first time; (2) compared varenicline to behaviour support with bupropion or NRT, behaviour support alone and unaided cessation; and (3) performed a CEA or cost‐utility analysis. The INBs were calculated and pooled across studies stratified by country income level and study perspective using the random‐effects model. Statistical heterogeneity between studies was assessed using the I2 statistic and Cochrane Q statistic.ResultsOf the 1433 identified studies, 18 studies were included in our review. Our findings from healthcare system/payer perspective suggested that the use of varenicline is statistically significantly cost‐effective compared with bupropion (pooled INB, $830.75 [95% confidence interval, $208.23, $1453.28]), NRTs ($636.16 [$192.48, $1079.84]) and unaided cessation ($4212.35 [$1755.79, $6668.92]) in high‐income countries. Similarly, varenicline is also found to be cost‐effective compared to bupropion ($2706.27 [$1284.44, $4128.11]), NRTs ($3310.01 [$1781.53, $4838.50]) and behavioural support alone ($5438.22 [$4105.99, $6770.46]) in low‐ and middle‐income countries.ConclusionVarenicline is cost‐effective as a smoking cessation aid when compared with behavioural support with bupropion or nicotine replacement therapies and behavioural support alone in both high‐income countries and low‐ and middle‐income countries, from the healthcare system/payer perspective in adult smokers who attempt to quit for the first time.

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