“…[13][14][15][16][17][18][19][20] Intensity 8,10,[13][14][15][16]19 and texture [9][10][11]16,18 features were commonly used to characterize suspicious lesions. Texture features included first-order statistics, 9,16 co-occurrence matrix, 10,16 gradient operators, 16,18 local binary pattern, 18 local phase quantization, 9 and wavelet transform. 11 In addition, graph embedding, 12,21 random walk, 17 locally linear embedding, 15 and principal component analysis 11 were used to reduce data dimension and/or to improve data representation.…”