Increasing trend of &lt;i&gt;Helicobacter pylori&lt;/i&gt;-uninfected gastric cancer without gastric atrophy

Nishizawa, Toshihiro; Yoshida, Shuntaro; Toyoshima, Akira; Matsuno, Tatsuya; Sakitani, Kosuke; Kato, Jun; Ebinuma, Hirotoshi; Fujishiro, Mitsuhiro; Suzuki, Hidekazu; Toyoshima, Osamu

doi:10.3164/jcbn.22-56

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…The prevalence of H. pylori infection has decreased over the past decades due to improvements in the sanitary environment and the widespread eradication of H. pylori in Japan. The incidence of HPNGC without gastric atrophy has been reported to increase over time 36 . Although the risk factors for HPNGC remain unclear, we found that smoking and aging are independent risk factors for HPNGC.…”

Section: Discussionmentioning

confidence: 49%

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Impact of metabolic dysfunction‐associated fatty liver disease on the incidence of Helicobacter pylori‐negative gastric cancer

Nakane,

Fukunaga,

Nakano

et al. 2024

Hepatology Research

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AimThe incidence of Helicobacter pylori‐negative gastric cancer (HPNGC) is increasing worldwide. Recently, metabolic dysfunction‐associated fatty liver disease (MAFLD) has been reported to be associated with various cancers, but its association with HPNGC has not been reported. We aimed to identify important independent factors associated with HPNGC, including MAFLD.MethodsThis multicenter observational cohort study enrolled patients with gastric cancer (n=1,078) and health checkup examinees (n=17,408). We analyzed patients with HPNGC (n=26) and healthy participants with no Helicobacter pylori infection or any abnormal findings on upper gastrointestinal endoscopy (n=1,130). A logistic regression model was used to identify independent factors associated with HPNGC. The priority of the factors associated with HPNGC was evaluated using a decision tree algorithm and random forest analysis.ResultsAmong all patients with gastric cancer, 2.4% (26/1,078) were diagnosed with HPNGC (mean age, 64 years; male/female, 13/13). In the logistic regression analysis, age, smoking, and MAFLD (odds ratio, 6.5359; 95% confidence interval, 2.5451–16.7841; p<0.0001) were identified as independent factors associated with HPNGC. MAFLD was also identified as the most important classifier for the presence of HPNGC in decision tree analyses. HPNGC was observed in 5.2% of patients with MAFLD and 0.8% of patients without MAFLD. In the random forest analysis of the HPNGC, MAFLD was identified as the distinguishing factor with the highest variable importance (0.32).ConclusionsMAFLD was the most influential independent factor associated with HPNGC. These findings suggest that fatty liver and metabolic dysfunction may be involved in the pathogenesis of HPNGC.This article is protected by copyright. All rights reserved.

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Section: Discussionmentioning

confidence: 49%

“…The incidence of HPNGC without gastric atrophy has been reported to increase over time. 36 Although the risk factors for HPNGC remain unclear, we found that smoking and aging are independent risk factors for HPNGC. In addition, we found, for the first time, that MAFLD was an independent risk factor for HPNGC.…”

Section: Discussionmentioning

confidence: 73%

Impact of metabolic dysfunction‐associated fatty liver disease on the incidence of Helicobacter pylori‐negative gastric cancer

Nakane,

Fukunaga,

Nakano

et al. 2024

Hepatology Research

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Intragastric bacterial infection and endoscopic findings in <i>Helicobacter pylori</i>-negative patients

Kawai,

Akimito

et al. 2024

J. Clin. Biochem. Nutr.

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In the present study, the authors examined the association between gastric bacterial infection and gastric endoscopic findings in H. pylori-negative patients. The subjects were 105 H. pylori-negative patients. The mean age was 72.8 ± 9.1 years. Endoscopy and gastric juice culture were performed. The presence or absence of endoscopic findings was checked according to the Kyoto classification of gastritis. Results: Culture was positive in 69 patients (65.7%), with Streptococcus α-hemolytic being the most common (51 patients), followed by Neisseria sp. (43 patients). According to the univariate analysis, there was a significant difference between the results of culture and background factors in the use of gastric antisecretory drugs and between the results of culture and various endoscopic findings in atrophic gastritis, intestinal metaplasia, RAC, mucosal swelling, sticky mucus, hyperplastic polyps, hematin, and gastric cobblestone-like lesions. Furthermore, multivariate analysis revealed significant differences in background factors such as the use of gastric antisecretory drugs and endoscopic findings only in patients with mucosal swelling. Endoscopic findings of non-H. pylori bacteria-positive gastritis differed from endoscopic findings of H. pylori-infected gastritis in several respects. Conclusion: Our results suggest that non-H. pylori bacteria may infect the stomach and cause gastric inflammation, especially in patients who use gastric antisecretory drugs.

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Increasing trend of <i>Helicobacter pylori</i>-uninfected gastric cancer without gastric atrophy

Cited by 2 publications

References 26 publications

Impact of metabolic dysfunction‐associated fatty liver disease on the incidence of Helicobacter pylori‐negative gastric cancer

Impact of metabolic dysfunction‐associated fatty liver disease on the incidence of Helicobacter pylori‐negative gastric cancer

Intragastric bacterial infection and endoscopic findings in <i>Helicobacter pylori</i>-negative patients

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