Increasing trend of acute hepatitis A in north India: Need for identification of high‐risk population for vaccination

Hussain, Zahid; Das, Bhudev C.; Husain, Syed Akhtar; Murthy, N S; Kar, Premashis

doi:10.1111/j.1440-1746.2006.04232.x

Cited by 41 publications

(67 citation statements)

References 33 publications

(29 reference statements)

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“…In contrary other studies showed prevalence of Kaur et al (2002) 4 HCV in adults (3.4%), in children (3.1%), Poddar et al (2002) 5 has showed a prevalence of HCV (1.16%) in children, Hussain Z et al (2006) 6 has showed a prevalence of HCV (2.02%) in adults, kumar s et al (2007) 7 showed a prevalence of HCV (2.8%) in adults. These studies indicate the prevalence of HCV is increasing in both adults and children in the present years.…”

Section: Discussionmentioning

confidence: 54%

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Prevalence of Different Viral Markers in Patients of Acute Viral Hepatitis in and Around Visakhapatnam : Hospital Based Study

B¹,

M²,

Raju³

et al. 2015

jemds

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Acute viral hepatitis (AVH) is a major public health problem and is an important cause of morbidity and mortality in the developing countries. AIM: The aim of the present study is to study the serological profile of acute viral hepatitis in children and adults admitted in King George Hospital, Visakhapatnam and also age and sex distribution of patients suffering from acute viral hepatitis and also comparing the etiological profile by studying serological markers of common viral agents. SUBJECTS AND METHODS: Samples were collected from 80 individuals with jaundice and other clinical and biochemical evidences of acute viral hepatitis. They were tested for hepatitis surface antigen, HBcIgM, HAVIgM, HEVIgM, Antibodies to HCV by the enzyme-linked immuno sorbent assay. RESULTS: Out of the 80 viral hepatitis cases (47 adults+33 children). In adults 20(42.5%) patients presented HBV (26.96%) was identified as the most common cause of acute hepatitis followed by HEV14 (29.8%), HEV+HAV4 (8.5%) and HAV 6(12.76%). Co-infections with more than one virus were present in 5cases; HAV-HEV co-infection being the most common. In children 16(48.5%) presented with HAV, HAV+HEV11 (33.3%), HEV4 (12.12%), HBV1 (3.03%) CONCLUSIONS: Vaccination of adults against hepatitis B is indicated, along with sexual education to decrease the incidence of hepatitis which is found as common etiological agent in adults. The incidence of HAV and HEV in children shows that there is need for improvement in sanitation and food habits.

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Section: Discussionmentioning

confidence: 54%

“…[3][4][5][6][7][8][9] In the present study, HAV (27.5%) was identified to be the most common cause of acute hepatitis followed by HBV (26.25% cases), HEV (22.5% cases) and HCV (0%). The overall prevalence of hepatitis viruses is in accordance with that of other studies mentioned in Table 5.…”

Section: Discussionmentioning

confidence: 90%

Prevalence of Different Viral Markers in Patients of Acute Viral Hepatitis in and Around Visakhapatnam : Hospital Based Study

B¹,

M²,

Raju³

et al. 2015

jemds

View full text Add to dashboard Cite

show abstract

“…[26] Divergent opinion exists over the seroprevalence data of various viral markers in age, sex groups and co infection status. [25,[27][28][29][30][31] The total infective pathology was serologically detected in 128 (21.3%) out of 600 samples suspected of acute infectious hepatitis in the study group while 17 (8.5%) of the 200 samples in control group. Different authors have reported different prevalence rates of acute viral hepatitis in and around Delhi.…”

Section: Discussionmentioning

confidence: 99%

A Descriptive Study on Prevalence, Pattern and Coinfection of Hepatitis Viruses in Acute Infectious Hepatitis

Rajani¹,

Jais²

2016

IJMEDPH

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Introduction:There is variability of data regarding seroprevalence and coinfection of hepatitis viruses. Our objective was to determine the magnitude, pattern and coinfection of hepatitis viruses in clinically suspected cases of acute infectious hepatitis. Methods: This descriptive study was conducted in the Department of Microbiology at Lady Hardinge Medical College, New Delhi, over a period of 1 year from January 2008 to December 2008. All the serum samples taken from subjects (n= 600 in study group and n=200 in control group) were tested for hepatitis B surface antigen (HBsAg), Immunoglobulin M (IgM) antibody against HAV, HCV & HEV using commercially available enzyme linked immunosorbent assay kit. Serum samples positive for HBs Ag were further tested for IgM capture anti hepatitis D virus (HDV) by ELISA methodology. We used SPSS Ver.10.0 (SPSS Inc. Chica go, Illinois) for the statistical analysis. The means of continuous variables among the groups were compared using the Student's t-test while proportions were tested by Chi-square test. Results: Seroprevalence of acute viral hepatitis was 128/600 (21.3%) and 17/200 (8.5%) in study and control group respectively (p<0.05). HAV was the commonest cause 50/600 (8.3%) followed by HCV 33/600 (5.5%), HBV 24/600 (4%) and HEV 21/600 (3.5%). Coinfection rate among the study group was 11/128 (8.5%) and maximum coinfection rates were seen with HBV 8/11 (72%). 4/24 (16.6%) of the HBV infected cases were coinfected with HDV. Male predominance was seen for all the markers. Overall sex wise seropositivity in males was

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“…10 A recent study from Delhi has reported that the frequency of HAV infection among children has increased from 8.4 to 12.3% over a period of five years, with the frequency of HAV infection having increased in adults also from 3.4 to 12.3% during the same period. 11 Similarly, outbreaks of epidemics of hepatitis A have been reported from Kottayam, Kerala State; the infection was traced to the presence of a sewage treatment plant which was overflowing and getting mixed with a canal. 12 Recent reports from India also have shown a variable prevalence in HAV exposure in middle and upper socioeconomic strata.…”

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confidence: 93%

Hepatitis A vaccine should receive priority in National Immunization Schedule in India

Verma

Khanna

2012

Human Vaccines & Immunotherapeutics

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Increasing trend of acute hepatitis A in north India: Need for identification of high‐risk population for vaccination

Abstract: Although universal vaccination against HAV is not currently indicated, selective vaccination of the high-risk population, based on their serological evidence of HAV antibody, would be a rational and cost-effective approach.

Cited by 41 publications

References 33 publications

Prevalence of Different Viral Markers in Patients of Acute Viral Hepatitis in and Around Visakhapatnam : Hospital Based Study

Prevalence of Different Viral Markers in Patients of Acute Viral Hepatitis in and Around Visakhapatnam : Hospital Based Study

A Descriptive Study on Prevalence, Pattern and Coinfection of Hepatitis Viruses in Acute Infectious Hepatitis

Hepatitis A vaccine should receive priority in National Immunization Schedule in India

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