Increasing trend in the prevalence of gestational diabetes mellitus in Taiwan

Su, Feng-Lin; Lu, Ming‐Chi; Yu, Su-Chen; Yang, Chun‐Pai; Yang, Cheng-Chia; Tseng, Shih-Ting; Yan, Yuan-Horng

doi:10.1111/jdi.13595

Cited by 21 publications

(27 citation statements)

References 40 publications

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“…Gestational diabetes mellitus (GDM) is a frequent occurrence in the second trimester of pregnancy, with the risk being greater with increasing age [25][26][27]. Autoimmune diseases like insulin-dependent diabetes mellitus (IDDM), Hashimoto's thyroiditis, pernicious anemia, etc., are more common in women and occur concomitantly.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Subclinical Hypothyroidism in Pregnancy and Its Association With Anti-thyroperoxidase Antibody and the Occurrence of Gestational Diabetes Mellitus

Dash¹,

Tiwari²,

Nayak³

et al. 2022

Cureus

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ConclusionAnti-TPO antibody subsequently leads to hypothyroxinemia, for which it is necessary that cases with high titer of anti-TPO antibody though euthyroid should be meticulously followed up and screened for to detect development of hypothyroidism or SCH, particularly in future pregnancies. However, GDM prevalence was at par with the national figure, but with no significant association of SCH and a high anti-TPO ab titer was found with GDM in our study. Further studies with a larger cohort may establish a causal association between the two most common endocrinological disorders observed in pregnancy.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Subclinical Hypothyroidism in Pregnancy and Its Association With Anti-thyroperoxidase Antibody and the Occurrence of Gestational Diabetes Mellitus

Dash¹,

Tiwari²,

Nayak³

et al. 2022

Cureus

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“…GDM is mainly caused by insufficient secretion of insulin or insulin resistance, and these reasons are currently considered to be related to genetic and environmental factors [ 37 ], such as high childbearing age, family history, or being overweight or obese [ 38 ], or specific ethnicities [ 39 ], among other factors. In recent years, the incidence of type 2 diabetes in Taiwan has also been rising, and the age of onset tends to get younger [ 40 ]. More expectant mothers may have been prediabetic or have type 2 diabetes before pregnancy [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

A Comparative Prevalence of Birth Defects between Newborns of Immigrant and Native-Born Mothers in Taiwan: Ten Years of Population-Based Data

Lin

Chiou

Huang

et al. 2021

IJERPH

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In recent years, newborns born to immigrant mothers have accounted for about 10% of the total births in Taiwan. However, little is known about whether there are differences between newborns of immigrant and native-born mothers regarding the prevalence and the possible causes of birth defects. By combining four nationwide databases and assessing all newborns between 2005 and 2014 in Taiwan as research subjects, this study determined the prevalence of birth defects stratified into nine categories (neuronal, facial, cleft, circulatory, respiratory, digestive, urogenital, musculoskeletal and chromosomal abnormalities) in the newborns of immigrant mothers and native-born mothers. We found that the prevalence of any birth defects in newborns of immigrant mothers (ranging from 0.98 to 1.24%) was lower than that of native-born mothers (2.86%). Skeletomuscular system defects are the most common among newborns of women from the main immigrant countries (0.24–0.42%), while circulatory system defects were the most common among newborns of Taiwanese women (0.92%). The risks of all defects remained lower for newborns of immigrant mothers (AORs ranged from 0.37 to 0.47) after controlling for possible confounding variables. The higher rates of birth defects among newborns of native-born mothers may be attributed to an older maternal age at childbirth and a higher prevalence of diabetes than that of immigrant mothers. The findings from this study imply that the prevalence of birth defects between newborns of immigrant and native-born mothers is not similar, as evidenced by a decade of population-based data.

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“…The prevalence of GDM, which is a form of hyperglycemia that first develops during pregnancy [ 1 ], increases worldwide every year, with prevalence rates varying by ethnicity [ 7 ]. According to the International Diabetes Federation (IDF) Diabetes Atlas for 2021, the prevalence of GDM (20–49 years old) varies from 13% in Africa to 25.9% in Southeast Asia (SEA) [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Genomics and Epigenomics of Gestational Diabetes Mellitus: Understanding the Molecular Pathways of the Disease Pathogenesis

Samra

Jelinek

Alsafar

et al. 2022

IJMS

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One of the most common complications during pregnancy is gestational diabetes mellitus (GDM), hyperglycemia that occurs for the first time during pregnancy. The condition is multifactorial, caused by an interaction between genetic, epigenetic, and environmental factors. However, the underlying mechanisms responsible for its pathogenesis remain elusive. Moreover, in contrast to several common metabolic disorders, molecular research in GDM is lagging. It is important to recognize that GDM is still commonly diagnosed during the second trimester of pregnancy using the oral glucose tolerance test (OGGT), at a time when both a fetal and maternal pathophysiology is already present, demonstrating the increased blood glucose levels associated with exacerbated insulin resistance. Therefore, early detection of metabolic changes and associated epigenetic and genetic factors that can lead to an improved prediction of adverse pregnancy outcomes and future cardio-metabolic pathologies in GDM women and their children is imperative. Several genomic and epigenetic approaches have been used to identify the genes, genetic variants, metabolic pathways, and epigenetic modifications involved in GDM to determine its etiology. In this article, we explore these factors as well as how their functional effects may contribute to immediate and future pathologies in women with GDM and their offspring from birth to adulthood. We also discuss how these approaches contribute to the changes in different molecular pathways that contribute to the GDM pathogenesis, with a special focus on the development of insulin resistance.

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Increasing trend in the prevalence of gestational diabetes mellitus in Taiwan

Cited by 21 publications

References 40 publications

Prevalence of Subclinical Hypothyroidism in Pregnancy and Its Association With Anti-thyroperoxidase Antibody and the Occurrence of Gestational Diabetes Mellitus

Prevalence of Subclinical Hypothyroidism in Pregnancy and Its Association With Anti-thyroperoxidase Antibody and the Occurrence of Gestational Diabetes Mellitus

A Comparative Prevalence of Birth Defects between Newborns of Immigrant and Native-Born Mothers in Taiwan: Ten Years of Population-Based Data

Genomics and Epigenomics of Gestational Diabetes Mellitus: Understanding the Molecular Pathways of the Disease Pathogenesis

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