Increasing the Viability of Fat Grafts by Vascular Endothelial Growth Factor

Topcu, Alpaslan; Aydin, Osman Enver; Ünlü, Mehtat; Barutçu, Ali; Atabey, Atay

doi:10.1001/archfacial.2011.1633

Cited by 34 publications

(15 citation statements)

References 23 publications

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“…Seeds: The seeds must be healthy and have retained their ability to sprout. Although much has been written about the harvesting, preparation, and supercharging of fat grafts with growth factors [3][4][5] and stem cells, 6 controversy remains, and no method has been shown to be clearly superior. We favor simple low-pressure liposuction and minimal centrifugation.…”

mentioning

confidence: 99%

Megavolume Autologous Fat Transfer

Rigotti

Cardoso

Khouri

et al. 2014

Plastic &Amp; Reconstructive Surgery

133

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The authors describe the techniques that use the principles of fat grafting to allow them to successfully graft megavolumes (250-ml range) of autologous fat into breasts. The Brava external volume expansion device preoperatively increases the volume and vascularity of the recipient site. Low-pressure liposuction and minimal centrifugation are used to gently extract and purify the adipose tissue with minimal trauma. Even and diffuse reinjection of the fat increases graft-to-recipient interface and reduces interstitial fluid pressure. Postoperative Brava use protects the graft and acts as a three-dimensional immobilizing splint. By adhering to these techniques, we have been able to graft megavolumes of fat into the breasts of over 1000 patients and obtain substantial long-term volume retention.

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mentioning

confidence: 99%

Megavolume Autologous Fat Transfer

Rigotti

Cardoso

Khouri

et al. 2014

Plastic &Amp; Reconstructive Surgery

133

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“…For the past decades, the perspective that neovascularization in the early phase is pivotal in improving adipocyte survival rate has been widely accepted [16][17][18]. Thereby, all kinds of growth factors, e.g., VEGF, bFGF, IGF-1, HGF, EGF, etc., have been explored hoping to reduce the absorbance and most of them achieved satisfying results [19][20][21][22][23][24]. Due to the fact that most of these factors are susceptible, expensive, require a carrier and, most serious of all, are linked to tumor risks [25][26][27][28][29][30][31], clinical use is strongly restricted and limited.…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese Medicine: Salvia miltiorrhiza Enhances Survival Rate of Autologous Adipose Tissue Transplantation in Rabbit Model

Zhang

et al. 2015

Aesth Plast Surg

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This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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“…As fat transplantation has evolved, major improvements have also been made to the techniques and factors listed above. In addition, methods have been developed to improve fat cell survival by incorporating new additives, such as insulin, vascular endothelial growth factor (VEGF), and PRP [10,12,13]. Among these methods, autologous PRP-assisted fat grafting is emerging as an attractive option.…”

Section: Discussionmentioning

confidence: 99%

A novel cannula for uniform mixing of liquid substances

Kim¹,

Kim

et al. 2019

Arch Aesthetic Plast Surg

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Uniform mixing of liquid substances is difficult to attain. Recently, mixtures of fat and platelet-rich plasma (PRP) have been used extensively in autologous fat transfer. Although various methods have been utilized to mix the fat and PRP involved in this procedure, these methods still carry disadvantages in the time taken and the potential for cell damage, and it is questionable whether effective mixing can occur using these techniques. To facilitate mixing that is as uniform as possible, the authors of this study invented a special cannula. Use of the conventional luer-lock-to-luer-lock connector method has been found to cause cell damage and makes it difficult to achieve uniform mixing, while random injection-type mixing has been shown to have limited accuracy and effectiveness. We expect that the newly designed cannula will solve the problem detailed above.

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Increasing the Viability of Fat Grafts by Vascular Endothelial Growth Factor

Abstract: This study suggests that VEGF-induced preconditioning of the recipient bed improves fat graft viability via increased revascularization.

Cited by 34 publications

References 23 publications

Megavolume Autologous Fat Transfer

Megavolume Autologous Fat Transfer

Traditional Chinese Medicine: Salvia miltiorrhiza Enhances Survival Rate of Autologous Adipose Tissue Transplantation in Rabbit Model

A novel cannula for uniform mixing of liquid substances

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