Increasing the rate of heating: A potential therapeutic approach for achieving synergistic tumour killing in combined hyperthermia and chemotherapy

Tang, Yuan; McGoron, Anthony J.

doi:10.3109/02656736.2012.760757

Cited by 34 publications

(24 citation statements)

References 41 publications

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“…Improved cancer cell killing can be achieved with a combination of HT and chemotherapy. Our previous study demonstrated that mild cell apoptosis can be induced by mild HT [38]. Furthermore, the therapeutic effect of DOX can be potentially augmented because mild HT can enhance cell membrane permeability and fluidity, and in turn result in accumulation of drug inside cancer cells, especially for MDR cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Thermal and pH sensitive multifunctional polymer nanoparticles for cancer imaging and therapy

et al. 2014

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In this study, we prepared novel poly(Glycerol malate co-dodecanedioate) (PGMD) NPs containing an imaging/hyperthermia agent (IR820) and a chemotherapeutic agent (doxorubicin, DOX). The PGMD polymer was prepared by thermal condensation. IR820 and DOX loaded PGMD NPs were prepared using the single oil emulsion technique. The size of the NPs measured was around 150 nm. Drug loading efficiency of DOX and IR820 was around 4% and 8%, respectively. An acidic environment (pH=5.0) induced higher DOX release as compared to pH=7.4. DOX release was also enhanced by exposure to laser, which increased the temperature to 42°C. Cytotoxicity of the drug loaded NPs was comparable in MES-SA but was higher in Dx5 cells compared to free drug (p<0.05). The combination of hyperthermia and chemotherapy improved cytotoxicity in both cell lines. The NP formulation significantly improved the plasma half-life of IR820 in mice after tail vein injection.

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Section: Discussionmentioning

confidence: 99%

Thermal and pH sensitive multifunctional polymer nanoparticles for cancer imaging and therapy

et al. 2014

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“…Hyperthermia by ICG (37°C to 43°C within 1 minute) is also a safe approach to help doxorubicin, a chemotherapy drug, overcome multidrug resistance. 175 Due to limitations such as poor photostability, self-aggregation, rapid elimination from the body, and lack of target specificity, ICG is usually encapsulated into the core of a polymeric micelle. Interestingly, ICG-encapsulated micelles are still available for potential application in tumor photothermal therapy.…”

mentioning

confidence: 99%

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Yi¹,

Wang²,

Qin³

et al. 2014

IJN

210

149

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Near-infrared fluorescence (NIRF) imaging is an attractive modality for early cancer detection with high sensitivity and multi-detection capability. Due to convenient modification by conjugating with moieties of interests, NIRF probes are ideal candidates for cancer targeted imaging. Additionally, the combinatory application of NIRF imaging and other imaging modalities that can delineate anatomical structures extends fluorometric determination of biomedical information. Moreover, nanoparticles loaded with NIRF dyes and anticancer agents contribute to the synergistic management of cancer, which integrates the advantage of imaging and therapeutic functions to achieve the ultimate goal of simultaneous diagnosis and treatment. Appropriate probe design with targeting moieties can retain the original properties of NIRF and pharmacokinetics. In recent years, great efforts have been made to develop new NIRF probes with better photostability and strong fluorescence emission, leading to the discovery of numerous novel NIRF probes with fine photophysical properties. Some of these probes exhibit tumoricidal activities upon light radiation, which holds great promise in photothermal therapy, photodynamic therapy, and photoimmunotherapy. This review aims to provide a timely and concise update on emerging NIRF dyes and multifunctional agents. Their potential uses as agents for cancer specific imaging, lymph node mapping, and therapeutics are included. Recent advances of NIRF dyes in clinical use are also summarized.

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“…By treating MCF-7/ADR cells with hyperthermia, the cell viability was decreased from 46.5% to 33.6% (P < 0.05) with an increase of DOX concentration from 1.0 g/mL to 5.0 g/mL. As reported by Tang et al, hyperthermia effect can increase cell membrane permeability, consequently enhances growth inhibition and sensitization of multidrug resistance cells to DOX [35]. The cytotoxic effect of MCF-7/ADR cells co-treated with NIR irradiation for 4 min (dialyzed CS-N-Arg/ICG NPs) and DOX (5 g/mL) was enhanced due to the simultaneous combination of NIR hyperthermia and chemotherapeutic effects as compared to the results in Fig.…”

Section: Cellular Uptake and Cytotoxicitymentioning

confidence: 51%

Free DOX and chitosan- N -arginine conjugate stabilized indocyanine green nanoparticles for combined chemophotothermal therapy

Jheng

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Increasing the rate of heating: A potential therapeutic approach for achieving synergistic tumour killing in combined hyperthermia and chemotherapy

Abstract: This study shows that by increasing the rate of heating, less thermal dose is needed in order to overcome P-gp mediated MDR.

Cited by 34 publications

References 41 publications

Thermal and pH sensitive multifunctional polymer nanoparticles for cancer imaging and therapy

Thermal and pH sensitive multifunctional polymer nanoparticles for cancer imaging and therapy

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Free DOX and chitosan- N -arginine conjugate stabilized indocyanine green nanoparticles for combined chemophotothermal therapy

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