Increasing the production of insulin glargine in Pichia pastoris through medium modification
Dudi Hardianto,
Anna Safarrida,
Gilang Surya Prayoga
et al.
Abstract:Insulin is the primary drug for managing diabetes mellitus, especially for individuals with type 1 diabetes mellitus. Producing insulin glargine, a long-acting insulin analogue, using Pichia pastoris is a notable advancement in biopharmaceutical manufacturing. This research aims to increase the yield of insulin glargine in Pichia pastoris. The effects of these mediums and vitamins on cell growth and insulin glargine expression levels were evaluated. The findings revealed that the addition of vitamins to the mi… Show more
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