Increasing the accuracy of peanut allergy diagnosis by using Ara h 2

Dang, Thanh; Tang, Mimi L.K.; Choo, Sharon; Licciardi, Paul V.; Koplin, Jennifer J.; Martin, Pamela E.; Tan, T.; Gurrin, Lyle C.; Ponsonby, Anne–Louise; Tey, Dean; Robinson, Marnie; Dharmage, Shyamali C.; Allen, Katrina J.

doi:10.1016/j.jaci.2012.01.056

Cited by 219 publications

(213 citation statements)

References 16 publications

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“…The analysis of ImmunoCAP ISAC data revealed that 4 of them were sensitized to CCDs and 2 of those 4 were sensitized to profilins, but the remaining 3 subjects showed no sensitization to allergens with potential cross-reactivity to peanut. This observation, also reported by others [11,14,18], indicates that additional peanut allergens might be implicated in peanut hypersensitivity in these patients. Although the peanut oleosins (Ara h 10, Ara h 11), peanut defensins (Ara h 12, Ara h 13) and an additional 2S albumin (Ara h 7) have been identified as allergens, data about their clinical relevance for peanut-allergic patients are very scarce [25], suggesting that large-scale studies to evaluate the sensitization patterns to these components in peanut-allergic patients are required.…”

Section: Discussionsupporting

confidence: 87%

“…Our findings confirm observations from other peanut CRD studies that have demonstrated that this allergen panel enables the majority of peanut-allergic patients to be identified [1,18]. However, although the peanut extract was absolutely discriminative between patients with suspected peanut allergy and nonatopic controls, a positive sIgE result for peanut extract did not reflect the clinical relevance as it was also found in 75% of individuals without an apparent peanut allergy.…”

Section: Discussionsupporting

confidence: 75%

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Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy

Ackerbauer

Bublin

Radauer

et al. 2015

Int Arch Allergy Immunol

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Background: Peanut allergy develops after primary sensitization to peanut allergens and/or IgE cross-sensitization with homologous allergens from various plants. Therefore, heterogeneous patterns of sensitization to individual peanut allergens are observed in different countries. The aim of this study was to examine the IgE sensitization patterns of Austrian peanut-allergic patients. Methods: Sera from 65 peanut-allergic patients and 20 peanut-tolerant atopics were obtained in four Austrian allergy clinics.Sensitization patterns against peanut allergens Ara h 1-3, 6, 8 and 9 were identified by ImmunoCAP and ImmunoCAP ISAC. Results: Austrian peanut-allergic patients were sensitized to Ara h 2 and 6 (71%), followed by Ara h 1 (62%), Ara h 8 (45%), Ara h 3 (35%) and Ara h 9 (11%). All sera containing Ara h 2-specific IgE were also positive for Ara h 6, with Ara h 6-specific IgE levels significantly (p < 0.05) higher compared with Ara h 2. Twelve percent displayed IgE reactivity exclusively to Ara h 8. Peanut extract and Ara h 8 showed low diagnostic specificities of 25 and 10%, respectively. The other peanut allergens showed 100% specificity. Diagnostic sensitivities determined by ImmunoCAP ISAC and ImmunoCAP were highly similar for Ara h 2, 3 and 8. Conclusions: Themajority of symptomatic peanut-allergic patients are sensitized to Ara h 2 and Ara h 6. In peanut-symptomatic patients with additional birch pollen allergy, other peanut allergens, especially Ara h 8, should be tested when IgE reactivity to Ara h 2 is absent.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 75%

Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy

Ackerbauer

Bublin

Radauer

et al. 2015

Int Arch Allergy Immunol

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“…In Japan, Ebisawa et al [9] found that measurement of Ara h 1-, 2-, and 3-specific immunoglobulin E (IgE) antibodies was useful for the diagnosis of peanut allergy in Japanese children and that rAra h 2 ImmunoCAP testing was able to differentiate between peanut-allergic and asymptomatic peanut-sensitized children, similar to studies from Western countries [10,11,12]. Component-resolved diagnosis of PA in Taiwan also showed that Ara h 1-3 were the major peanut allergens in local patients, and peanut-allergic children had persistent elevation of Ara h 2-specific IgE [13].…”

Section: Introductionmentioning

confidence: 83%

Component-Resolved Diagnosis of Peanut Allergy and Its Possible Origins of Sensitization in China

Nie

et al. 2016

Int Arch Allergy Immunol

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Background: Clinical and immunological characteristics of food allergies vary depending on geographic regions. Little is known about peanut allergy in China. The aim of this study was to investigate the peanut sensitization profile in China. Methods: Thirty-eight participants with immunoglobulin E (IgE)-positive responses to peanuts (peanut-sensitized) were included in our study, and clinical characteristics were evaluated. Total and specific IgE reactivity against peanuts, other plant-derived foods, pollens, and related allergen components were determined. Results: Eighteen patients were symptomatic when exposed to peanuts. The majority of them presented with systemic reactions. More than half of the peanut-sensitized subjects also suffered from mugwort pollinosis and peach allergy. In patients with both peanut and peach allergies, reactions to peanuts were the same as or severer than those to peaches. Positivity rates of IgE response to rAra h 1-3, 8, and 9 in the peanut allergy group were 5.6, 11.1, 5.6, 22.2, and 83.3%, respectively. 66.7% (12/18) of the peanut-allergic patients were monosensitized to rAra h 9. Anti-nArt v 3 [mugwort nonspecific lipid transfer protein (nsLTP)] IgE positivity in the peanut allergy group was significantly higher than that in the asymptomatic peanut-sensitized group. In Ara h 9 (peanut nsLTP)-sensitized patients with mugwort pollinosis, anti-nArt v 3 IgE levels were remarkably higher than anti-rAra h 9 (peanut nsLTP) IgE levels as well as anti-Pru p 3 (peach nsLTP) IgE levels. Conclusions: Ara h 9 was the major allergen of peanut, and Ara h 9 monosensitization was the most common peanut sensitization pattern in our population. Furthermore, there was a strong correlation between peanut sensitization and mugwort pollinosis, as well as peach allergy, in our country.

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“…Так, сенсибилизация к аллергену арахиса rAra h2 в Европе среди пациентов детского возраста составляет более 60% и является ключевым маркером аллергических реакций к арахису [14][15][16].…”

Section: результаты и обсуждениеunclassified

Specific features of sensitization to recombinant peanut allergens in children with anaphylaxis

Шуляева¹,

Пампура²,

Окунева³

2016

Ross. vestn. perinatol. pediatr.

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Increasing the accuracy of peanut allergy diagnosis by using Ara h 2

Cited by 219 publications

References 16 publications

Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy

Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy

Component-Resolved Diagnosis of Peanut Allergy and Its Possible Origins of Sensitization in China

Specific features of sensitization to recombinant peanut allergens in children with anaphylaxis

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