Increasing Rigor of Preclinical Research to Maximize Opportunities for Translation

Radabaugh, Hannah L.; Ferguson, Adam R.; Bramlett, Helen M.; Dietrich, W. Dalton

doi:10.1007/s13311-023-01400-5

Neurotherapeutics

2023

DOI: 10.1007/s13311-023-01400-5

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Increasing Rigor of Preclinical Research to Maximize Opportunities for Translation

Hannah L. Radabaugh,

Adam R. Ferguson,

Helen M. Bramlett

et al.

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Cited by 4 publications

References 85 publications

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Pharmacotherapy for Traumatic Brain Injury: The Next Generation of Clinical Trials

Diaz-Arrastia,

Kochanek

2023

Neurotherapeutics

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Pharmacotherapy for Traumatic Brain Injury: The Next Generation of Clinical Trials

Diaz-Arrastia,

Kochanek

2023

Neurotherapeutics

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Editorial: Revisiting mouse models of traumatic brain injuries: a focus on intracellular mechanisms

Omais,

Kobeissy,

Zibara

et al. 2024

Front. Cell. Neurosci.

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A Systematic Review of Traumatic Brain Injury in Modern Rodent Models: Current Status and Future Prospects

Balakin,

Yurku,

Fomina

et al. 2024

Biology

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According to the Centers for Disease Control and Prevention (CDC), the national public health agency of the United States, traumatic brain injury is among the leading causes of mortality and disability worldwide. The consequences of TBI include diffuse brain atrophy, local post-traumatic atrophy, arachnoiditis, pachymeningitis, meningocerebral cicatrices, cranial nerve lesions, and cranial defects. In 2019, the economic cost of injuries in the USA alone was USD 4.2 trillion, which included USD 327 billion for medical care, USD 69 billion for work loss, and USD 3.8 trillion for the value of statistical life and quality of life losses. More than half of this cost (USD 2.4 trillion) was among working-age adults (25–64 years old). Currently, the development of new diagnostic approaches and the improvement of treatment techniques require further experimental studies focused on modeling TBI of varying severity.

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Increasing Rigor of Preclinical Research to Maximize Opportunities for Translation

Cited by 4 publications

References 85 publications

Pharmacotherapy for Traumatic Brain Injury: The Next Generation of Clinical Trials

Pharmacotherapy for Traumatic Brain Injury: The Next Generation of Clinical Trials

Editorial: Revisiting mouse models of traumatic brain injuries: a focus on intracellular mechanisms

A Systematic Review of Traumatic Brain Injury in Modern Rodent Models: Current Status and Future Prospects

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