Increasing Resistance of Brucellae to Co-Trimoxazole

Kinsara, Abdulhalim Jamal; Al-Mowallad, A.; Osoba, Abimbola O.

doi:10.1128/aac.43.6.1531

Cited by 33 publications

(16 citation statements)

References 3 publications

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“…Development of resistance to TMP/SMX to B. melitensis is an important issue. High rate of resistance to TMP/SMX has been reported from previous studies [17, 29]. In the present study, TMP/SMX was found to be susceptible with low MIC 50 (0.064 mg/L) and MIC 90 (0.25 mg/L) when compared to other antimicrobials which is consistent with previous reports [9, 13, 15].…”

Section: Discussionsupporting

confidence: 92%

“…However, ciprofloxacin is not recommended for monotherapy due to the lack of bactericidal activity at the intracellular acidic pH [31], high rate of relapse and the risk of development of overall fluoroquinolone resistance in the community [32]. Therefore, its use in combination with doxycycline is recommended as an acceptable alternative but not as first line regimen [29, 33]. We found ciprofloxacin MICs (0.064–0.5 mg/L) in the susceptible range when compared to MIC breakpoint criteria of slow growing bacteria and these findings are consistent with previous studies [9, 16].…”

Section: Discussionmentioning

confidence: 99%

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In vitro antimicrobial susceptibility testing of human Brucella melitensis isolates from Qatar between 2014 – 2015

et al. 2015

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BackgroundBrucellosis is one of the most common zoonotic disease affecting humans and animals and is endemic in many parts of the world including the Gulf Cooperation Council region (GCC). The aim of this study was to identify the species and determine the antimicrobial susceptibility pattern of Brucella strains isolated from clinical specimens, from Qatar.ResultsWe evaluated 231 Brucella isolates. All isolates were identified as B. melitensis. All the isolates were susceptible to doxycycline, tetracycline, streptomycin, gentamicin, trimethoprim / sulfamethoxazole and ciprofloxacin except rifampicin, where 48 % of the strains showed elevated MICs (>1 mg/L). The rifampicin-resistance related hotspots within the rpoB gene were amplified and sequenced using PCR and no rpoB mutations were found in strains with rifampicin MICs of >2 mg/L.ConclusionThis study identified B. melitensis as the etiological agent of brucellosis in Qatar. No resistant isolates were detected among conventionally used antimicrobial agents.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

In vitro antimicrobial susceptibility testing of human Brucella melitensis isolates from Qatar between 2014 – 2015

et al. 2015

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“…Kinsara et al reported 38% of 37 brucella isolates sensitive to TMP-SMX. They also reported all but one isolate sensitive to rifampicin, tetracycline, gentamicin and ciprofloxacin [15].…”

Section: Discussionmentioning

confidence: 97%

In vitro antimicrobial susceptibility of Brucella species

Baykam

Esener

Ergönül

et al. 2004

International Journal of Antimicrobial Agents

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“…In vitro TMP-SMZ resistance rate was reported 2% in Turkey 8. However, significant rates of TMP-SMZ resistance have been reported in the world 31,34.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Susceptibilities of Brucella Isolates from Various Clinical Speciemens

Bayram¹,

Körkoca²,

Aypak³

et al. 2011

Int. J. Med. Sci.

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Purpose: Brucellosis is a worldwide zoonotic disease and still constitutes a major public health problem. In the study we claimed to identify Brucella species from clinical samples of patients with active brucellosis from Van region of Eastern Anatolia and to determine in vitro antimicrobial susceptibilities of these strains to commonly used anti-Brucella agents and a possible new alternative tigecycline.Materials and Methods: A total of 56 Brucella isolates were enrolled the study and the identification of the isolates were based on conventional methods. In vitro activities of antimicrobials were evaluated by the E test method.Results: All isolates were identified as B. melitensis. MIC90 values of doxycycline, streptomycin, rifampin, trimethoprim-sulfamethoxazole and tigecycline were 0.064 mg/L, 1 mg/L, 2 mg/L, 0.125 mg/L and 0.094 mg/L, respectively. Tigecycline had low MIC50 and MIC90 values against all B. melitensis strains; the highest MIC observed was 0.25 μg/mL.Conclusion: Our data suggest that tigecycline can be a therapeutic alternative option for the treatment of brucellosis.

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Increasing Resistance of Brucellae to Co-Trimoxazole

Cited by 33 publications

References 3 publications

In vitro antimicrobial susceptibility testing of human Brucella melitensis isolates from Qatar between 2014 – 2015

In vitro antimicrobial susceptibility testing of human Brucella melitensis isolates from Qatar between 2014 – 2015

In vitro antimicrobial susceptibility of Brucella species

Antimicrobial Susceptibilities of Brucella Isolates from Various Clinical Speciemens

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