Increasing Rates of Penicillin Sensitivity in Staphylococcus aureus

Butler‐Laporte, Guillaume; Lee, Todd C.; Cheng, Matthew P.

doi:10.1128/aac.00680-18

Cited by 12 publications

(8 citation statements)

References 5 publications

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“…This trend has now been observed on several continents and has been shown to involve bloodstream infections and other serious infections (Cheng et al, 2016). In the United states, this increase in the incidence of PSSA infections has also been mirrored by a decrease in /methicillin-resistant S. aureus infection rates (Butler-Laporte et al, 2018) .…”

Section: Discussionmentioning

confidence: 95%

Prevalence and antimicrobial susceptibility pattern of Staphylococcus Aureus isolated from clinical specimens at the Mater Hospital Nairobi, Kenya.

Okello

Achieng

Mwachari

et al. 2020

Preprint

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Staphylococcus aureus is a leading cause of hospital and community acquired infections globally. Surveillance of prevalence and antibiotic susceptibility patterns is important to ensure appropriate antibiotic prescription. The aim of this study was to determine the prevalence and susceptibility patterns of Staphylococcus aureus isolated from clinical specimens in a tertiary referral and training hospital.A retrospective study was conducted at the Mater Misericordiae Hospital, Nairobi.It involved analyzing records of specimens analyzed between January 2014 and December 2018. Strains phenotypically resistant to <3 non β-lactam antimicrobial categories were defined as non-multidrug-resistant MRSA (nmMRSA) and strains that were resistant to ≥3 non-β-lactam antimicrobial groups were defined as multidrug-resistant MRSA (mMRSA). A specimen was categorized as Penicillin susceptible (PSSA) if susceptible to Penicillin and Oxacillin, MSSA if resistant to Penicillin and susceptible to Oxacillin, and MRSA if resistant to Oxacillin and Penicillin.ResultsPSSA accounted for 60.85%, (401/659)of S.aureus cultured.The prevalence of MSSA was 38.54%(254/659).MRSA was the least prevalent.(0.61%,4/659).No multi-drug Methicillin resistant S. aureus were isolated in the five-year period.PSSA accounted for 60.85%(401/659)of all S.aureus isolates.100% of MRSA isolated was sensitive to Vancomycin, Linezolid, Tigecycline, Tetracycline and Rifampicin. MRSA was resistant to Clindamycin and Erythromycin.Conclusion;The prevalence of MRSA was low compared to previous studies.All strains isolated were non-multidrug resistant.There was no resistance to Vancomycin detected.Penicillins are still a viable option in the treatment of majority of S.aureus infections in our setting.

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Section: Discussionmentioning

confidence: 95%

Prevalence and antimicrobial susceptibility pattern of Staphylococcus Aureus isolated from clinical specimens at the Mater Hospital Nairobi, Kenya.

Okello

Achieng

Mwachari

et al. 2020

Preprint

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“…While scientists have paid increasing attention to more-resistant strains, and studies have often underestimated the significance of methicillin-sensitive S. aureus strains for years, penicillin-sensitive S. aureus strains appear to have crept back in “under the radar”. In some developed countries, such as the USA, Spain, France and Canada, researchers have reported that the proportion of penicillin-susceptible S. aureus is approximately 15–45% [ 11 , 15 , 25 , 32 ]. Penicillin is a narrow-spectrum agent that offers several advantages, such as lower average MIC and treatment cost and better theoretical pharmacokinetic and pharmacodynamic profiles compared with the usual first-line treatments.…”

Section: Discussionmentioning

confidence: 99%

Genomic epidemiology and characterisation of penicillin-sensitive Staphylococcus aureus isolates from invasive bloodstream infections in China: an increasing prevalence and higher diversity in genetic typing be revealed

Jin

Zhou

Zhan

et al. 2022

Emerging Microbes & Infections

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Many countries have reported increasing rates of penicillin-susceptible methicillin-sensitive Staphylococcus aureus (MSSA-PEN S ). To date, there is relatively little known about the current situation and molecular characteristics of MSSA-PEN S in China. In this study, we carried out a laboratory-based multi-region retrospective study to investigate the genomic epidemiology and characterisation of MSSA-PEN S isolated from invasive bloodstream infections (BSIs) across 17 provinces. The prevalence of MSSA-PEN S isolates increased significantly over the 6-year period, with the proportion increasing from 3.51% in 2014–8.80% in 2019, an average relative increase of 22.14% per year (95% confidence interval 9.67%-34.61%, P for trend <0.001), suggesting that China is experiencing a resurgence of MSSA-PEN S . Phylogenetic analysis showed a higher strain diversity occurred; the most frequent clonal complexes (CCs) identified were CC188 (17.14%), CC398 (15.71%) and CC5 (15.71%). Over half of MSSA-PEN S strains were pan-susceptible, with erythromycin the most frequent resistance observed. Moreover, 25 isolates were identified as immune evasion cluster negative, including CC15, CC188 and CC1, and 6 strains encoded the Panton-Valentine leucocidin gene. Importantly, virulence assays showed that MSSA-PEN S exhibited a level of virulence comparable to that of penicillin-resistant MSSA (MSSA-PEN R ), indicating that more-sensitive strains should not be mistaken for lacking aggressiveness in vivo . Furthermore, 11 of these isolates were confirmed as blaZ positive but phenotype sensitive, with different amino acid changes in blaZ . Our data support the recommendation to clinicians regarding the usage of penicillin in invasive BSIs caused by MSSA-PEN S , which might create a novel opportunity for better antimicrobial stewardship in the future.

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“…This trend has now been observed on several continents [20] and has been shown to involve bloodstream infections and other serious infections [21]. This increase in the incidence of PSSA infections has also been accompanied by a decrease in methicillin-resistant 10 S. aureus (MRSA) infection rates [3,19].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and antimicrobial susceptibility pattern of Staphylococcus Aureus isolated from clinical specimens at the Mater Hospital Nairobi, Kenya.

Okello

Achieng

Mwachari

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Staphylococcus aureus is a leading cause of hospital and community acquired infections globally. Surveillance of prevalence and antibiotic susceptibility patterns is important to ensure appropriate antibiotic prescription. The aim of this study was to determine the prevalence and susceptibility patterns of Staphylococcus aureus isolated from clinical specimens in a tertiary hospital with diverse and empirical prescribing habits. Methods A retrospective study was conducted at the Mater Misericordiae Hospital, Nairobi. The study involved records of specimens analyzed between January 2014 and December 2018. S aureus was identified using catalase and coagulase tests. Strains phenotypically resistant to <3 non β-lactam antimicrobial categories were defined as non-multidrug-resistant MRSA (nmMRSA) and strains that were resistant to ≥3 non-β-lactam antimicrobial groups were defined as multidrug-resistant MRSA (mMRSA). A specimen was categorized as Penicillin susceptible (PSSA) if susceptible to penicillin and oxacillin, MSSA if resistant to penicillin and susceptible to oxacillin, and MRSA if resistant to oxacillin and penicillin. Isolates were screened for MRSA using 6μg/ml of oxacillin disc in Mueller-Hinton agar supplemented with 4%NaCl.Data was analyzed using Statistical Package for Social Sciences(SPSS) version 20 software. Pearson’s chi square and Logistic regression were used to assess association between dependent and independent variables. Results A total of 890 specimens of S. aureus were analyzed in the 5-year period. PSSA was the most prevalent organism seen (45%) while MRSA was the least prevalent (0.45% ). There was a fluctuation in the annual prevalence of MRSA between 0-1% over the five years. Most S. aureus was isolated in pus-644(73. 3%). A significant increase in susceptibility of S. aureus to Penicillin and Amoxicillin-clavulanic acid was observed during the study period however, sensitivity to Amoxicillin declined. No mMrsa was detected. Resistance of MRSA to Ampicillin, Penicillin, Tazopiperacillin, Cephalosporins, Erythromycin, Clindamycin, Ciprofloxacin and Meropenem was 100% with both Trimethoprim/sulfamethoxazole and Levofloxacin recording 50% and amoxicillin/clavulanic acid 75% resistance. Conclusion This study demonstrated a steady decline in average annual resistance of S. aureus to commonly used antibiotics. Furthermore, there was a low prevalence of MRSA. No multi-drug Methicillin resistant S. aureus have been isolated in the last five years in this hospital.

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Increasing Rates of Penicillin Sensitivity in Staphylococcus aureus

Cited by 12 publications

References 5 publications

Prevalence and antimicrobial susceptibility pattern of Staphylococcus Aureus isolated from clinical specimens at the Mater Hospital Nairobi, Kenya.

Prevalence and antimicrobial susceptibility pattern of Staphylococcus Aureus isolated from clinical specimens at the Mater Hospital Nairobi, Kenya.

Genomic epidemiology and characterisation of penicillin-sensitive Staphylococcus aureus isolates from invasive bloodstream infections in China: an increasing prevalence and higher diversity in genetic typing be revealed

Prevalence and antimicrobial susceptibility pattern of Staphylococcus Aureus isolated from clinical specimens at the Mater Hospital Nairobi, Kenya.

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