Increasing rates of NCCN high and very high‐risk prostate cancer versus number of prostate biopsy cores

Abstract

Background: Recently, an increase in the rates of high-risk prostate cancer (PCa) was reported. We tested whether the rates of and low, intermediate, high and very high-risk PCa changed over time. We also tested whether the number of prostate biopsy cores contributed to changes rates over time.Methods: Within the Surveillance, Epidemiology and End Results (SEER) database (2010)(2011)(2012)(2013)(2014)(2015), annual rates of low, intermediate, high-risk according to traditional National Comprehensive Cancer Network (NCCN) and high versus very high-risk PCa according to Johns Hopkins classification were tabulated without and with adjustment for the number of prostate biopsy cores.Results: In 119,574 eligible prostate cancer patients, the rates of NCCN low, intermediate, and high-risk PCa were, respectively, 29.7%, 47.8%, and 22.5%. Of high-risk patients, 39.6% and 60.4% fulfilled high and very high-risk criteria. Without adjustment for number of prostate biopsy cores, the estimated annual percentage changes (EAPC) for low, intermediate, high and very high-risk were respectively −5.5% (32.4%-24.9%, p < .01), +0.5% (47.6%-48.4%, p = .09), +4.1% (8.2%-9.9%, p < .01), and +8.9% (11.8%-16.9%, p < .01), between 2010 and 2015. After adjustment for number of prostate biopsy cores, differences in rates over time disappeared and ranged from 29.8%-29.7% for low risk, 47.9%-47.9% for intermediate risk, 8.9%-9.0% for high-risk, and 13.6%-13.6% for very high-risk PCa (all p > .05). Conclusions:The rates of high and very high-risk PCa are strongly associated with the number of prostate biopsy cores, that in turn may be driven by broader use magnetic resonance imaging (MRI).

Increased risk of postoperative in‐hospital complications after radical prostatectomy in patients with prior organ transplant

“…Finally, differences in RP rates over time in transplant patients were estimated with estimated annual percent change (EAPC) that relied on log-linear methodology, as previously reported. [19][20][21] All tests were two sided with a level of significance set at p < 0.05 and R software environment for statistical computing and graphics (version 3.4.3) was used for all analyses.…”

Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma

“…To access temporal trends in non-SCC and SCC penile cancer, log linear regressions were used to compute estimated annual percent changes (EAPC), as previously described [ 28 , 29 ]. Moreover, Kaplan–Meier plots were fitted to test the effects of non-SCC on CSM across different tumor stages of localized (T 1-2 N 0 M 0 ), locally invasive (T 3-4 N 0 M 0 /T 1-2 N 1-3 M 0 ), and metastatic stages (T 1-4 N 0-3 M 1 ), relative to SCC penile cancer.…”

Contemporary seminal vesicle invasion rates in NCCN high‐risk prostate cancer patients

“…National Comprehensive Cancer Network (NCCN) high-risk prostate cancer (PCa) patients account for 25% of most contemporary nonmetastatic PCa cases in the United States. 1 Of those PCa patients, 38% harbor non-organ confined (NOC) disease. 2,3 Unfortunately, specific seminal vesicle invasion (SVI, pT3b) rates are not known, since SVI rates have invariably been reported in combination with ECE (pT3a/pT3b) and/or with higher stage (pT3b/pT4).…”

“…National Comprehensive Cancer Network (NCCN) high‐risk prostate cancer (PCa) patients account for 25% of most contemporary nonmetastatic PCa cases in the United States 1 . Of those PCa patients, 38% harbor non‐organ confined (NOC) disease 2,3 .…”