Increasing prevalence of specific IgE to aeroallergens in an adult population: Two cross-sectional surveys 8 years apart

Linneberg, Allan; Nielsen, Niels; Madsen, Flemming; Frølund, L.; Dirksen, Asger; Jørgensen, Torben

doi:10.1067/mai.2000.108312

Cited by 143 publications

(146 citation statements)

References 19 publications

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“…an increase among subjects born in the fifties as has been reported by others [31,32]. The results from the current study suggest that the rising trend in allergic sensitisation has come to an end among cohorts born in the late seventies and eighties.…”

Section: Discussionsupporting

confidence: 72%

No further increase in asthma, hay fever and atopic sensitisation in adolescents living in Switzerland

Braun‐Fahrländer

Gassner²,

Grize³

et al. 2004

Eur Respir J

193

124

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Prevalence rates of childhood asthma and allergy have been on the increase for several decades. The present study investigated whether this trend continued during the 1990s in adolescents living in Switzerland.Between 1992 and 2000, the change in prevalence of specific immunoglobulin E to aeroallergens, asthma symptoms and hay fever symptoms assessed by parents9 and students9 answers to the International Study of Asthma and Allergies in Childhood questions was investigated using three cross-sectional surveys. In total 1,324 (74.9%), 1,668 (80.6%) and 1,250 (73.9%) adolescents participated.Prevalence rates of asthma and current asthmatic symptoms remained constant, irrespective of whether the assessment was based on parental questionnaires or the student9s self-completed written or video questionnaires (students9 report of current wheeze 8.8, 7.3, and 8.3%). Similarly, no further increase was observed for reported hay fever rates and allergic sensitisation rates (positive multiscreen allergy test, SX1-test: 34.6, 38.9, and 35.6%, respectively). Although time trends in the occurrence of a series of known risk factors were recorded, none of these factors had a significant impact on asthma and allergy prevalence over time.No further increase in asthma and allergy rates occurred during the 1990s in adolescents living in Switzerland. However, to adequately assess the trend a longer period of observation is needed.

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Section: Discussionsupporting

confidence: 72%

No further increase in asthma, hay fever and atopic sensitisation in adolescents living in Switzerland

Braun‐Fahrländer

Gassner²,

Grize³

et al. 2004

Eur Respir J

193

124

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“…An increase in the prevalence of allergic rhinitis has been observed over the past 40 y of the last millennium (252,721,847,897,(942)(943)(944)(945)(946)(947)(948)(949)(950). In a study in Australia with 50% aborigines, it was found that allergic rhinitis increased from 1982 to 1992 but not in 1997 (951).…”

Section: Variations In Allergy Prevalencementioning

confidence: 99%

“…Prevalence of rhinitis in patients with asthma. The majority of patients with asthma experience rhinitis symptoms (277,648,909,937,945,1882,(1888)(1889)(1890)(1891)(1892)(1893)(1894)(1895)(1896)(1897)(1898)(1899). However, in many instances, symptoms may predominate in one organ and be hidden or unrecognized in other organs even though they exist.…”

Section: Epidemiologic Links Between Rhinitis and Asthmamentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,754

1,761

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“…Over the last decades, the prevalence of atopic and allergic diseases in Western countries increased (Burr et al, 1989;Linneberg et al, 2000;Heinrich et al, 2002). These diseases are supposed to have a multifactorial background with genetic determinants and environmental factors contributing to their development (von Mutius, 2000;Strachan et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Allergic sensitisation and allergic rhinitis are associated with n-3 polyunsaturated fatty acids in the diet and in red blood cell membranes

et al. 2005

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Objective: Due to inconsistent results based on dietary intake data, unsaturated fatty acids in red blood cell (RBC) membranes and diet were used to investigate their association with allergic sensitisation and allergic rhinitis. Design: Cross-sectional, population-based study. Setting: Bavarian Nutrition Survey II (2002-03), Germany. Subjects: A total of 568 adult participants, 325 women and 243 men. Methods: By means of logistic regression models, the relation of fatty acids to (i) allergic sensitisation as defined by means of specific serum immunoglobulin E analysis (CAPSX1 class Z2), and (ii) self-reported allergic rhinitis was examined. Results: A high cell membrane level of eicosapentaenoic acid (EPA, 20:5 n-3) was inversely associated with allergic sensitisation, the adjusted odds ratio (OR) and 95% confidence interval (95% CI) were 0.52 (0.30-0.90) for the highest (vs lowest) quartile. A similar effect was observed for allergic rhinitis with an OR (95% CI) of 0.50 (0.24-1.03; P ¼ 0.027 for trend). A higher dietary intake of alpha-linolenic acid (ALA, 18:3 n-3) was associated with a decreased risk of allergic sensitisation and allergic rhinitis with ORs (95% CIs) of 0.51 (0.28-0.93) and 0.43 (0.20-0.93), respectively, in the highest quartiles. No other dietary or cell membrane unsaturated fatty acid was significantly associated with the outcome variables, nor was the n-6/n-3 ratio. The strongest effects were observed among subjects under the age of 40 y. Conclusions: In this cross-sectional study among adults, a high content of n-3 fatty acids in RBC membranes (EPA) or in the diet (ALA) is associated with a decreased risk of allergic sensitisation and allergic rhinitis. Sponsorship: The study was supported by funds of the Kurt-Eberhard-Bode-Stiftung and the Bavarian Ministry of Environment, Health and Consumer Protection.

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Increasing prevalence of specific IgE to aeroallergens in an adult population: Two cross-sectional surveys 8 years apart

Cited by 143 publications

References 19 publications

No further increase in asthma, hay fever and atopic sensitisation in adolescents living in Switzerland

No further increase in asthma, hay fever and atopic sensitisation in adolescents living in Switzerland

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Allergic sensitisation and allergic rhinitis are associated with n-3 polyunsaturated fatty acids in the diet and in red blood cell membranes

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