Increasing prevalence of coeliac disease over time

Lohi, Sini; Mustalahti, K.; Kaukinen, Katri; Laurila, Kaija; Collin, Pekka; Rissanen, Harri; Lohi, Olli; Bravi, E.; Gasparin, Maurizio; Reunanen, Antti; Mäki, Markku

doi:10.1111/j.1365-2036.2007.03502.x

Cited by 667 publications

(525 citation statements)

References 41 publications

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“…Originally a disease of childhood, CD is now more frequently first diagnosed in adults and has a prevalence of around 1% in Europe and the US (Bingley et al, 2004;Dube et al, 2005;Lohi et al, 2007;West, Logan,Smith, Hubbard & Card, 2003) . This change in presentation is partly explained by the increasing use of serological tests for active case-finding and for targeted screening in high risk groups (Collin, 2005;Hin et al, 1999;Jones, 2007;Karponay-Szabo et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Intentional and inadvertent non-adherence in adult coeliac disease. A cross-sectional survey

2013

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Publisher's copyright statement: NOTICE: this is the author's version of a work that was accepted for publication in Appetite. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be re ected in this document. Changes may have been made to this work since it was submitted for publication. A de nitive version was subsequently published in Appetite, 68, 2013Appetite, 68, , 10.1016Appetite, 68, /j.appet.2013 Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. ABSTRACTAdherence to a gluten-free diet is the mainstay of treatment for coeliac disease. Nonadherence is common as the diet is restrictive and can be difficult to follow. This study aimed to determine the rates of intentional and inadvertent non-adherence in adult coeliac disease and to examine the factors associated with both. A self-completion questionnaire was mailed to adult coeliac patients identified from the computer records of 31 family practices within the North East of England. We received 287 responses after one reminder. Intentional gluten consumption was reported by 115 (40%) of respondents. 155 (54%) had made at least one known mistaken lapse over the same period and 82 (29%) reported neither intentional nor mistaken gluten consumption.Using logistic regression analysis, low self-efficacy, perceptions of tolerance to gluten and intention were found to be independently predictive of intentional gluten consumption. A statistical model predicted 71.8% of cases reporting intentional lapses.Intentional non-adherence to the GFD was found to be common but not as frequent as inadvertent lapses. Distinguishing the factors influencing both intentional and inadvertent non-adherence is useful in understanding dietary self-management in coeliac disease.

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Section: Introductionmentioning

confidence: 99%

Intentional and inadvertent non-adherence in adult coeliac disease. A cross-sectional survey

2013

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“…24 However, it is not certain in either study how many were true cases because biopsies to confirm diagnosis were not performed.…”

Section: Figurementioning

confidence: 99%

The Rising Incidence of Celiac Disease in Scotland

et al. 2013

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BACKGROUND AND OBJECTIVES: Although the incidence of pediatric celiac disease (CD) is increasing globally, it is uncertain whether this is attributed to improved case ascertainment or signifies a true rise. We aimed to identify all incident cases of childhood CD in southeast Scotland over the period 1990 to 2009 to assess trends in total incidence and cases diagnosed as a result of (1) a classic presentation, (2) a nonclassic presentation, or (3) targeted screening. METHODS: Twenty-year retrospective cohort study of case notes, pathology databases, endoscopy, and patient records for all children (<16 years of age) diagnosed with CD on biopsy in southeast Scotland (at-risk population of 225 000–233 000). Data were age-gender standardized and Poisson regression models used to calculate changes in incidence over time. RESULTS: A total of 266 children were diagnosed from 1990 to 2009 with an increase in incidence from 1.8/100 000 (95% confidence interval [CI] 1.1–2.7) to 11.7/100 000 (95% CI 9.8–13.9) between the epochs 1990 to 1994 and 2005 to 2009, respectively (P < .0001). The incidence of nonclassic presentation (children with a monosymptomatic presentation and those with extraintestinal symptoms) and actively screened cases increased by 1566% (P < .05) and 1170% (P < .001) from 1990 to 1999 to 2000 to 2009, respectively. However, a rise in the incidence of Oslo classic cases from 1.51/100 000 (95% CI 0.91–2.38) in 1990 to 1994 to 5.22/100 000 (95% CI 3.98–6.75) in 2005 to 2009 (P < .01) remained evident. CONCLUSIONS: The incidence of pediatric CD increased 6.4-fold over the 20 years. This study demonstrates that this rise is significant for classic CD, indicating a true rise in the incidence of pediatric CD.

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“…HLA-DQ8 also confers a risk of type 1 diabetes [4] . Celiac disease affects at least 10% of patients with type 1 diabetes at some point in their lives [5] , with a prevalence that varies between 0.6%-16.4%, according to different studies [6][7][8] . The prevalence of celiac disease among children with type 1 diabetes is significantly higher than in non-diabetic children (in Western countries celiac disease affects around 1%-2% of the non-diabetic population).…”

Section: Introductionmentioning

confidence: 99%

Type 1 diabetes and celiac disease: The effects of gluten free diet on metabolic control

Scaramuzza

Mantegazza²,

Bosetti³

et al. 2013

WJD

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Type 1 diabetes mellitus is associated with celiac disease, with a prevalence that varies between 0.6% and 16.4%, according to different studies. After a diagnosis of celiac disease is confirmed by small bowel biopsy, patients are advised to commence a gluten-free diet (GFD). This dietary restriction may be particularly difficult for the child with diabetes, but in Europe (and in Italy) many food stores have targeted this section of the market with better labeling of products and more availability of specific GFD products. Treatment with a GFD in symptomatic patients has been shown to improve the symptoms, signs and complications of celiac disease. However, the effects of a GFD on diabetic control are less well established. Initial reports of improved hypoglycemic control were based on children who were diagnosed with celiac disease associated with malabsorption, but there have subsequently been reports of improvement in patients with type 1 diabetes with subclinical celiac disease. There are other studies reporting no effect, improved control and an improvement of hypoglycemic episodes. Moreover, in this review we wish to focus on low glycemic index foods, often suggested in people with type 1 diabetes, since they might reduce postprandial glycemic excursion and enhance longterm glycemic control. In contrast, GFD may be rich in high glycemic index foods that can increase the risk of obesity, insulin resistance and cardiovascular disease, worsening the metabolic control of the child with diabetes. Hence, it is important to evaluate the impact of a GFD on metabolic control, growth and nutritional status in children with type 1 diabetes.

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Increasing prevalence of coeliac disease over time

Abstract: SUMMARY BackgroundThe number of coeliac disease diagnoses has increased in the recent past and according to screening studies, the total prevalence of the disorder is around 1%.

Cited by 667 publications

References 41 publications

Intentional and inadvertent non-adherence in adult coeliac disease. A cross-sectional survey

Intentional and inadvertent non-adherence in adult coeliac disease. A cross-sectional survey

The Rising Incidence of Celiac Disease in Scotland

Type 1 diabetes and celiac disease: The effects of gluten free diet on metabolic control

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