Increasing predominance of G8P[8] species A rotaviruses in children admitted to hospital with acute gastroenteritis in Thailand, 2010-2013

Yodmeeklin, Arpaporn; Khamrin, Pattara; Malasao, Rungnapa; Ukarapol, Nuthapong; Ushijima, Hiroshi; Maneekarn, Niwat

doi:10.1007/s00705-018-3848-0

Cited by 25 publications

(70 citation statements)

References 67 publications

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“…The first DS-1-like G8P [8] strains were identified in children with severe diarrhea in Thailand in 2013 (3,6,7), with others subsequently detected in Vietnam and Hokkaido Prefecture, the main northern island of Japan, in 2014 (4,5). Furthermore, in 2017 we identified a DS-1-like G8P [8] strain (RVA/Human-wt/JPN/ SO1162/2017/G8P [8]) in Chiba Prefecture, Japan.…”

mentioning

confidence: 75%

Characterization of an Unusual DS-1-Like G8P[8] Rotavirus Strain from Japan in 2017: Evolution of Emerging DS-1-Like G8P[8] Strains through Reassortment

et al. 2019

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Rotavirus A (RVA), a member of the genus Rotavirus and family Reoviridae, comprises an 11-segment RNA genome encoding 6 structural proteins (VP1-VP4, VP6, and VP7) and 6 non-structural proteins (NSP1-NSP6). Majority of the human RVAs have genes with sequences similar to those of the prototype human strain Wa (genogroup 1) or DS-1 (genogroup 2) gene. Walike strains are characterized by the non-G/P genotype I1-R1-C1-M1-A1-N1-T1-E1-H1 and tend to possess G/P genotypes G1P[8], G3P[8], G4P[8], G9P[8], and G12P[8]. In contrast, DS-1-like strains are characterized by the non-G/P genotype I2-R2-C2-M2-A2-N2-T2-E2-H2 and tend to have the G/P genotype G2P[4] (1). The rapid emergence and spread of novel intergenogroup reassortant strains have recently been reported in several countries (2). Of these, DS-1-like G8P[8] strains with bovine-like G8 genotypes have recently emerged as major strains in Thailand, Vietnam, and Japan in Asia (3-7).

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confidence: 75%

Characterization of an Unusual DS-1-Like G8P[8] Rotavirus Strain from Japan in 2017: Evolution of Emerging DS-1-Like G8P[8] Strains through Reassortment

et al. 2019

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“…9 Uncommon genotypes found in this study-G1P7 [5], G5P [19], G9P [4], and G9P [6]-add to the existing list of uncommon genotypes reported to circulate in Thailand. 19,33,34 The presence of uncommon genotypes and the regular shifting of predominant genotypes may contribute to the likelihood of uncommon genotypes to become common global genotypes. 5,7 This will have an important implication for the development of an effective vaccine with genotype cross protection against rotavirus in the future, specifically in Thailand.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Genotypic Distribution of Rotavirus in Thailand: A Multicenter Study

Sakpaisal

Silapong

Yowang

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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Rotavirus has been one of the major etiological agents causing severe diarrhea in infants and young children worldwide. In Thailand, rotavirus contributes to one-third of reported pediatric diarrheal cases. We studied stool samples from 1,709 children with acute gastroenteritis and 1,761 children with no reported gastroenteritis whose age ranged from 3 months to 5 years from four different regions in Thailand between March 2008 and August 2010. The samples were tested for the presence of rotavirus by real-time reverse transcription-polymerase chain reaction (RT-PCR) amplification of vp6 gene and enzyme-linked immunosorbent assay. The positive samples were further characterized for their G and P genotypes (vp7 and vp4 genes) by conventional RT-PCR. From all four regions, 26.8% of cases and 1.6% of controls were positive for rotavirus, and G1P[8] was the most predominant genotype, followed by G2P[4], G3P[8], and G9P[8]. In addition, the uncommon genotypes including G1P[4], G1P[6], G2P[6], G2P[8], G4P[6], G9P[4], G9P[6], G12P[6], and G12P [8] were also detected at approximately 14% of all samples tested. Interestingly, G5P[19], a recombinant genotype between human and animal strains, and G1P7[5], a reassortant vaccine strain which is closely related to four humanbovine reassortant strains of RotaTeq ™ vaccine, were detected in control samples. Data reported in this study will provide additional information on molecular epidemiology of rotavirus infection in Thailand before the impending national implementation of rotavirus vaccination program.

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“…G1P [8] strains were G3P [8]. Uncommon genotypes found were G1P7 [5], G5P [19], G9P [4], and G9P [6], adding to the existing list of uncommon genotypes reported to circulate in Thailand [67][68][69][70][71][73][74][75][76].…”

Section: Rv Genotype Distributionmentioning

confidence: 99%

Rotavirus infection in children in Southeast Asia 2008–2018: disease burden, genotype distribution, seasonality, and vaccination

et al. 2020

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Background Rotaviruses (RVs) are recognized as a major cause of acute gastroenteritis (AGE) in infants and young children worldwide. Here we summarize the virology, disease burden, prevalence, distribution of genotypes and seasonality of RVs, and the current status of RV vaccination in Southeast Asia (Cambodia, Indonesia, Lao People’s Democratic Republic, Malaysia, Myanmar, Philippines, Singapore, Thailand, and Vietnam) from 2008 to 2018. Methods Rotavirus infection in Children in Southeast Asia countries was assessed using data from Pubmed and Google Scholars. Most countries in Southeast Asia have not yet introduced national RV vaccination programs. We exclude Brunei Darussalam, and Timor Leste because there were no eligible studies identified during that time. Results According to the 2008–2018 RV surveillance data for Southeast Asia, 40.78% of all diarrheal disease in children were caused by RV infection, which is still a major cause of morbidity and mortality in children under 5 years old in Southeast Asia. Mortality was inversely related to socioeconomic status. The most predominant genotype distribution of RV changed from G1P[8] and G2P[4] into the rare and unusual genotypes G3P[8], G8P[8], and G9P[8]. Although the predominat strain has changed, but the seasonality of RV infection remains unchanged. One of the best strategies for decreasing the global burden of the disease is the development and implementation of effective vaccines. Conclusions The most predominant genotype distribution of RV was changed time by time. Rotavirus vaccine is highly cost effective in Southeast Asian countries because the ratio between cost per disability-adjusted life years (DALY) averted and gross domestic product (GDP) per capita is less than one. These data are important for healthcare practitioners and officials to make appropriate policies and recommendations about RV vaccination.

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Increasing predominance of G8P[8] species A rotaviruses in children admitted to hospital with acute gastroenteritis in Thailand, 2010-2013

Cited by 25 publications

References 67 publications

Characterization of an Unusual DS-1-Like G8P[8] Rotavirus Strain from Japan in 2017: Evolution of Emerging DS-1-Like G8P[8] Strains through Reassortment

Characterization of an Unusual DS-1-Like G8P[8] Rotavirus Strain from Japan in 2017: Evolution of Emerging DS-1-Like G8P[8] Strains through Reassortment

Prevalence and Genotypic Distribution of Rotavirus in Thailand: A Multicenter Study

Rotavirus infection in children in Southeast Asia 2008–2018: disease burden, genotype distribution, seasonality, and vaccination

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