Increasing our understanding of pigmentary disorders

Grimes, Pearl E.; Nordlund, James J.; Pandya, Amit G.; Taylor, Susan C.; Rendon, Marta; Ortonne, Jean Paul

doi:10.1016/j.jaad.2005.12.042

Cited by 44 publications

(29 citation statements)

References 30 publications

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“…Em 2006, tal instrumento foi traduzido para o português e adaptado culturalmente, de acordo com as regras estabelecidas pela Organização Mundial da Saúde. [65][66][67]74 O tratamento do melasma é geralmente insatisfatório, pela grande recorrência das lesões e pela ausência de uma alternativa de clareamento definitivo. Estudos clínicos controlados indicam a fotoproteção e uso de clareadores como as medidas de primei-A B C FIGURA 7: Fotos clínicas de pacientes com melasma, demonstrando as principais topografias acometidas.…”

Section: Melasmaunclassified

Fisiopatologia do melasma

Miot¹,

Miot²,

Silva³

et al. 2009

An. Bras. Dermatol.

113

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Resumo: Melasma é uma dermatose comum que cursa com alteração da cor da pele normal, resultante da hiperatividade melanocítica focal epidérmica de clones de melanócitos hiperfuncionantes, com consequente hiperpigmentação melânica induzida, principalmente, pela radiação ultravioleta. Clinicamente, caracteriza-se por manchas acastanhadas, localizadas preferencialmente na face, embora possa acometer também região cervical, torácica anterior e membros superiores. Mulheres em período fértil e de fototipos intermediários representam as populações mais acometidas. Grande parte de sua fisiopatogenia permanece desconhecida, havendo relação com fatores genéticos, hormonais, uso de medicamentos, cosméticos, endocrinopatias e fotoexposição. Os autores discutem os principais elementos relacionados à pigmentação da pele e ao desenvolvimento do melasma. Palavras-chave: Melanose; Pigmentação da pele; Raios Ultravioleta; Transtornos da pigmentação Abstract: Melasma is a common dermatosis that involves changes in normal skin pigmentation, resulting from the hyperactivity of epidermal melanocytes. The consequent hyperpigmentation is mostly induced by ultraviolet radiation. Clinically, melasma is characterized by light to dark brown macules that usually occur on the face, although they can also affect the cervical and anterior thoracic regions and upper members. Fertile age women and those with intermediate skin phototypes are most likely to develop melasma. Most of its physiopathogenics is not yet fully understood, but there is a relation with genetic and hormonal factors, drugs and cosmetics use, endocrinopathies and sun exposure. The authors discuss the main aspects associated with skin pigmentation and the development of melasma.

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Section: Melasmaunclassified

Fisiopatologia do melasma

Miot¹,

Miot²,

Silva³

et al. 2009

An. Bras. Dermatol.

113

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“…The use of whitening agents can be driven by medicinal necessity in the case of persons suffering from dermatological conditions linked to an abnormal accumulation of melanin (e.g., melasma, senile lentigo, etc.) [3] or simply by culture-specific beauty preferences. Numerous chemical substances have already been proven as effective skin whiteners, and some even display beneficial side effects (antioxidants [4][5][6][7], antiproliferative activity [8,9], protection of macromolecules such as collagen against UV radiation [4], etc.…”

Section: Introductionmentioning

confidence: 99%

Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners

et al. 2016

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Abstract:With the public's growing interest in skin whitening, lightening ingredients only used under dermatological supervision until recently, are more and more frequently incorporated into cosmetic formulas. The active agents that lighten skin tone are either natural or synthetic substances, and may act at various levels of melanogenesis. They are used to treat various skin pigmentation disorders or simply to obtain a lighter skin tone as whiter skin may be synonymous of wealth, health, youth, and/or beauty in different cultures. However, recent studies demonstrated the adverse effects of some of these ingredients, leading to their interdiction or restricted use under the European Directive and several other international regulations. After an overview of skin whitening practices and the associated risks, this article provides insight into the mechanisms involved in melanin synthesis and the biological assays available to attest the lightening activity of individual ingredients. The legislation dealing with the use of skin lighteners is then discussed. As traditional depigmenting agents such as hydroquinone and corticosteroids are of safety concern, the potential of natural extracts has been investigated more and more; finally, a synthesis of three years of research in our laboratory for such plant extracts will be given.

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“…18 Upper and lower endoscopy should be performed every 2 years. 19 Removal is advised for symptomatic polyps or for those measuring Ͼ1.5 cm in size.…”

Section: Patient Managementmentioning

confidence: 99%

Cutaneous Manifestations of Internal Malignancy

Thiers¹,

Sahn²,

Callen³

2009

CA: A Cancer Journal for Clinicians

121

107

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The skin often mirrors changes in the organism it envelops. Many neoplastic diseases that affect internal organs display cutaneous manifestations, which may be the presenting signs and symptoms of the underlying malignancy. These may reflect direct involvement of the skin by the tumor (ie, tumor metastasis) or indirect involvement, in which changes in the skin occur in the absence of malignant cells. This review focuses on the latter conditions, which are often referred to as paraneoplastic dermatoses. Included in the discussion are the cutaneous manifestations of inherited syndromes that are associated with an increased risk of internal malignancy, cutaneous changes in patients with hormone-secreting tumors, and the wide spectrum of proliferative and inflammatory dermatoses that have been associated with internal cancer. CA Cancer J Clin 2009;59:73-98.

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Increasing our understanding of pigmentary disorders

Cited by 44 publications

References 30 publications

Fisiopatologia do melasma

Fisiopatologia do melasma

Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners

Cutaneous Manifestations of Internal Malignancy

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